Current Biochemistry Journal
Vol. 2 No. 2 (2015)

In Silico Analysis of Curcuma longa Against PCAF Histon Asetiltransferase

Artha Vinsentricia (Institut Pertanian Bogor)
Djarot Sasongko Hami Seno (Institut Pertanian Bogor)
Maria Bintang (Institut Pertanian Bogor)

Article Info

Publish Date
03 Aug 2015

Abstract

Curcumin turmeric (C. longa) has been found capable of inhibiting p300/CBP associated factor (PCAF) histone asetyltransferase (HAT) as a cancer biomarker. However, the molecular mechanism of inhibition is unkown. This study is aimed to analyse the molecular inhibition mechanisms by in silico method. The analysis showed that curcumin’s Gibbs free energy (ΔG) was stable and capable of binding amino acid residues believed to be active site of PCAF HAT. Curcumin is predicted to be a PCAF HAT inhibitor, and further in vitro analysis is required.

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Journal Info
Current Biochemistry Journal
Website

Abbrev

cbj

Publisher

Institut Pertanian Bogor

Subject

Biochemistry, Genetics & Molecular Biology Education

Description

Current Biochemistry (CB) publishes the results of original research that contribute significantly to the understanding of the chemical compound and reaction that occur within living organism. Preference will be accorded to manuscripts that develop new concepts or experimantal approaches, ...