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All Journal INDONESIAN JOURNAL OF PHARMACY
Yuni Darty
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia.
Medicine & Pharmacology

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Characterization and dissolution studies of Furosemide solid dispersions using polyethylene glycol (PEG), talc and PEG-talc as dispersion carriers Yandi Syukri; Diny Rizayulianty; Yuni Darty
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.518 KB) | DOI: 10.14499/indonesianjpharm0iss0pp37-43

Abstract

Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly dissolution rate.Key Word : furosemide, solid dispersion, dissolution
Co-Authors Diny Rizayulianty Yandi Syukri