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All Journal Jurnal Ilmiah Farmasi Jurnal Matematika & Sains
Jalifah Latip
School of Chemistry and Food Technology, Faculty of Science and Technology, UKM
Mathematics Medicine & Pharmacology

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Tiga Senyawa Oligostilbenoid dari Kulit Batang Dipterocarpus retusus Blume (Dipterocarpaceae) Muhtadi Muhtadi; Euis Holisotan Hakim; Yana Maolana Syah; Lia Dewi Juliawaty; Sjamsul Arifin Achmad; Ikram M. Said; Jalifah Latip
Jurnal Matematika & Sains Vol 10, No 4 (2005)
Publisher : Institut Teknologi Bandung

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Three oligostilbenoids, (-)-ε-viniferin, (-)-α-viniferin and (-)-vaticanol A, together with two derivative coumarin compounds, scopoletin and (-)-bergenin, were isolated from acetone extracts of the tree bark of Dipterocarpus retusus Blume. The chemical structure of the isolates were established based on spectroscopic data, UV, IR, 1H-NMR, 13C-NMR, and by comparison with the related compounds. (-)-ε-Viniferin, (-)-α-viniferin and (-)-vaticanol A showed cytotoxic activity against murine leukaemia P-388 cells with their IC50 values were 7,8; 17,5 and 27,0 µg/mL, respectively.
Senyawa-senyawa Oligomer Resveratrol dari Kulit Batang Shorea brunnescens (Dipterocarpaceae) Haryoto Haryoto; Yana Maolana Syah; Lia Dewi Juliawaty; Sjamsul Arifin Achmad; Jalifah Latip; Euis Holisotan Hakim
Jurnal Matematika & Sains Vol 11, No 3 (2006)
Publisher : Institut Teknologi Bandung

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Six resveratrol oligomers, namely (-)- ε-viniferin (1), (-)-laevifonol (2), (-)-vaticanol B (3), (-)-hemsleyanol D (4), (+)-isohopeaphenol (5), and (-)-hopeaphenol (6) have been isolated from the acetone extract of the stem bark of Shorea brunnescens. The structure determination of these compounds were based on spectroscopic data (UV, IR, 1H NMR), and compared with literature data. The cytotoxicity of isolated compounds against murine leukemia P-388 cells showed the IC50 values as 18.1, 23.2, 41.9, 12.3, 39.7, and 5.5 µM, respectively.
Dua Flavonoid Tergeranilasi dari Daun Sukun (Artocarpus altilis) Yana Maolana Syah; Sjamsul Arifin Achmad; Eri Bakhtiar; Euis Holisotan Hakim; Lia Dewi Juliawaty; Jalifah Latip
Jurnal Matematika & Sains Vol 11, No 3 (2006)
Publisher : Institut Teknologi Bandung

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Two geranylated flavonoid derivatives, namely 2-geranyl-2,4,3,4-tetrahydroxydihydrochalcone (1) and 8-geranyl-4,5,7-trihydroxy-flavanone (2), had been isolated from methanol extract of the leaves of sukun (Artocarpus altilis). The structures of the two compounds were determined based on UV, IR, 1H NMR and 13C NMR spectra, and by comparing with the previously reported data. The presence of these two compounds in A. altilis indicated that the leaves of Artocarpus plants tend to produce more simple flavonoids.  
RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE Muhtadi Muhtadi; Euis H. Hakim; Yana M. Syah; Lia D. Juliawaty; Jalifah Latip
Jurnal Ilmiah Farmasi Vol. 5 No. 1 (2008)
Publisher : Universitas Islam Indonesia

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ABSTRACTTwo resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetoneextract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the knownresveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based onspectroscopic evidence, UV, IR,1H-NMR,13C-NMR and determined by comparison with thestandard compounds. The cytotoxic activities of these compounds were evaluated against murineleukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shoreaand Vatica will also be briefly discussed.Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratroltetramer
Co-Authors Eri Bakhtiar Euis H. Hakim Euis Holisotan Hakim Haryoto Haryoto Ikram M. Said Lia D. Juliawaty Lia Dewi Juliawaty Muhtadi Muhtadi Sjamsul Arifin Achmad Yana M. Syah Yana Maolana Syah