JIFI (Jurnal Ilmiah Farmasi Imelda)
Vol. 7 No. 1 (2023): Vol. 7 No. 1, September Tahun 2023

ANALISIS KADAR PARASETAMOL GENERIK DIBANDINGKAN BERMEREK DAGANG

Mariyani (STIFA Pelita Mas Palu)
Recky Patala (Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu)
Nurkhaliza Awilia (Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu)



Article Info

Publish Date
30 Sep 2023

Abstract

Paracetamol is a substance that can reduce the fever (antipyretic) and relieve the pain (analgesic). Analysis of the levels of generic and branded paracetamol tablets was carried out to determine whether the levels of the active substance in the preparations met the requirements or not by using the High Performance Liquid Chromatography method. The paracetamol quantitative test obtained the results of the levels in sample A = 94.306%, sample B = 99.986%, sample C = 95.296% and sample D = 94.904%. These results indicate that the level of the active substance paracetamol in each sample still meets the requirements of the Indonesian Pharmacopoeia Edition IV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid ChromatographyIV, namely not less than 90% and not more than 110%. Statistical analysis using the t-student test, the results of t-count < t-table (0.026 < 2.35) at a significant level of 5%, with the conclusion that there is no significant difference between generic paracetamol and branded paracetamol were analyzed using High Performance Liquid Chromatography.

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Journal Info

Abbrev

JURNALFARMASI

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Description

JIFI (Imelda Pharmacy Scientific Journal) Imelda Imelda College of Health Sciences (STIKes) which is now Imelda University Medan received related articles: 1. Clinical Community Of Pharmacy 2. Pharmaceutical Technology 3. Pharmacy Management 4. Herbal medicines and Chemistry 5. Biology & ...