Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Vol. 7 No. 3 (2017)

A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index

Edi Hartoyo (Department of Pediatric, Ulin General Hospital/ Faculty of Medicine, Lambung Mangkurat University)
Iskandar Thalib (Research and Development Unit, Mutiara Bunda Mother and Child Hospital)
Cynthia Maharani Puspita Sari (Research and Development Unit, Mutiara Bunda Mother and Child Hospital)
Windy Yuliana Budianto (Department of Pediatric Nursery, Faculty of Medicine, Lambung Mangkurat University)
Eko Suhartono (Department of Medical Chemistry/Biochemistry, Faculty of Medicine, Lambung Mangkurat University)

Article Info

Publish Date
11 Sep 2017

Abstract

The objectives of this study were to determine the involvement of Oxidative Stress (OS) in the pathogenesis of dengue hemorrhagic fever (DHF) through the analysis of oxidative stress Index (OSI). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity, and OSI were measured in 61 child dengue patients and (aged 6 months–18 years) with three different stages of DHF, i.e stage I, II, and III. The results show that the levels of MDA, SOD and CAT activity, and OSI significantly different between the group. The all parameters that investigated in this present study seems higher MDA level and OSI in the higher grade of DHF, except for SOD and CAT activity. From this result, it can be concluded that oxidative stress pathways might be involved in the pathomechanism of DHF and OSI might be used as a biomarker for OS and the severity in DHF patients.

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Journal Info
Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Website

Abbrev

jtrolis

Publisher

Universitas Brawijaya

Subject

Agriculture, Biological Sciences & Forestry Environmental Science

Description

The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel ...