Jurnal Ilmiah Farmasi
Vol. 5 No. 1 (2008)

RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE

Muhtadi Muhtadi (Unknown)
Euis H. Hakim (Unknown)
Yana M. Syah (Unknown)
Lia D. Juliawaty (Unknown)
Jalifah Latip (Unknown)



Article Info

Publish Date
25 May 2009

Abstract

ABSTRACTTwo resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetoneextract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the knownresveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based onspectroscopic evidence, UV, IR,1H-NMR,13C-NMR and determined by comparison with thestandard compounds. The cytotoxic activities of these compounds were evaluated against murineleukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shoreaand Vatica will also be briefly discussed.Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratroltetramer

Copyrights © 2008






Journal Info

Abbrev

JIF

Publisher

Subject

Medicine & Pharmacology

Description

JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta ...