MPI (Media Pharmaceutica Indonesiana)
Vol. 5 No. 2 (2023): DECEMBER

Antihypertension Activity of Averrhoa bilimbi Fruit Juice on Sodium Chloride and Prednisone-Induced Rats

Ari Yuniarto (Faculty of Pharmacy, Muhammadiyah A.R. Fachruddin University)
Dini Alviolita (Faculty of Pharmacy, Bhakti Kencana University)
Ika Kurniasukmawati (Faculty of Pharmacy, Bhakti Kencana University)
La Ode Akbar Rasydy (Faculty of Pharmacy, Muhammadiyah A.R. Fachruddin University)

Article Info

Publish Date
31 Dec 2023

Abstract

Hypertension is a condition where systolic and diastolic blood pressure continuously increases, causing heart disease, kidney disease, hardening of the arteries, eye damage, and stroke (brain damage). Bilimbi (Averrhoa bilimbi L.) is traditionally used to lowering high blood pressure. The research objective was evaluating the activity of A. bilimbi as an antihypertensive. The research was conducted in vivo using rats and the CODA blood pressure analysis instrument. The doses used for A. bilimbi juice were 150, 300, and 600 mg/kg BW, respectively. A. bilimbi juice at a dose of 600 mg/kg BW/day for 14 days can reduce systolic and diastolic blood pressure in male Wistar rats induced by 2.5% NaCl and 1.5 mg/kg BW prednisone. The results of the study showed that A. bilimbi juice at a dose of 600 mg/kg BW. had antihypertensive activity.

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Journal Info
MPI (Media Pharmaceutica Indonesiana)
Website

Abbrev

MPI

Publisher

Universitas Surabaya

Subject

Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Description

Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and ...