Folia Medica Indonesiana
Vol. 55 No. 2 (2019): June

The Effect of Methylmercury Exposure on Astrocyte of Cerebellar Cortex of White Rats (Rattus novergicus)

Paulus Sugianto (Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya)
Sabrina Melisa Pardede (Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya)
Ngakan Made Rai Widjaja (Department of Basic Veterinary Medicine, Universitas Airlangga, Surabaya)
Widjiati Widjiati (Department of Anatomy Veterinary, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya)



Article Info

Publish Date
30 Jun 2019

Abstract

The aim of this research was to investigate the effect of different dose methylmercury (II) chloride on astrocyte in cerebellar cortex of white rat (Rattus norvegicus) exposed. This study used randomized control design using 15 adult female Wistar rats weight 180-200 g of body weight. Before treatment the white rats was adapted in a week, then randomly divided into 3 groups each consist of 5 rats. P0 as control were given 0.5 ml aquades, P1 and P2 were given 0.1 and 0.2 mg/kg/day respectively. All groups were given treatment per oral in 30 days with sonde. The data was analyzed by ANOVA, Duncan's multiple range (Duncan's Multiple Range Test). White rats exposed by methylmercury (II) chloride, had a significant differences in the percentage of necrotic astrocyte (p<0.05). Methylmercury chloride exposure increases the number of necrotic astrocytes on white rat.

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Journal Info

Abbrev

FMI

Publisher

Subject

Other

Description

Folia Medica Indonesiana publishes articles in the field of medical science in particular and health sciences in general, as well as a variety of other fields related to those two disciplines. Most of the articles are research article, and others are articles on case reports and literature review. ...