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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran The Indonesian Biomedical Journal JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) Smart Society Empowerment Journal
Windy Yuliana Budianto, Windy Yuliana
Department Of Pediatric Nursing, Faculty Of Medicine, Universitas Lambung Mangkurat, Jl. Ahmad Yani Km.36, Banjarbaru 70712
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Thalib, Iskandar; Budianto, Windy Yuliana; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
HUBUNGAN KADAR ENZIM ASETILKOLINESTERASE TERHADAP KADAR GLUKOSA PETANI YANG TERPAJAN PESTISIDA Suhartono, Eko; Edyson, Edyson; Budianto, Windy Yuliana; Sekartaji, Hapsari Lintang; Fahira, Nurul Savira; Cahyadi, Herry
Jurnal Publikasi Kesehatan Masyarakat Indonesia Vol 5, No 2 (2018): Jurnal Publikasi Kesehatan Masyarakat Indonesia
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpkmi.v5i2.5482

Abstract

AbstrakPestisida merupakan bahan kimia yang digunakan untuk mengendalikan serangga, jamur, gulma dan lain-lain. Penggunaan pestisida yang tak terkendali menyebabkan keracunan dan berdampak pada ganguan metabolisme. Untuk membuktikan hal tersebut telah diteliti hubungan antara kadar enzim asetilkolinesterase dengan kadar glukosa darah petani yang terpajan pestisida. Rancangan penelitian ini bersifat analitik, dengan pendekatan cross sectional. Subjek penelitian adalah seluruh anggota kelompok tani Kurnia Makmur di Kecamatan Landasan Ulin Utara Banjarbaru dengan menggunakan jumlah sampel minimal sebesar 60 orang. Pemeriksaan sampel kadar enzim asetilkolinesterase dalam darah dan glukosa dalam darah dilakukan dengan bekerjasama dengan Labkesda Kabupaten Banjar dengan No. 001/LKA/C/VII/2016 s/d 60/LKA/C/VII/2016. Data dikumpulkan dari Dinas Kesehatan Banjarbaru tahun 2016. Analisis bivariat digunakan untuk menjelaskan hubungan dua variabel yaitu antara kadar kolinesterase dengan kadar glukosa darah dengan menggunakan uji Spearman dengan derajat kepercayaan 95%. Hasil penelitian didapatkan rerata kadar asetilkolinesterase pada petani berjenis kelamin laki-laki dan perempuan melebihi batas normal (L= 4,6-11,5 U/L; P=3,9-10,8 U/L). Hal ini menandakan bahwa sebanyak 63,34% petani mengalami keracunan pestisida. Sementara itu, rerata kadar glukosa darah petani masih tergolong normal (Gula darah sewaktu „T 125 mg/dL) meskipun pada petani berjenis kelamin wanita ditemukan sebanyak 5% mengalami hiperglikemia. Hasil uji Spearman didapat r =0,049 (p=0,768; p>0,05) yang berarti tidak ada hubungan yang bermakna antara kadar asetilkolinesterase dengan kadar glukosa darah petani yang terpajan pestisida.Kata-kata kunci: Pestisida, kolinesterase, glukosa, diabetesAbstractPesticides are chemicals used to control insects, fungi, weeds and others. Uncontrolled use of pesticides causes poisoning and affects metabolic disorders. To prove the above has been investigated the relationship between the levels of enzyme acetylcholineserase with blood glucose levels of farmers exposed to pesticides. The design of this study is analytic, with cross sectional approach. Research subjects were all members of Kurnia Makmur farmer group in Kecamatan Landasan Ulin Utara Banjarbaru by using minimum sample amount of 60 people. Examination of samples of cholinesterase enzyme levels in blood and glucose in blood was done in collaboration with Labkesda Kabupaten Banjar with no. 001 / LKA / C / VII / 2016 s / d 60 / LKA / C / VII / 2016. Data was collected from Banjarbaru Health Office in 2016. Bivariate analysis was used to explain the relationship between two variables, ie, between cholinesterase and blood glucose level using Spearman test with 95% confidence degree. The result showed that the level of acetylcholinesterase in male and female farmers exceeded the normal limit (L = 4.6-11.5 U / L; P = 3.9-10.8 U / L). This indicates that as many as 63.34% of farmers are poisoned by pesticides. Meanwhile, the average blood glucose level of farmers is still normal (blood sugar at „T 125 mg / dL) although the female-female farmers found as many as 5% had hyperglycemia. Spearman test result obtained r = 0.049 (p = 0.768; p> 0.05) meaning there is no significant relation between level of acetylcholinesterase with blood glucose level of farmer exposed by pesticide.Keyword: pesticide, acetylcholinesterase, glucose, diabettes
Potensi ADP dan Katalase dalam Ekstrak Air Lidah Buaya (Aloe vera) sebagai Antiinflamasi pada Model Tikus Luka Terkontaminasi Biworo, Agung; Budianto, Windy Yuliana; Agustina, Rismia; Suhartono, Eko
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i1.1054

