Media Farmasi Indonesia
Vol. 8 No. 2 (2013): Media Farmasi Indonesia

MOLECULAR DOCKING, SINTESIS DAN UJI AKTIVITAS SITOTOKSIK SENYAWA 1-(3-KLOROBENZOIL)-1,3-DIMETILUREA

Dian Agung Pangaribowo (Unknown)

Article Info

Publish Date
01 Oct 2013

Abstract

A novel 1-(3-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to the position of this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(3-chlorobenzoyl)-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 3-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography and melting point measurement. Structure identification was performed by UV and FTIR spectrophotometer, NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control. This compound with potent cytotoxic activity might be a potential anticancer agent.

Copyrights © 2013




Citation Download
RIS
EndNote, Reference Manager, ProCite
BibTex
Latex, Jabref
Full PDF
285.155 KB
Original Source
Download Original
Google Scholar
Check in Google Scholar
Journal Info
Media Farmasi Indonesia
Website

Abbrev

MFI

Publisher

Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other

Description

Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, ...