Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Vol. 7 No. 2 (2021): (October 2021)

The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin

Joni Tandi (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Indonesia)
Franciska Diana Pratiwi (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Indonesia)
surisna surisna (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Indonesia)
Niluh Puspita Dewi (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Indonesia)
Magfirah Magfirah (Department of Pharmacy, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Indonesia)

Article Info

Publish Date
10 Oct 2021

Abstract

This study aims to determine the effect of guava (Psidiium guajava L) leaf extract on hypercholesterolemia-diabetic white rats male and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III as positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves influenced reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effective reducing the cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.

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Journal Info
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Website

Abbrev

Galenika

Publisher

Universitas Tadulako

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Description

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is ...