Communications in Science and Technology
Vol 8 No 1 (2023)

Number of natural killer cells and cytokine levels in peripheral blood at various degrees of severity

Ninda Devita (Biomedical Sciences Programme, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia)
Adika Zhulhi Arjana (Clinical Pathology and Laboratory Medicine Department, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia)
Umi Solekhah Intansari (Clinical Pathology and Laboratory Medicine Department, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia)
Rina Susilowati (Histology and Cell Biology Departement, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia)



Article Info

Publish Date
11 Jul 2023

Abstract

This study aims to investigate NK cell number and cytokines level in various degrees of severity in COVID-19 cases. A total of 63 COVID-19 patient aged >18 y were divided into mild-moderate and severe-critical groups. Patient characteristics and peripheral blood count were obtained from medical records. NK cells number, levels of IFN-?, IL-10, and IL-12 in peripheral blood were examined by means of flow cytometry. The severe-critical group had leukocytosis, neutrophilia, lymphopenia, higher Neutrophil Lymphocyte Ratio, lower NK cell number and higher level of IL-10. In severe-critical group, those aged >60 years had higher IL-10. In both groups, patients with diabetes comorbidities had a higher number of NK cells (p<0.05). NK cell number and IL-10 in peripheral blood have potential as a predictor of severe COVID-19 patients.

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Journal Info

Abbrev

cst

Publisher

Subject

Engineering

Description

Communication in Science and Technology [p-ISSN 2502-9258 | e-ISSN 2502-9266] is an international open access journal devoted to various disciplines including social science, natural science, medicine, technology and engineering. CST publishes research articles, reviews and letters in all areas of ...