Objective: To determine the accuracy difference between CD4 percentage
and absolute CD4 in predicting the viral load of HIV-infected
pregnant women.
Methods: This study is a diagnostic study involving 22 HIV-infected
pregnant women who came for PMTCT at the Outpatient Clinic in
Sanglah Hospital, from September 2011 until August 2012, who
were randomly selected through consecutive sampling. Blood samples
were collected to analyze the viral load, CD4, and complete
blood count (CBC). Viral load examination was conducted using PCR
in the molecular biology laboratory in the Faculty of Medicine University
of Udayana. CD4 and CBC test was conducted in Sanglah Hospital
Laboratory. Analysis was done with 2x2 table using SPSS for
windows® version 17 to evaluate sensitivity, specificity and accuracy
rate of CD4 percentage and absolute CD4 in predicting the viral
load.
Results: Data analysis shows that CD4 percentage had 75.0% sensitivity,
88.9% specificity, and accuracy of 86.4% for predicting the viral
load in HIV-infected pregnant women. Meanwhile, absolute CD4
had 50.0% sensitivity, 77.8% specificity, and 72.7% accuracy. Chisquare
test shows that there was no significant difference in the accuracy
of CD4 percentage and absolute CD4 (p=0.457).
Conclusion: CD4 percentage and absolute CD4 had high accuracy in
predicting the viral load in HIV-infected pregnant women (86.4%
and 72.7%). There was no significant difference of accuracy between
the CD4 percentage and absolute CD4.
[Indones J Obstet Gynecol 2015; 3-4: 230-233]
Keywords: CD4, HIV-infected pregnant women, viral load