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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Liga, Elisabeth G.K.
Indonesian Socety of Obstetrics and Gynecology
Health Professions Medicine & Pharmacology Public Health

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The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients Liga, Elisabeth G.K.; Abdullah, Nusratuddin; Tiro, Eddy; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.105 KB) | DOI: 10.32771/inajog.v6i1.761

Abstract

Objective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.[Indones J Obstet Gynecol 2018; 6-1: 64-67]Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserveObjective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserve
The Effect of Cyclophosphamide Chemotherapy on Ovarian AntiMüllerian Hormone Levels in Breast Cancer Patients Liga, Elisabeth G.K.; Abdullah, Nusratuddin; Tiro, Eddy; T. Chalid, St. Maisuri
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 1. January 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.105 KB) | DOI: 10.32771/inajog.v6i1.761

Abstract

Objective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.[Indones J Obstet Gynecol 2018; 6-1: 64-67]Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserveObjective: To evaluate cyclophosphamide effects on Anti-Müllerian hormone (AMH) levels in breast cancer patientstreated with cyclophosphamide chemotherapy.Methods: This cohort prospective study was conducted inDr. Wahidin Sudirohusodo Hospital in the Department of Obstetricsand Gynecology in collaboration with Department of Surgery,Faculty of Medicice, Universitas Hasanuddin between September2015 and June 2016. Serum levels of AMH from forty breast cancerpatients received three series of cyclophosphamide chemotherapydetermined by Enzyme Linked Immuno Sorbent Assay (ELISA).Results: Serum AMH levels decreased significant in the first series(from 2.092.04 g/ml to o.651.06 g/ml; p<0.05) through thethird series (from 1.531.34 g/ml to 0.50.65 g/ml; p<0.05) ofcyclophosphamide chemotherapy.Conclusion: AMH levels decreased significant after cyclophosphamideindicated that cyclosphosphamide decrease ovarianreserve.Keywords: anti-müllerian hormone, breast cancer, cyclophosphamide,ovarian reserve
Co-Authors Eddy Tiro Nusratuddin Abdullah T. Chalid, St. Maisuri