Indonesian Journal of Chemistry
Vol 17, No 1 (2017)

Application of Ion-Exchange Resin Column for Basic Development of Strontium-90/Yttrium-90 Generator for Preparation of Radiopharmaceutical Therapy

Muchtaridi Muchtaridi (Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Jatinangor KM 21-Sumedang 45363, West Java)
Elvan Kamal (Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Jatinangor KM 21-Sumedang 45363, West Java)
Anas Subarnas (Department of Pharmacology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Jatinangor KM 21-Sumedang 45363, West Java)
Abdul Mutalib (Department of Chemistry, Faculty of Mathematic and Natural Sciences, Universitas Padjadjaran, Jl. Jatinangor KM 21-Sumedang 45363, West Java)

Article Info

Publish Date
01 Apr 2017

Abstract

The aim of this study is to examine the possible use of ion-exchange resin on Dowex AG 50x8 in separating Y-90 from Sr-90 which then could be applied in the basic of manufacture of producing Sr-90/Y-90 generator for the production of radiopharmaceutical cancer therapy. The findings showed that a distributive coefficient of Sr-90 and Y-90 with HCl 6 N solvent showed that distributive coefficient of Sr-90 in cation-exchange resin on Dowex 50x8 was greater than Y-90. Y-90 in HCl 6 N solvent was more easily eluted, while Sr-90 was bound to resin.. In conclusion, resin on Dowex AG 50x8 with HCl 6 N elution solvent might be able to separate Y-90 from Sr-90 as the basis for Sr-90/Y-90 generator.

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Journal Info
Indonesian Journal of Chemistry
Website

Abbrev

ijc

Publisher

Universitas Gadjah Mada

Subject

Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...