As-syifaa Jurnal Farmasi
Vol 10, No 2 (2018): AS-SYIFAA Jurnal Farmasi

PENENTUAN DOSIS MINIMUM EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) TERHADAP PENURUNAN KADAR TRIGLISERIDA PADA TIKUS OBESITAS

Irma Santi (Fakultas Farmasi Universitas Muslim Indonesia, Makassar)
Rizqi Nur Azizah (Fakultas Farmasi Universitas Muslim Indonesia, Makassar)
Mu’ammar Mu’ammar (Fakultas Farmasi Universitas Muslim Indonesia, Makassar)



Article Info

Publish Date
01 Dec 2018

Abstract

Common purslane (Portulace Oleracea L.) has a compound of omega-3, flavonoid and ascorbic acid with the activity in decreasing triglyceride levels. This study aimed to determine the minimum dose of ethanol extract of common purslane against the decrease of triglyceride levels of obese mice. It used 18 rats fed high-calorie diet (HCD) for 30 days. The obese rats were devided into 6 groups consisting of group I of negative controls (Na.CMC ), group II of positive control (gemfibrozil®), group III,IV,V,VI provided the ethanol extract of common purslane (EECP) with 25 mg/kgBW, 50 mg/kgBW, 75 mg/kgBW, 100 mg/kgBW. Afterwards, 14 days of therapy were given and still fed a high-calorie (HCD). The measurement of triglyceride levels is performed before induction (early). After induction , and after therapy. The data of the study were analized by percentage decrease of each test group. The result show that the EECP groups of 75 mg/kgBW was the minimum dose in lowering triglyceride levels with a decrease of 16,49 %. 

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Journal Info

Abbrev

as-syifaa

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

As-Syifaa Jurnal Farmasi receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmacology and Toxicology, Pharmaceutical Microbiology and Biotechnology, Herbal Medicines, Pharmaceutics, ...