This study aims to determine the validity, response of students and know the integrated science module the human circulatory system as it relates to the Qur'an can foster religious attitudes of class VIII MTs. Development research using the Four D model developed by Thiagrajan. The findings of this research demonstrated that the integrated science module of the Qur'an on the subject matter of the human circulatory system obtained a percentage result of 73% from material experts with the "valid" category, The percentage result from media experts was 75% using the "valid" category, and integration experts (religion) obtained 92% of respondents rated it as "very valid,". The response of students to the integrated science module of the Quran on the subject matter of the human circulatory system obtained a percentage of 89% "religious"
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