Abstract

Lidah buaya (Aloe vera) mengandung enzim antioksidan yang dapat menghambat kerja dari mediator inflamasi dan penghilang rasa sakit. Pada penelitian ini akan diukur aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase ekstrak air Aloe vera serta potensinya sebagai antiinflamasi pada tikus yang mengalami luka terkontaminasi. Penelitian ini menggunakan rancangan post test only control group dengan simple random sampling pada 36 ekor tikus yang terbagi atas 2 kelompok, yaitu kelompok kontrol (P0)  dan perlakuan (P1) merupakan kelompok tikus dengan luka terkontaminasi yang diberikan balutan dengan menggunakan ekstrak air lidah buaya 0,2 mg/g BB. Hasil penelitian menunjukkan bahwa aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase masing-masing 37,8 menit-1 dan 3,145 menit-1 dan rata-rata penurunan intensitas warna kemerahan dari eritema pada kelompok yang diberi ekstrak air lidah buaya (Aloe vera) lebih cepat daripada kelompok kontrol. Diismpulkan bahwa ekstrak air lidah buaya berpotensi sebagai antiinflamasi pada model tikus luka terkontaminasi. Aloe vera contained an antioxidant enzyme that can inhibit the work of the mediators of inflammation and pain. With this research, however, will be measured the antioxidant enzyme activity of ascorbic dependent peroxidase and catalase on water extract Aloe vera and its potential as an anti-inflammatory on rat model wound contaminated. This research uses the post test only control group with simple random sampling techniques, with 36 rats were divided into two groups, namely the control and treatment groups. The control group (P0) is a control group and treatment group (P1)  is a group of mice with wounds contaminated given the wrap by using water extracts of Aloe vera 0.2 mg/g BB. In this study it was concluded that the antioxidant enzyme activity of activity of ascorbic dependent and catalase each 37.8 seconds-1 minute-1 and 3,145. In addition, the decrease in intensity of redness of erythema on the group that was given a water extract of Aloe Vera (Aloe vera) is faster than the control group. It can be concluded that the water extract of Aloe vera as anti-inflammatory potential in a mouse model of contaminated wounds.
Potensi ADP dan Katalase dalam Ekstrak Air Lidah Buaya (Aloe vera) sebagai Antiinflamasi pada Model Tikus Luka Terkontaminasi Agung Biworo; Windy Yuliana Budianto; Rismia Agustina; Eko Suhartono
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i1.1054

