INDONESIAN JOURNAL OF PHARMACY
Vol 15 No 1, 2004

Characterization and dissolution studies of Furosemide solid dispersions using polyethylene glycol (PEG), talc and PEG-talc as dispersion carriers

Yandi Syukri (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia.)
Diny Rizayulianty (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia.)
Yuni Darty (Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia.)

Article Info

Publish Date
01 Jan 2005

Abstract

Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly dissolution rate.Key Word : furosemide, solid dispersion, dissolution

Copyrights © 2004




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Journal Info
INDONESIAN JOURNAL OF PHARMACY
Website

Abbrev

3

Publisher

Universitas Gadjah Mada

Subject

Medicine & Pharmacology

Description

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas ...