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INDONESIA
BIOEDUSCIENCE
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 2614154X     EISSN : 26141558     DOI : -
Core Subject : Science, Education, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education
BIOEDUSCIENCE is an open access journal that publishes research in the field of Biology and Biosain Education such as: Applied and implemented in education and learning, Botany, Zoology, Microbiology, Ecology, Biotechnology, Molecular Biology, Genetics, Bioinformatics, Cell and Developmental Biology, Biodiversity and Bioconservation. BIOEDUSCIENCE is published by Biology Education Study Program, Universitas Muhammadiyah Prof. Dr. Hamka, Indonesia regularly in June and December. ISSN : 2614-1558; P-ISSN : 2614-154X.
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Articles 39 Documents
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Search results for , issue "Vol 6 No 1 (2022): BIOEDUSCIENCE" : 39 Documents clear
Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma Rahul Simon Situmeang; Gim Mi Kyong; Rosiva Betaria Purba; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.256 KB) | DOI: 10.22236/j.bes/618095

Abstract

Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.
Gastropoda Diversity in Polyculture Agricultural Ecosystem of Nansean Village, Insana District, North Central Timor Regency- East Nusa Tenggara Province (NTT) Blasius Atini; Aloysius Rusae
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.438 KB) | DOI: 10.22236/j.bes/618539

Abstract

Background: The research was carried out in the polyculture area of Nansean Village, North Central Timor Regency. This study aims to determine the diversity of Gastropoda species and also to determine the influence of environmental factors on the Gastropoda life in the polyculture agricultural ecosystem of Nansean Village. Methods: The method used in this research is the quadratic method by placing plots along the transect line. The data analysis technique for Gastropoda diversity was using the Shannon-Winner diversity formula. Results: From the results of the study, it was found that 6 types of Gastropoda namely Achatina fulica with a diversity index (H') of (3.51) were classified as high. Laevicaulis alte Bowd with a diversity index (H') of (1,15) was classified as moderate. Felicaulis sp with a diversity index (H') of (1,25) was classified as moderate, Bradybaena similaris Frussac with a diversity index (H') of (1,26) was classified as moderate. Achatina variegata Bowd with diversity index (H') of (0.92) is low. Doraceras leave sp with a diversity index (H') of (0.87) is low. Species diversity shows the pattern of adaptation to ecosystem conditions is quite good, and vice versa if the type of Gastropoda is low. Conclusions: the environment has a role in diversity variations in Nansean Village, Insana District, and North Central Timor Regency.
Konsentrasi Logam Berat Cd, Hg, Pb pada Produk Pangan Olahan Berbahan Dasar Pterygoplichthys pardalis (Castelnau, 1855) asal Sungai Ciliwung Wilayah Jakarta Dewi Elfidasari; Haninah Haninah; Handhini Dwi Putri; Irawan Sugoro
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (938.824 KB) | DOI: 10.22236/j.bes/618708

Abstract

Backgrounds: Heavy metal that pollutes the river area affects living organisms which reside in it. Contamination of heavy metal in Ciliwung River leads to the presence of heavy metal elements (Cd, Hg, and Pb) inside the body of the plecos (Pterygoplichtys Pardalis) which inhabits that area. Hence, the utilization of plecos flesh and bones as a raw material in processed food products (e.g. shredded fish, shumai, and fish flour) might be harmful for human. Accumulated load of heavy metal in human's body would likely trigger health problems. Insufficient data on heavy metal concentration in Ciliwung River plecos-based food products underlies this research, with the aim to calculate the concentration of heavy metal Cd, Hg, and Pb on the previously mentioned plecos-based shredded fish, shumai, and flour. Methods: Heavy metal Cd, Hg, and Pb concentration analysis using X-Ray Fluoresence (XRF) methods conducted on PAIR Batan. Results: Value of Cd on shredded fish <0.5 mg/kg, shumai 0,7 mg/kg, head+tailbone and body skeleton flour <0.3 mg/kg. Value of Hg on shredded fish and shumai <0.7 mg/kg, head+tailbone flour 0.3 mg/kg, body skeleton flour 0.4 mg/kg. Value of Pb on shredded fish 1.3 mg/kg, shumai 0.8 mg/kg, head+tailbone flour 2.3 mg/kg, body skeleton flour 1.6 mg/kg. Conclusions: Heavy metal concentration on Ciliwung River plecos-based processed food products (shredded fish, shumai, and flour) has exceed maximum limit of Cd, Hg, and Pb determined by SNI, BPOM, and FAO.
Investasi Hama Penggerek Pucuk Kelapa (Oryctes rhinoceros) Pada Plasma Nutfah Agave Parnidi Parnidi; Dwi Adi Sunarto; Marjani Marjani
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/616282

