The main symptom of diabetes mellitus is an increase of blood glucose concentration, therefore it can be decreased using natural substances. The research aimed to the combination of Caesalpania sappan L wood and Aloe vera leaves liquids can decrease the concentration of blood glucose in Mus musculus. This research used pre-post-test design with RAL. The subjects were 24 Mus musculus of BALB/cAnN strain. The chemical subtance used to increase the concentration of blood glucose was 1 cc/kgBB of dextrose monohydrate 5 %. The animals were devided into 6 groups that are threated by giving: 1) aquades (KK); 2) Caesalpania sappan L wood liquid 100% (KP1); 3) Aloe vera leaves liquid 100% (KP2); 4) combination of Caesalpania sappan L wood and Aloe vera leaves liquid 20% (KP3); 5) combination of Caesalpania sappan L wood and Aloe vera leaves liquid 40% (KP4); 6) combination of Caesalpania sappan L wood and Aloe vera leaves liquid 60% (KP5). The concentration of blood glucose was measured using glico test. The data gained were analyzed using T test and One-Way ANOVA at 5% of level test. After giving dextrose monohydrate the glucose concentration of all samples was 160,75 mg/dl.The results of this research shows that the decrease of glucose concentration of KP1 was 123,75 mg/dl; KP2 was 120,25 mg/dl; KP3 was 118,5 mg/dl; KP4 was 115,75 mg/dl; and KP5 was 109,75 mg/dl. The analysis result revealed that combination of Caesalpania sappan L wood and Aloe vera leaves liquids can decrease of the concentration of blood glucose in Mus musculus (Fcount (3,499) > Ftable (1,83) with sig value < 0,05) and (tcount (10,939) > ttable (1,714)) with sig value < 0,05) . It can be concluded that the combination of Caesalpania sappan L wood and Aloe vera leaves liquids can decrease the concentration of blood glucose in Mus musculus.
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