Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Yolanda, Denny
Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Immunology & microbiology Neuroscience

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Utilization of Statins, an HMG-CoA reductase inhibitors, in Ambon District Hospital, Maluku: a retrospective study Simatupang, Abraham; Huningkor, Yusuf; Gasperz, Westi C; Nindatu, Maria; Noya, Farah; Sanaky, Marliyati; Hutagalung, Inggrid; Yolanda, Denny; Kailola, Natalie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.282 KB) | DOI: 10.19106/JMedSci005002201810

Abstract

Non-infectious diseases, including hypercholesterolemia, are now ranked top 10 inIndonesia. Statins are inhibitors of HMG-CoA reductase, an enzyme for biosynthesis ofcholesterol in the liver. Statins have been proven to reduce the risk of death due to CHDand mortality from various reasons. The objective of the study is to know the utilizationof statins in peripheral area of Indonesia. This retrospective study on utilization of statinsprescribed for hypercholesterolemia was taken from medical record year of 2014-2015of a District Hospital – Dr. Haulussy, Ambon, and Maluku. We collected demographicdata, pre- and treated concentrations of total cholesterol (TC), low-density lipoproteincholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG),types and dosages of statins or other lipid-lowering medications given. Student t-testusing was performed to check statistical differences for all cholesterol and TG differencesprior to therapy versus during treatment. Eighty three respondents consisted of 26 men(31.3%) and 57 women (68.7%) with mean age 60 ± 11 years old. The pre-treatment/post-treatment values (mg/dL) of TC: 245.22 ± 51.40/224.97 ± 98.79 (p=0.004);LDL-C: 166.07 ± 45.36/146.00 ± 41.07; HDL-C: 54.52 ± 37.95/43.00 ± 0.00; andTG: 177.36 ± 103.25/121.00 ± 52.87, respectively. Seventy-nine patients (95.2%)were treated with statins. The dosage given were 10 mg (n=19, 22.9%), 20 mg (n=63, 75.9%), and 40 mg (n=1, 1.2%). Twenty-eight patients (33.7%) had no posttreatmentdata of cholesterol, and 31 out of 55 patients (56%) were responders. Allcholesterol levels were decreased, but responder rate was only 56%. Therefore, dosageadjustment and prerequisite cholesterol level during and post-treatment measurementshould be made regularly.
Co-Authors Abraham Simatupang Gasperz, Westi C Huningkor, Yusuf Hutagalung, Inggrid Kailola, Natalie Nindatu, Maria Noya, Farah Sanaky, Marliyati