Ahmar Metastasis Health Journal (AMHJ)
Vol. 2 No. 1 (2022): Ahmar Metastasis Health Journal

Correlation of CRP Levels with Severity of Disease in Hospitalized Patients with Confirmed COVID-19: Korelasi Kadar CRP dengan Derajat Keparahan Penyakit pada Pasien Rawat Inap Terkonfirmasi COVID-19

Anisah Wulansari (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Poltekkes Kemenkes Jakarta III, Indonesia)
Rizana Fajrunni'mah (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Poltekkes Kemenkes Jakarta III, Indonesia)
Warida Warida (Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Poltekkes Kemenkes Jakarta III, Indonesia)



Article Info

Publish Date
29 Jun 2022

Abstract

ABSTRACT Introduction: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2. C-Reactive Protein (CRP) has been found to be an important marker that is significantly altered in severe COVID-19 patients. This study aims to determine the correlation of CRP levels with the agglutination method with the severity of the disease in hospitalized patients who are confirmed positive for COVID-19. This research is an analytic observational with a cross sectional design. The sample is in the form of medical record data of 80 inpatients who are confirmed positive for COVID-19 at Pasar Rebo Hospital for the period August 2020 to January 2021. The data collection process uses a purposive sampling technique. CRP levels (mg/L) were divided into 5 groups, namely <6, 6, 12, 24 and 48. Meanwhile, the severity of the disease was divided into 2 groups, namely mild-moderate and severe-critical. Chi Square statistical test was used to assess the correlation of CRP levels with the severity of the disease. Subjects consisted of 80 confirmed COVID-19 patients with 52.5% male gender more than female (47.5%). Age group 60 years 38.8%, the most compared to other age groups. The severe-critical group 60% more than the mild-moderate (40%). CRP levels <6 mg/L in 17.5% patients, CRP levels 6 mg/L in 3.8% patients, CRP levels 12 mg/L in 27.5% patients, CRP 24 mg/L in 31.3% patients and CRP levels 48 mg/L in 20% patients. The results of the Chi Square test showed a significant correlation between CRP levels and the severity of disease in inpatients confirmed positive for COVID-19 at Pasar Rebo Hospital with a p value of 0.000 at a 95% confidence level. CRP examination can be used as a marker to see the severity of disease in hospitalized patients who are confirmed positive for COVID-19. ABSTRAK Pendahuluan: Coronavirus Disease 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh SARS-CoV-2. C-Reactive Protein (CRP) telah ditemukan sebagai penanda penting yang berubah secara signifikan pada pasien COVID-19 yang parah. Penelitian ini bertujuan untuk mengetahui korelasi kadar CRP metode aglutinasi dengan derajat keparahan penyakit pada  pasien  rawat inap terkonfirmasi positif COVID-19. Penelitian ini adalah observasional analitik dengan desain cross sectional. Sampel berupa data rekam medis 80 pasien rawat inap terkonfirmasi positif COVID-19 di RSUD Pasar Rebo periode Agustus 2020 hingga Januari 2021. Proses pengambilan data dengan teknik purposive sampling. Kadar CRP (mg/L) dibagi dalam 5 kelompok yaitu <6, 6, 12, 24 dan 48. Sementara derajat keparahan penyakit dibagi dalam 2 kelompok yaitu ringan-sedang dan berat-kritis. Uji statistik Chi Square digunakan untuk menilai korelasi kadar CRP dengan derajat keparahan penyakit. Subjek terdiri dari 80 pasien terkonfirmasi COVID-19 dengan jenis kelamin laki-laki 52,5% lebih banyak dibandingkan perempuan 47,5%. Kelompok usia ≥ 60 tahun 38,8% paling banyak dibandingkan kelompok usia yang lain. Kelompok berat-kritis 60%, lebih banyak dibandingkan ringan-sedang 40%. Kadar CRP <6 mg/L sebanyak 17,5% pasien, kadar CRP 6 mg/L sebanyak 3,8% pasien, kadar CRP 12 mg/L sebanyak 27,5% pasien, kadar CRP 24 mg/L sebanyak 31,3% pasien dan kadar CRP 48 mg/L sebanyak 20% pasien. Hasil uji Chi Square didapatkan korelasi yang signifikan antara kadar CRP dengan derajat keparahan penyakit pada pasien rawat inap terkonfirmasi positif COVID-19 di RSUD Pasar Rebo dengan nilai p 0,000 pada tingkat kepercayaan 95%. Pemeriksaan CRP dapat digunakan sebagai salah satu penanda untuk melihat derajat keparahan penyakit pada pasien rawat inap terkonfirmasi positif COVID-19.

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Journal Info

Abbrev

AMHJ

Publisher

Subject

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Description

Ahmar Metastasis Health Journal (AMHJ), with registered number ISSN 2797-6483 (Print), 2797-4952 (Online) managed by the AHMAR Foundation, published by Yayasan Ahmad Mansyur Nasirah, which is a scientific forum for publishing articles on research activities in health (midwifery, pharmacy, nursing, ...