Paediatrica Indonesiana
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
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Lipid profiles of vegetarian and non-vegetarian children at risk of overweight or obesity
Arie Purwana;
IKG Suandi;
Endy Paryanto Prawirohartono
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.291-4
Background The type, amount, and composition of a diet may affect the levels of cholesterol in blood. Itis believed that children adhering to a vegetarian diet have lower total cholesterol levels and lower body mass indexes compared to children with non-vegetarian (omnivorous) diets. We wish to compare cholesterol levels of vegetarian and non-vegetarian Indonesian children who are at risk of overweight or obesity.Objective To compare lipid profiles of vegetarian and no-vegetarian children who are at risk for overweight or obesity.Methods We performed a cross-sectional study in January and February 2010. Subjects for this study came from Denpasar, Bali. Subjects filled questionnaires as well as underwent history-taking, anthropometric measurements, and blood testing. We performed lipid profile analyses on their blood samples. We used the independent t test and Mann-Whitney test for statistical analysis of the data. The level of significance was set at P <0.05.Results Our study included forty-four children at risk for overweight or obesity with a vegetarian or non-vegetarian diet. We found that vegetarian children had lower mean total cholesterol (144 mg/dL) than that of non-vegetarian children (171 mg/dL), a statistically significant difference of P=0.014. In addition, vegetarian children had lower mean triglyceride levels (150 mg/dL) than those of non􀀶vegetarian children (264 mg/dL), a statistically significant difference of P =0 .025.Conclusion Among Balinese children at risk of overweight or obesity, vegetarians have significantly lower mean total cholesterol and triglyceride levels than non-vegetarians.
Rupture of esophageal varices due to portal hypertension
Yusri Dianne Jurnalis;
Yorva Sayoeti;
Marlinda Marlinda
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.316-20
Variceal bleeding is the most common cause of serious upper gastrointestinal (UGI) bleeding in children. Most variceal bleeding is esophageal.1 Hemorrhages from esophageal varices due to portal hypertension are a major cause of morbidity and mortality. There is a 30% mortality rate following an initial episode of variceal hematemesis. Mortality increases to 70% with recurrent variceal hemorrhage. Moreover, the one year survival rate after variceal hemorrhage is often poor (32 to 80%).2-4 We report a case of esophageal varices rupture caused by portal hypertension, an emergent case in the Pediatric Gastrohepatology division.
Comparison of metabolic syndrome criteria in obese and overweight children
Astrid Anastasia Malonda;
Helena Anneke Tangkilisan
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.295-9
Background Metabolic syndrome (MS) is a group of disorders which occur in relation to increasing body weight. Only a few studies have reported the differences in the fulfillment of MS criteria between obese and overweight children, and none were from Indonesia.Objective To detennine the differences in metabolic syndrome disorders between obese and overweight children.Methods A cross-sectional study was conducted in Manado from May to August 2010. The diagnosis of MS is established by fulfilling three of five criteria: waist circumference  ≥90th percentile, blood pressure ≥ 90th  percentile, fasting blood sugar (FBS) ≥ 100 mg/dL, triglycerides  ≥110 mg/dL and high density lipoprotein (HDL) ≤40 mg/dL. Obesity was defined as body mass index (BMI) of> 3 SD and overweight as BMI of 2-3 SD. Results Results ere analyzed by x2 and t-test. Results Thirty obese and 30 overweight children aged 10-14years were examined for the disorders of MS. Twentyô€„three obese and 4 overweight children had waist circumferences  ≥90th percentile. Seventeen obese and 3 overweight children had blood pressure  ≥90th percentile. No significant differences in FBS, HDL, and triglycerides were observed between the two groups. Thirteen obese children met the MS inclusion criteria, while only 1 overweight child did so (P<0.001).Conclusions High blood pressure (≥90th percentile) and waist circumference (≥90th  percentile) occurred were observed at higher frequency in obese children than in overweight children. The occurrence of MS in obese children was significantly higher than in overweight children.