Abstract

Background: Agave is known as one of the natural fiber-producing plants that have many benefits. Agave plants can grow well on dry land, however, many organisms can damage agave crops in the field. One of the agave plant is Shoot Borers Beetle Pest of Coconut (Oryctes rhinoceros L). The purpose of this research is to get information about variation damage of agave germ plasma to Shoot Borers Beetle Pest of Coconut (Oryctes rhinoceros L). Methods: The research was conducted at the Agave balittas collection in the Experimental Garden Balittas Karangploso. Observation of shoot borers beetle pest of coconut (Oryctes rhinoceros L.) was carried out on 6 plants. Observations were made by calculating the number of holes that were found on the leaves. Results: The results showed that the investment of Shoot Borers Beetle Pest of Coconut (Oryctes rhinoceros L) causing damage to agave germplasm varies. The average percentage of damage to Agave angustifolia and Agave cantala in 2017 due to the investment in Shoot Borers Beetle Pest of Coconut (Oryctes rhinoceros L) is range from 66.7 to 100%. The average damage caused by Shoot Borers Beetle Pest of Coconut (Oryctes rhinoceros L) investment in Agave sisalana ranges from 0 to 16.7%. Conclusions: The investment of shoot borers beetle pest of coconut in agave plants has a big impact on decreasing crop production and fiber quality.
Diversity and Potential of Flowering Plants in Timau Mutis Nature Reserve, Tasinifu Village Ite Morina Yostianti Tnunay; Florian Mayesti Prima R. Makin; Welsiliana Welsiliana
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/616923

Abstract

Background: The mountain ecosystem in Mutis Timau Nature Reserve, Oelmuke Village, has a high diversity of flowering plants but has not been recorded. Inventaritation of the flowering plant provides reference information for area conservation. This study aims to inventory the types and uses of flowering plants by the community and other potential benefits in the Mutis Timau Nature Reserve, Oelmuke Hamlet, East Nusa Tenggara. Method: This research was conducted in August 2019 in Oelmuke Village, East Nusa Tenggara. The plant collection was conducted using an experimental method along the Oelmuke Village area. The information on the use of flowering plants by the community using the interview method and information about other potential uses using the literature review method. Result: The flowering plants inventoried from Oelmuke Village is 31 species from 15 families that have been used as food, animal feed, building materials, medicinal materials, ornamental plants, hedge plants, firewood, and cigarette raw materials, and textile materials. Other potential uses are as an accumulator of Pb waste and dye for woven fabrics. Conclusions: The 31 species of plants that have been inventoried have been used by the community as food, animal feed, building materials, medicinal materials, ornamental plants, hedges, firewood, cigarette raw materials, and textile materials and other potential uses are accumulator Pb waste and dyes for woven fabrics
Guided Inquiry-Based Electronic Module Development on Circulation System Ma-Terial to Improve Student Learning Outcomes Madiany Erika Purnama; Saleh Hidayat; Rusdy A. Siroj
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617089

Abstract

Background: Industrial era 4.0 has an impact on the world of education. This affects students, where students can understand subject matter such as biology, which contains abstract concepts such as circulation system material. The teaching materials developed in this study are expected to improve student learning outcomes by integrating guided inquiry learning models. This study aimed to determine the validity, practicality, and effectiveness of guided inquiry-based electronic modules. Method: 4D model development research. Data collection by interview and questionnaire sheet. Result: The module validation of the language validator is 83%, the material is 81%, the media 81% has a good category, while the learning device validator is 96%, the learning validator is 98%, and 94% has a very good category. Practicality is taken from student responses which are divided into three stages: 81% preliminary trial, 89% quantitative trial, and 92% final trial showing a positive response. The effectiveness of this guided inquiry-based electronic module can improve student learning outcomes seen from the N-Gain score results. The control class is 0.38 with medium criteria, and the experimental class is 0.73 with high criteria. While the psychometric results of students who studied using guided inquiry-based electronic modules for three meetings, namely the first meeting 77% (good), the second meeting 91% (very good), and the third meeting 88% (very good). Conclusion: Guided inquiry-based electronic module on circulation system material has a potential effect on improving student learning outcomes
Pengembangan Booklet Kelainan Sistem Peredaran Darah Disertai Pengayaan Uji Aktivitas Antidislipidemia Ekstrak Daun Salam Nur Dwi Handarsiputri; Titin Titin; Wolly Candramila
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617418

