Jurnal Kimia Mulawarman
Vol 16 No 2 (2019)

STUDI POTENSI SENYAWA DERIVATIF FLAVONOID DARI TANAMAN GENUS MACARANGA TERHADAP PROTEIN E6 HPV DENGAN METODE DOCKING MOLECULAR

Veliyana Londong Allo (Jurusan Kimia FMIPA Universitas Mulawarman)
Djihan Ryn Pratiwi (Jurusan Kimia FMIPA Universitas Mulawarman)



Article Info

Publish Date
31 May 2019

Abstract

Interaction study of active compounds of a medicinal plant with cervical cancer cells using the Docking Molecular (In Silico) method. In this research design the active compound sophoraflavanone B, 5,7,3 ', 4'-tetrahidroxy-3,6-diprenylflavone, apigenin and quercetin are first calculated using a quantum approach based on SCF method set 3-21G to obtain a stable compound form and has the lowest energy. Stable compounds interact with cervical cancer cells obtained from protein bank data (GDP) that have been prepared previously to obtain an inhibitory energy value, the number of hydrogen bonds and other factors that influence a Docking Molecular calculation. The interaction of compounds 5,7,3 ', 4'-tetrahydroxy-3,6-diprenylflavone against E6-HPV of 4 hydrogen bonds with a distance of 2.7-3.23 Å.

Copyrights © 2019






Journal Info

Abbrev

JKM

Publisher

Subject

Chemistry

Description

Journal of Kimia Mulawarman is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry and applied ...