Abstract

Lidah buaya (Aloe vera) mengandung enzim antioksidan yang dapat menghambat kerja dari mediator inflamasi dan penghilang rasa sakit. Pada penelitian ini akan diukur aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase ekstrak air Aloe vera serta potensinya sebagai antiinflamasi pada tikus yang mengalami luka terkontaminasi. Penelitian ini menggunakan rancangan post test only control group dengan simple random sampling pada 36 ekor tikus yang terbagi atas 2 kelompok, yaitu kelompok kontrol (P0)  dan perlakuan (P1) merupakan kelompok tikus dengan luka terkontaminasi yang diberikan balutan dengan menggunakan ekstrak air lidah buaya 0,2 mg/g BB. Hasil penelitian menunjukkan bahwa aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase masing-masing 37,8 menit-1 dan 3,145 menit-1 dan rata-rata penurunan intensitas warna kemerahan dari eritema pada kelompok yang diberi ekstrak air lidah buaya (Aloe vera) lebih cepat daripada kelompok kontrol. Diismpulkan bahwa ekstrak air lidah buaya berpotensi sebagai antiinflamasi pada model tikus luka terkontaminasi. Aloe vera contained an antioxidant enzyme that can inhibit the work of the mediators of inflammation and pain. With this research, however, will be measured the antioxidant enzyme activity of ascorbic dependent peroxidase and catalase on water extract Aloe vera and its potential as an anti-inflammatory on rat model wound contaminated. This research uses the post test only control group with simple random sampling techniques, with 36 rats were divided into two groups, namely the control and treatment groups. The control group (P0) is a control group and treatment group (P1)  is a group of mice with wounds contaminated given the wrap by using water extracts of Aloe vera 0.2 mg/g BB. In this study it was concluded that the antioxidant enzyme activity of activity of ascorbic dependent and catalase each 37.8 seconds-1 minute-1 and 3,145. In addition, the decrease in intensity of redness of erythema on the group that was given a water extract of Aloe Vera (Aloe vera) is faster than the control group. It can be concluded that the water extract of Aloe vera as anti-inflammatory potential in a mouse model of contaminated wounds.
EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Iskandar Thalib; Windy Yuliana Budianto; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.562 KB) | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
Effect of Coal Dust Exposure on the SOD Activity and the Oxidative DNA Damage in Asthmatic Mice Windy Yuliana Budianto; Husnul Khotimah; Eko Suhartono
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.579

Abstract

BACKGROUND: Coal dust is known to trigger hypersensitivity and inflammation of the respiratory tract as it increases oxidative stress leading to asthma. To date, the relationship of coal dust exposure in the pathomechanism of asthma remains unclear. This study was aimed to examine the effect of coal dust exposure on the superoxide dismutase (SOD) activity and the oxidative DNA damage indicated by increased serum 8-hydroxy-2' -deoxyguanosine (8-OHdG) in asthmatic mice.METHODS: Twenty-four female balb/c mice were divided into four groups. The first group was the control group. The second group was the negative control group which composed of mice exposed to coal dust particles. The third group was composed of ovalbumin (OVA)-sensitized mice. The fourth group was composed of OVA-sensitized mice and exposed to coal dust particles. The inflammatory process was identified by serum interleukin (IL)-13 concentration using Enzyme-linked Immunosorbent Assay (ELISA) method. Meanwhile, the oxidative stress was examined by measuring the SOD activity using the Nitro Blue Tetrazolium (NBT) method, and the 8-OHdG concentration was quantified by ELISA method.RESULTS: There was an increasing IL-13 in OVAtreated coal dust exposed group along with the increment of 8-OHdG (statistically not significant). SOD activity measured in serum was decreased in all groups (p>0.05). Combination of OVA and coal dust showed the worst effect on IL-13, 8-OHdG and SOD activity.CONCLUSION: Coal dust exposure for four weeks does not adequately induce the oxidative DNA damage in asthmatic mice.KEYWORDS: asthma, coal dust, IL-13, SOD, 8-OHdG
Pelatihan Pembuatan Minumana Kesehatan Berbahan Jahe Merah dan Jintan Hitam pada Kelompok Ibu-ibu Pengajian Langgar Ar Rahman Banjarbaru Eko Suhartono; Edi Hartoyo; Windy Yuliana Budianto; Lisda Hayatie
Smart Society Empowerment Journal Vol 2, No 3 (2022): Smart Society Empowerment Journal
Publisher : Fakultas Kedokteran UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (987.677 KB) | DOI: 10.20961/ssej.v2i3.64135