Abstract

Background: Media booklets are media used in the learning process that have advantages in supportive conditions. The booklet contains a summary of the material that is equipped with pictures and colors so that it is interesting. This study aims to develop a booklet with enriched information about the antidyslipidemic activity test of bay leaf extract (Syzygium polianthum (Wight) Walp.) as a learning medium in the Sub Material of Circulatory System Abnormalities for second grade of highschool. Methods: This development research uses the type of research and development (R&D). The development stages include potentials and problems, data collection, product design, design validation, design revision, and product. The media booklet was validated by 5 validators in terms of format, content, and language, all of which covered 9 criteria. Results: Validation obtained Content Validity Ratio (CVR) and Content Validity Index (CVI) values "‹"‹of 1 which meet the minimum criteria for content validity. Conclusion: Thus, the booklet enriched with the results of the antidyslipidemic activity test of bay leaf extract (Syzygium polianthum (Wight) Walp.) was declared content valid as a learning medium in the Circulatory System Abnormalities Submaterial.
Penanganan Epilepsi Grand Mal Sebagai Akibat dari Ketidaknormalan Kerja Neuron di Otak Menggunakan Metode Diet Ketogenik Nommensen Pangihutan Ompusunggu; Sabar Manampin Giawa; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617688

Abstract

Background: The nervous system is composed of a complex structure to support its highly organized work. Damage to the working mechanism of nervous systems can exert fatal impacts to the human body. One of the consequences of damage to the mechanism of action potentials is grand mal epilepsy. The purpose of this paper is to determine the structure, function, and mechanism of action of neurons, establish grand mal epilepsy as a result of damage to the working mechanism of neurons, and recognize the ketogenic diet as a non-pharmacological therapy for epilepsy patients. Methods: The research method used is descriptive qualitative research. Results: Nerve cells generally consist of dendrites for receiving stimuli, cell bodies for transmitting stimuli to the axon, and axons for transmitting stimuli to other nerve cells. Grand mal epilepsy is a nervous system disorder caused by the increased activity of sending electrical waves throughout the brain that can reach up to four times faster than normal. However, grand mal epilepsy patients suffer from an excessive number of seizures that may occur at any time. Conclusions: The ketogenic diet method is a high-fat and low-carbohydrate diet method that can reduce electrical activity in the brain. Ketone-containing fats have a stabilizing effect on the central nervous system, contributing to anticonvulsant and antiepileptic effects that may reduce the excessive number of seizures experienced by patients. The application of this diet should be balanced with the provision of additional intake of multivitamins, minerals, and fiber to balance the nutrients the body needs.
Identifikasi Pemanfaatan Tanaman Obat Desa Kasiyan Kecamatan Puger sebagai Bahan Penyusun Booklet Dini Nurmawati; Diah Sudiarti; Haning Hasbiyati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617819

Abstract

Background: Indonesia is a country that has many types of plants, one of which is medicinal plants, Kasiyan Village is a village located in the Puger district, Jember district, this village grows a lot of plants that are used as medicine by the local community, the purpose of this study is to identify the types of medicinal plants part of the population. as well as how to use it by the people of Kasiyan Village, it is hoped that this can enrich biology learning resources packaged in the form of booklets. Results: There are 47 species of medicinal plants from 25 families that are found in the family Euphorbiaceae. The part of the plant that is widely used is the leaf part with a percentage of 40%. How process plants that are often used is boiled with a percentage of 29%. Conclusions: Medicinal plants have properties that can be used as a treatment of diseases considering the many properties obtained from this medicinal plant for the body not only that this medicinal plant more natural and more efficient.
Pengaruh Penggunaan Zat Pengatur Tumbuh Alami terhadap Perkecambahan Biji Cabai Katokkon Reisky Megawati Tammu; Jessica Elfani Bermuli
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617853

Abstract

Background: Katokkon is a local red pepper that is widely cultivated in the North Toraja Regency and several surrounding areas within the scope of South Sulawesi Province, Indonesia. This pepper has a spicy taste and a unique fruit shape like paprika in small size and is rich in nutrients such as ascorbic acid, carotenoids, and capsaicin so that it benefits human health and serves as one of the commodities that improve the people's economy. Katokkon pepper is adapted to grow well in upland areas so that cultivation outside this habitat requires certain efforts to be optimal. Seed germination is an important step in plant cultivation. Coconut water and shallots extract were commonly used as sources of growth regulators substances to stimulate seed germination. Therefore, this study aims to determine the effect of natural growth regulators substances on the Katokkon pepper seed germination. Methods: This study was conducted by a factorial randomized block design with two factors and three replications. The Katokkon pepper seeds were soaked in the 25%, 50%, and 75% of coconut water and shallots solution for 24 hours. Results: The treatment of coconut water with a concentration of 75% (ZAK3) has a significant effect on the percentage and speed of seed germination of Katokkon pepper. Conclusions: The greater concentration of natural growth regulators used, the greater the percentage of seed germination obtained. However, the effect of coconut water treatment on seed germination of Katokkon pepper was more significant than the shallots extract.

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