Jurnal Kartika Kimia
Vol 1 No 1 (2018): Jurnal Kartika Kimia

Interaction of Several Calcon Compounds of Paracetamol Based Toward the Role of Enzyme Protein in Antibacterial Mechanism

Anasda Amal Fathullah (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman)
Wisnu Cahyo Prabowo (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman)
Rolan Rusli (Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)

Article Info

Publish Date
23 Nov 2018

Abstract

Kalkon is a secondary metabolite of the flavonoid group that is found in nature, especially in plants. Kalkon has various activities such as cytotoxic, antiviral, anesthetic, antimicrobial, antiinflammatory, and so forth. The aim of this research is to know the antibacterial activity of kacco-based derived paracetamol compound by using docking method against bacterial protein Escherichia coli and Bacillus subtilis. The results showed that the compound 3- (4-Metoxyphenyl) -N- (4-Chlorophenyl) Acrylamide, 3- (4-Hydroxyphenyl) -N- (4-Chlorophenyl) Acrylamide, and 3- (4-Hydroxy-3-Methoxyphenyl ) -N- (4-Chlorophenyl) Acrylamide showed good activity with an average rmsd-refine score <2. The kalkon derivative binds complex with amino acid bacteria such as Ile 173, Asn 267, Lys A449, Thr 265, and Arg A389.

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Journal Info
Jurnal Kartika Kimia
Website

Abbrev

jkk

Publisher

Universitas Jenderal Achmad Yani

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education

Description

Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also ...