Jurnal Matematika & Sains
Vol 11, No 3 (2006)

Senyawa-senyawa Oligomer Resveratrol dari Kulit Batang Shorea brunnescens (Dipterocarpaceae)

Haryoto Haryoto ( Fakultas Farmasi, Universitas Muhammadiyah Surakarta, Surakarta)
Yana Maolana Syah ( Kelompok Keahlian Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam)
Lia Dewi Juliawaty ( Kelompok Keahlian Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam)
Sjamsul Arifin Achmad ( Kelompok Keahlian Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam)
Jalifah Latip ( School of Chemical Science & Food Technology, Faculty of Science and Technology, UKM)
Euis Holisotan Hakim ( Kelompok Keahlian Kimia Organik, Fakultas Matematika dan Ilmu Pengetahuan Alam)



Article Info

Publish Date
07 Oct 2009

Abstract

Six resveratrol oligomers, namely (-)- ε-viniferin (1), (-)-laevifonol (2), (-)-vaticanol B (3), (-)-hemsleyanol D (4), (+)-isohopeaphenol (5), and (-)-hopeaphenol (6) have been isolated from the acetone extract of the stem bark of Shorea brunnescens. The structure determination of these compounds were based on spectroscopic data (UV, IR, 1H NMR), and compared with literature data. The cytotoxicity of isolated compounds against murine leukemia P-388 cells showed the IC50 values as 18.1, 23.2, 41.9, 12.3, 39.7, and 5.5 µM, respectively.

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