Indonesian Journal of Chemical Science and Technology
Vol 5, No 2 (2022): JULI 2022

Cytotoxicity Test of Cocoa Leaf Ethanol Extract (Theobroma Cacao L.) With Brine Shrimp Lethality Test (BSLT) Method

Zulmai Rani (Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah)
Ridwanto Ridwanto (Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah)
Dikki Miswanda (Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah)
Rafita Yuniarti (Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah)
Ani Sutiani (Department of Chemistry, Universitas Negeri Medan)
Ricky Andi Syahputra (Department of Chemistry, Universitas Negeri Medan,)
Reza Irma (Department of Pharmacy, Universitas Muslim Nusantara Al Washliyah)

Article Info

Publish Date
02 Aug 2022

Abstract

Cancer is a disease characterized by uncontrolled cell division and the ability of these cells to invade other biological tissues, either by direct growth in adjacent tissues or by migration of cells to distant sites. The purpose of this study was to determine the class of secondary metabolites contained in the ethanol extract of cocoa leaves and their cytotoxicity by looking at the LC50 value using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of ethanol extract and the BSLT method by looking at the number of deaths of Artemia salina leach larvae (LC50). The results of phytochemical screening tests showed that the cocoa leaves contained flavonoids, alkaloids, tannins, saponins, steroids, and glycosides. The cytotoxicity test with probit analysis showed an LC50 value of 269,15 µg/mL, so it was concluded that the ethanol extract of cocoa leaves was toxic and had potential as an anticancer.

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Journal Info
Indonesian Journal of Chemical Science and Technology
Website

Abbrev

aromatika

Publisher

Universitas Negeri Medan

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

Description

Jurnal ini mempublikasikan artikel di bidang Kimia yang meliputi penelitian dasar dan terapan. Bentuk Publikasi di Indonesian Journal of Chemical Science and Technology : * Artikel * Review (berdasarkan permintaan Dewan Redaksi) * Communication (berdasarkan permintaan Dewan ...