Urine specific gravity as a diagnostic tool for dehydration in children
Kalis Joko Purwanto;
Mohammad Juffrie;
Djauhar Ismail
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.269-73
Background Using clinical judgment to diagnose dehydration can be highly subjective. To diagnose dehydration, it would be ideal to have an accurate, inexpensive, objective and easy-to-perform diagnostic tool. In cases of dehydration, plasma osmolality rises, causing an increase in antidiuretic hormone (ADH) secretion. The increased ADH reduces urine production and increases urine osmolality. Previous studies have show that urine osmolality correlates well to urine specific gravity. We investigated if urine specific gravity can be a reliable and objective detennination of dehydration status.Objective To assess the accuracy of using urine specific gravity as a diagnostic tool to determine dehydration status of children with diarrhea.Methods We conducted the study in the pediatric ward of Sardjito Hospital from September 2009 to December 2009. Using a refractometer we measured urine specific gravity from patients with diarrhea. This measurement was then compared to a standard of acute body weight loss, with dehydration defined as weight loss of 5% or more. The cut-off value for defining dehydration using specific gravity measurements was detennined by a receiver-operator curve (ROC).Results Out of 61 pediatric patients who were recruited in this study, 18 (30%) had dehydration as defined by a body weight loss of 5% or more. Based on the ROC, we determined the cut off value for urine specific gravity to be 1.022. Using this value, urine specific gravity was 72% sensitive (95% CI 52 to 93), and 84% specific (95% CI 73 to 95) in determining dehydration status.Conclusion Urine specific gravity is less accurate than clinical judgment in determining dehydration status in children with diarrhea.
The management of vesicoureteral reflux in children
Nurul Akbar;
Arry Rodjani
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.259-68
Vesicoureteral reflux (VUR) is defined as retrograde flow of urine from the bladder to the ureter. Â It is usually asymptomatic but commonly found in children with urinary tract infection (UTI). The prevalence is about 1-2% in general pediatric population.1 However, the prevalence in children with UTI is much higher, reaching 30-57%.1,2 Similar prevalence (45.8%) is also reported in CiptoMangunkusumo Hospital. 3
Acanthosis nigricans and insulin resistance in obese children
Kristellina Sangirta Tirtamulia;
Adrian Umboh;
Sarah Maria Warouw;
Vivekenanda Pateda;
Frecillia Regina
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.274-7
Background Acanthosis nigricans (AN) is a skin condition characterized by darkening and thickening of skin. AN has been reported to be linked to insulin resistance (IR), that associated with type 2 diabetes, in obese children in many country.Objective To determine the relation between acanthosis nigricans and insulin resistance in obese children.Methods We conducted a cross sectional study in Wenang District, Manado, from October 2009 until January 2010. We examined 54 obese children aged 10-14 Â years for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). We analyzed the results byT-test and phi coefficient correlation. The value of P
Effect of nutritonal therapy on Helicobacter pylori infections in severely malnourished children
Mahdin A. Husaini;
Jajah K. Husaini;
Susie Suwarti;
Yekti Widodo Heryudarini Harahap
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.278-83
Background Severe malnutrition young children has been a problem in Indonesia for many years. In recent years the condition may be increasing. Besides a lack of nutrition, H. pylori infection may contribute to this condition.Objective To determine if severely malnourished children have high rates of H. pylori infection, and to test if improving nutritional deficiency by drinking skimmed milk can reduce the number of H. pylori cases.Methods A total of 83 children aged 6 - 36 months with severe malnutrition (weight-for-age < -3 Z-scores), who were outpatients at the Nutrition Clinic in fugor served as subjects for this longitudinal study. Out of 83 children, 42 subjects (50%) tested positively for H. pylori infection (Group P) and 41 subjects  (49.4%) tested negatively (Group NP). All subjects received the same nutritional intervention consisting  of medical care, 250 g of skimmed milk, and guidance concerning proper feeding and care of children at every clinic visit, for a duration of 6 months.Results The study revealed that after 6 months of nutritional intervention, the percentage of children suffering from diarrhea was significantly (P < 0.05) reduced in Group P, while no significant change was demonstrated in Group NP. The nutritional intervention also demonstrated a noticeable effect on the incidence of H pylori infection, reducing the number of H. pylori infections by 29% in Group P. In Group Np, 100% of the children remained free of H. pylori infection after intervention. No new cases of H. pylori infection appeared in either group. An improvement in nutritional status was also observed: 23.8% of severely undernourished children in Group P and 3 4.1 % in Group NP improved after intervention.Conclusion Drinking skimmed milk twice daily, as well as parental counseling on proper feeding and child care, led to improved nutritional status of severely malnourished children. We also observed that skimmed (non-fat) milk may have a role in preventing and treating malnourished children with H. pylori infection.
