<![CDATA[Objective: To know the correlation between Hypoxia Inducible Factor
(HIF)-1α level with preeclampsia.
Method: The study was conducted at the Obstetrics and Gynecology
Department of Prof. Dr. R. D. Kandou Hospital. This research was
carried out from April to June 2014. This study is a cross-sectional
analytic approach in preeclampsia and normotensive pregnancy. We
perform cubital venous blood sampling for inspection by 5 ml of serum
and stored it in a refrigerator (-20°C). The level of HIF-1α serum
was done by quantitative ELISA method in Prodia Lab Jakarta.
Result: Seventy six pregnant women with 38 normotensive pregnancies
and 38 preeclampsia, showed a significant association between
the average levels of HIF-1α in the serum of pregnant women
with preeclampsia compared to normotensive pregnancies (p =
0.000).
Conclusion: There is a positive relationship between the levels of
HIF-1α in serum of preeclampsia, in which HIF-1α levels in preeclampsia
was higher than normotensive pregnancies.
[Indones J Obstet Gynecol 2016; 1: 19-22]
Keywords: hypoxia inducible factor-1α, preeclampsia]]>
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