Jurnal Kimia dan Kemasan
Vol. 43 No. 2 Oktober 2021

Synthesis of 9-(4-Methoxyphenyl)-3,3,6,6-tetra-3,4,5,6,7,9- hexahydro-2H-xantene-1 using Lime and Lemon Juice as the Environmentally Friendly Catalyst and Its Antioxidant Activity

Rini Retnosari (Jurusan Kimia Universitas Negeri Malang)
Nurul Ultiyati (Jurusan Kimia Universitas Negeri Malang)
Aman Santoso (Jurusan Kimia Universitas Negeri Malang)
Siti Marfu'ah (Jurusan Kimia Universitas Negeri Malang)
Ihsan Budi Rachman (Regional Environment System Department, Graduate School of Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku Saitama 337-8570, Japan)

Article Info

Publish Date
08 Sep 2021

Abstract

The 9-(4-Methoxyphenyl)-3,3,6,6-tetra-3,4,5,6,7,9-hexahydro-2H-xantene-1 compound, which is addressed as compound 1 in this study, is the derivatives of 1,8-dioxo- octahydroxantene. This compound has a carbonyl group and double bond on beta carbon toward the carbonyl group and benzene ring. The presence of this chromophore helps the compound creates intermediate stabilized by resonance from its interaction with free radicals and has the potential to be an antioxidant. Compound 1 was synthesized from p- methoxybenzaldehyde and dimedone through Knoevenagel condensation reaction using an acid as catalyst. The lime and lemon juice was selected as a catalyst to support green chemistry principle. The obtained product includes white powder with a melting point of 222-224oC. The IR analysis results, GC-MS, and 1H-NMR data show that the compound structure of Compound 1. Meanwhile, the antioxidant activity test using the DPPH method reveal that Compound 1 has the antioxidant activity with IC50 of 22.74 ppm.

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Journal Info
Jurnal Kimia dan Kemasan
Website

Abbrev

jkk

Publisher

Balai Besar Kimia dan Kemasan, kementerian Perindustrian

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

Description

Jurnal Kimia dan Kemasan (JKK) publishes original research article related to Applied chemistry including natural product (essential oils, palm oil derivative, natural dye), biopolymer, chemical synthesis, and problems of chemical processes and apparatus; and also packaging material and ...