Reflux esophagitis in children with feeding problems: A preliminary study
Lia Mulyani;
Badriul Hegar;
Alan R. Tumbelaka;
Ening Krisnuhoni
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.284-90
Background Untreated gastroesophageal reflux can cause reflux esophagitis, a condition characterized by damage to the esophageal mucous layer due to exposure to caustic gastric contents. Manifestation of esophagitis in young children include feedingproblems, irritability, and back􀀳arching. Persistent esophagitis may cause growth failure, gastric bleeding, and anemia. Reflux esophagitis should be considered an etiology of feeding problems, especially in children with a history of gastroesophageal reflux during infancy.Objective The purpose of this study is to detennine the prevalence of reflux esophagitis in children with feeding problems.Methods A cros-sectional study was done in November 2007 to April 2008. Children under 5 years of age with feeding problems and a history of regurgitation or vomiting started from age 6 months or more underwent endoscopy and biopsy examinations. Reflux esophagitis was diagnosed based on the Los Angeles classification of endoscopic examination.Results Reflux esophagitis was diagnosed in 18 of 21 children with feeding problems and a history of regurgitation or vomiting. Most subjects were boys aged 12 to36 months. Feeding problems has lasted for more than 6 months, regurgitation or vomitingfor more than 12 months, and suffered from mild malnutrition. Vomiting was observed to be a common symptom in children with reflux esophagitis.Conclusion The prevalence of reflux esophagitis in children with feeding problems and a history of regurgitation or vomiting started from age ≥ 6 months is high, therefore it will influence treatment.
Predicting hypertension using waist circumference in obese Indonesian adolescents
Elvietha Alamanda;
Endy Paryanto Prawirohartono;
Nenny Sri Mulyani
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.300-4
Background Increasing prevalence of pediatric obesity and hypertension demonstrate the urgent need for early intervention. Waist circumference (WC) provides a measurement of central obesity, which has been specifically associated with cardiovascular risk factor including hypertension.Objectives To identify the optimal cutô€€¹off point of we in predicting hypertension in obese adolescents.Methods We randomly recruited 115 adolescents aged 12-17 years from schools in Yogyakarta, Central Java, Indonesia. We measured height, weight, WC, and blood pressure in 109 subjects. Optimum WC cut-offs to predict hypertension were determined using receiver-operating characteristic (ROC).Results The optimum WC cut off point to predict any hypertension in adolescents was at the 88.95 cm with 97.8% sensitivity and 47.3% specificity. Ageô€€¹specific cutô€€¹off points for subjects < 15 year old was 90.1 cm with 91.7% sensitivity and 58%specificity, and for subjects 2: 15 year old was 103.5 cm with 75% sensitivity and 88% specificity.Conclusions Waist circumference can be used to predict hypertension in obese adolescents with fair sensitivity and specificity. Waist circumference values associated with hypertension in adolescents vary with age and ethnicity.
Accuracy of modified simple pediatric nutritional risk score to detect in-hospital malnutrition
Ni Nyoman Metriani Nesal;
Gusti Lanang Sidiartha;
Endy Paryanto Prawirohartono;
Kompiang Gede Suandi
Paediatrica Indonesiana Vol 50 No 5 (2010): September 2010
Publisher : Indonesian Pediatric Society
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DOI: 10.14238/pi50.5.2010.305-9
Background In-hospital malnutrition is malnutrition that occurs during hospitalization. Approximately 70% patients with in-hospital malnutrition are not identified. Only few nutritional screening tools are widely used among children , one of those is the modified risk score.Objective To determine cutoff point and accuracy of risk scores using the modified simple nutritional risk score to detect in-hospital malnutrition.Methods A diagnostic study on 1 month-12 year old children hospitalized at Sanglah Hospital Denpasar was conducted between September-December 2008. The subjects were collected using consecutive sampling method and were assessed using the modified simple pediatric nutritional risk score. In􀀿hospital malnutrition was defined days), 5% (length of stay 8-30 days), or 10% (length of stay >30 days). The statistical analyses done were sensitivity, specificity, positive/negative predictive value (PPV /NPV), positive/negative likelihood ratio (PLR/NLR), and post-test probability.Results This study recruited 310 children. Based on ROC curve, the cutoff point \\lith combination of the highest sensitivity and spesificity the sensitivity was 79%, spesificity was 92%, positive likelihood ratios was 2.71, negative likelihood ratio was 0.29 , and post test probality was 47%.Conclusion The modified simple pediatric nutritional risk score can be used as a screening tool to detect in􀀿hospital malnutrition.