Abstract

ABSTRAKPendahuluan: Jahe merah dan jintan hitam merupakan tanaman yang sudah lama digunakan untuk minuman herbal yang bermanfaat untuk kesehatan. Akan tetapi belum banyak masyarakat yang mengetahui cara pembuatannya. Berkaitan dengan tersebut,  dilakukan pelatihan kepada ibu-ibu kelompok pengajian Langgar Ar-Rahman Banjarbaru dengan tujuan memberikan edukasi dan ketrampilan cara pembuatan minuman kesehatan.Metode: Metode yang digunakan adalah induktif partisipatif secara kelompok, yang diikuti oleh 37 anggota kelompok pengajian. Pemberian  materi  melalui penyuluhan dan pelatihan. Materi yang diberikan mulai pemilihan bahan hingga membuat minuman kesehatan yang siap disajikan.Hasil dan Pembahasan: Kegiatan pelatihan pembuatan minuman kesehatan berbahan jahe merah dan jintan hitam berjalan dengan lancar. Para peserta antusias dalam mendengarkan pemaparan materi, dan aktif dalam tanya jawab seputar pembuatan pembuatan minuman kesehatan. Selain itu juga termotivasi untuk meningkatkan kesehatan dengan membuat dan mengonsumsi minuman kesehatan berbahan jahe merah dan jintan hitam.Kesimpulan: kegiatan ini adalah ibu-ibu anggota pengajian Langgar Ar-Rahman termotivasi untuk  membuat dan mengonsumsi minuman kesehatan berbahan jahe merah dan jintan hitam. Kata kunci: jahe merah; jintan hitam; minuman kesehatan ABSTRACTIntroduction: Red ginger and nigella sativa have long been used for herbal drinks that are beneficial for health. However, many people know how to make it. So that training is needed for members of the Langgar Ar-Rahman Banjarbaru recitation group. The aim is to provide education and skills on how to make health drinks.Method: The method used is participatory inductive in groups. The training was attended by 37 members of the study group. The material is given counseling and training. The material provided starts from the selection of ingredients to making health drinks that are ready to be served.Results and Discussion: The training activities ran smoothly. Participants are serious and actively participate in activities. In addition, they are also motivated to improve their health by making and consuming health drinks made from red ginger and black cumin.Conclusion: this activity is that the members of the Langgar Ar-Rahman recitation are motivated to make and consume health drinks made from red ginger and black cumin. Keywords: red ginger; black cumin; healthy drink
A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index Edi Hartoyo; Iskandar Thalib; Cynthia Maharani Puspita Sari; Windy Yuliana Budianto; Eko Suhartono
Journal of Tropical Life Science Vol. 7 No. 3 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.03.08

Abstract

The objectives of this study were to determine the involvement of Oxidative Stress (OS) in the pathogenesis of dengue hemorrhagic fever (DHF) through the analysis of oxidative stress Index (OSI). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity, and OSI were measured in 61 child dengue patients and (aged 6 months–18 years) with three different stages of DHF, i.e stage I, II, and III. The results show that the levels of MDA, SOD and CAT activity, and OSI significantly different between the group. The all parameters that investigated in this present study seems higher MDA level and OSI in the higher grade of DHF, except for SOD and CAT activity. From this result, it can be concluded that oxidative stress pathways might be involved in the pathomechanism of DHF and OSI might be used as a biomarker for OS and the severity in DHF patients.
Co-Authors Agung Biworo Agung Biworo Cahyadi, Herry Cynthia Maharani Puspita Sari Edi Hartoyo Edi Hartoyo Edyson Edyson, Edyson Eko Suhartono Eko Suhartono Eko Suhartono Eko Suhartono Fahira, Nurul Savira Husnul Khotimah Iskandar Thalib Lisda Hayatie Rismia Agustina Sekartaji, Hapsari Lintang