Journal of Pharmaceutical and Health Research
Vol 3 No 3 (2022): October 2022

C-4-metoksifenilkaliks[4]pirogalaril Dodekasinamat: Sintesis dan Uji Pendahuluan sebagai Bahan Aktif Tabir Surya

Harizal Harizal (Universitas Esa Unggul, Jakarta)
Jumina Jumina (Universitas Gadjah Mada, Yogyakarta)
Tutik Dwi Wahyuningsih (Universitas Gadjah Mada, Yogyakarta)

Article Info

Publish Date
30 Oct 2022

Abstract

Synthesis and preliminary study of C-4-methoxyphenyl[4]pyrogallaryl dodecacinnamate were successfully performed. Synthesis of target molecule was conducted in two steps including preparation of calix[4]pyrogallarene derivative, and O-cinnamoylation of the calix[4]pyrogallarene. The product obtained was pre-evaluated as sunscreen active compound through UV spectroscopy (UV absorbance profile, maximum wavelength, and molar absorption coefficient), and photostability tests. The results of evaluation indicated dominant absorbance in UVC/UVB region with exceptionally high molar absorption coefficient. In other side, target molecule has relatively low photostability in which the UV absorbance decreased 47% after 30 minutes irradiation. The main factor for this lowering was due to the close distance between each cinnamate groups.

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Journal Info
Journal of Pharmaceutical and Health Research
Website

Abbrev

jharma

Publisher

Forum Kerjasama Pendidikan TInggi

Subject

Health Professions Medicine & Pharmacology Nursing Public Health

Description

Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan ...