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INDONESIA
Journal of Pharmacopolium
Published by STIKes Bakti Tunas Husada
ISSN : 26208563     EISSN : 26211521     DOI : -
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Other
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue " Vol 1, No 1 (2018)" : 6 Documents clear
FATTY ACID ANALYSIS OF MARINE MICROALGAE Chlorella Sp. IN MODIFIED MEDIUM USED GAS CRHOMATOGRAPHY-MASS SPECTROMETRY (GC-MS) Kurnia, Dewi
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Microalgae is known as a raw materials of pharmaceutical industry, it contains various chemical compounds such as protein, fatty acid, pigments and vitamins. The compound can be use as a basic ingredient of pharmaceutical also can be use as a treatment or prevention agent such as cancer and high cholesterol. Chlorella sp. is a green microalgae which can be found in Indonesia marine area, it also has a high enough of lipid. Compotition of fatty acid from marine microalgae Chlorella sp that cultivated with modification medium has been analyzed. Microalgae culture cultivated with GM 10% as a medium for 8 days. 51,55 L culture produced a 31,0537 gr dry biomass. 31,0537 gr dry biomass Soxhletation produced about 12,8818% w/w oil rendemen. The results of GC-MS analysis, there are 3 types of fatty acids identified in microalgae Chlorella Sp. The composition are palmitic acid (13,34%), linoleic acid (5,39%) and oleic acid (16,40%). Total fatty acid contained is 35,13% Keywords:Chlorella sp, fatty acids, GC-MS.
SKRINING AKTIVITAS ANTIBAKTERI FRAKSI EKSTRAK ETANOL KERNEL BIJI BUAH LIMUS (Mangifera foetida Lour.) TERHADAP Staphylococcus aureusDAN Escherichia coli Nurviana, Vera
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Limus (Mangifera foetida Lour.) Is one of the local Indonesian fruits of the anacardiaceae family. Limus contain secondary metabolites that have pharmacological effects, including the kernel waste of the seeds of the fruit. This study aims to determine the antibacterial activity against Staphylococcus aureus and Escherichia coli on the fraction of kernel seed of limus fruits ethanolic extract in invitro using solid diffusion method with positive control Tetracycline HCl. The extraction process was carried out by maceration method, then fractionation was obtained to obtain the fraction of n-hexane, ethyl acetate fraction and water fraction. Based on the result of the research, the fraction of n-hexane, ethyl acetate fraction, and water fraction of kernel ethanol extract limus fruit seed have antibacterial activity against Staphylococcus aureus and Escherichia coli. The highest activity was shown by fraction of ethyl acetate with minimum killing concentration (KBM) to Staphylococcus aureus was 5% with diameter equal to 4,33 ± 1.17 mm equal to 30,27 μg / mL Tetracycline HCl, and KBM value to Escherichia coli.4% (7.60 ± 0.14) mm equivalent to 26, 04 μg / mL Tetracycline HCl. Keywords: Antibacterial, Staphylococcus aureus, Escherichia coli, Kernel, M. foetida.
IDENTIFIKASI BAKTERI POTENSIAL PADA FASE PEMATANGAN KOMPOS MANUR Fatmawati, Fenti
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Pengomposan merupakan salah satu sumber dalam mencari mikroorganisme potensial penghasil enzim Selama proses pengomposan, terjadi perubahan komunitas mikroorganisme yang disebabkan oleh beberapa faktor seperti perubahan suhu. Proses pengomposan pada penelitan ini terbagi menjadi 5 tahap pengomposan yaitu fasa inisiasi/ awal pengomposan (suhu pengomposan 28oC), mesofilik pertama (suhu 50 oC), termofilik (suhu 55 oC), mesofilik kedua (suhu 50 oC) dan fasa pematangan (suhu 37 oC). Tujuan dari penelitian ini adalah untuk mengidentifikasi bakteri potensial yang dapat menghasilkan enzim amilase, selulase, xilanase dan lipase pada fase pematangan/ fase akhir pada proses pengomposan manur sapi. Dari hasil penelitian didapatkan bakteri F5A yaitu bakteri potensial dari hasil fase pematangan/fase akhirkompos manur sapi.  Bakteri ini sangat potensial karena memiliki aktivitas amilase, selulase, xilanase dan lipase. Dari hasil analisis filogenetik diketahui bahwa bakteri F3A memiliki homologi terdekat dengan Viridibacillus arenosi dengan kemiripan 98%. Kata Kunci:   Amilase, Lipase, Selulase, Xilanase, Viridibacillus arenosi
ISOLASI ZAT WARNA BARU Monascus purpureus DARI HASIL FERMENTASI PADAT DENGAN BERAS SEBAGAI SUBSTRAT Yuliana, Anna
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Monascus purpureus is a mold capable of producing pigment as secondary metabolites. Pigments of Monascus purpureus isolated from rice fermented solid known as red yeast rice. This study was conducted toMonascus purpureus know the potential in generating new compounds of pigment produced by solid fermentation process with rice as a substrate. The results indicate insulation compounds and new compounds of pigment Monascus purpureus. Beginning with an analysis of Thin Layer Chromatography (TLC) using the mobile phase n-hexane and ethyl acetate (7:3) with a Rf value obtained was 0.71. Analysis with UV-Vis spectrophotometry against red yeast rice extract aims to determine the maximum wavelength. The results of the analysis of UV-Vis spectrophotometry obtained one peak an absorption at 0.255 with a wavelength of 486 nm which showed that the red pigment monascorubramin compounds in Monascus purpureus. Isolation of Monascus purpureus pigments by Preparative Thin Layer Chromatography (Preparative TLC) using the mobile phase n-hexane and ethyl acetate (7:3). Results isolation pigment Monascus purpureus form of a ribbon that can fluoresces atλ 365 nm UV light with a Rf value obtained was 0.73 were further identification of the molecular weights of compounds Monascus purpureus using HPLC instruments with detectors MS (Mass Spectrometer). The results of LC-MS analysis of a sample INACC-F01 showed a new compound which has a molecular weight of 357.41 and based on the literature that the same compounds with molecular weight is Monascopyridine C which is a derived compound from Monascus red pigment that is monascorubramin and rubropunctamin. Keywords:Monascus purpureus, pigment, angkak, Preparative TLC, LC-MS.
EVALUASI SEDIAAN EMULGEL ANTI JERAWAT TEA TREE (Melaleuca alternifolia) OIL DENGAN MENGGUNAKAN HPMC SEBAGAI GELLING AGENT Nurdianti, Lusi
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Tea tree (Melaleuca alternifolia) oil memiliki terpinen-4-ol yang berfungsi sebagai antibakteri dan anti jamur yang memiliki potensi efektivitas mengobati jerawat. Penelitian ini bertujuan untuk mengetahui formulasi pembuatan sediaan dan evaluasi sediaan emugel Tea tree (Melaleuca alternifolia) oil dengan menggunakan Hidroxy propyl methyl cellulose (HPMC) sebagai gelling agent.Untuk memperoleh sediaan emulgel yang memiliki stabilitas baik maka dilakukan serangkaian tahapan penelitian mulai dari pengumpulan bahan baku, formulasi dan evaluasi sediaan emulgel Tea tre oil. Formulasi yang dibuat terdiri dari tiga formula yaitu F1, F2 dan F3 dengan variasi HPMC sebagai gelling agent. Evaluasi yang dilakukan adalah uji organoleptik, pH, homogenitas, daya sebar, viskositas, Cycling test dan uji hedonik. Analisis data hasil uji viskositas dan uji hedonik diolah dengan penjabaran deskriptif. Hasil uji hedonik menunjukan bahwa emulgel anti jerawat tea tree oil dapat diterima oleh responden. Kata kunci : emulgel, Melaleuca alternifolia, HPMC
IDENTIFIKASI TARGET RESEPTOR SENYAWA 10,11-DIHIDROERISODIN SEBAGAI KANDIDAT ANTIKANKER SECARA IN SILICO Endah, Srie Rezeki Nur
Journal of Pharmacopolium Vol 1, No 1 (2018)
Publisher : STIKes Bakti Tunas Husada

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Abstract

Cancer is one of the most feared diseases and is considered the leading cause of death worldwide. Generally, cancer drugs are synthetic drugs with relatively more expensive prices and have harmful side effects, so many people turn to traditional medicine, for example by utilizing herbal medicine. Erythrina poeppigiana is one of the plants that can be used as a medicinal plant containing 10.11-dihidroerisodin compounds that are useful anticancer etnofarmakologi. The purpose of this study was to identify the target of 10,11 dihydroerisodin receptor compound as an insertiico anticancer candidate. The pure isolate was then tested physicochemically MS, UV-Vis, IR, 13C-NMR, 1H-NMR, to obtain the structure of 10.11-dihydroerisodin alkaloid compound which then to target receptors in silico. From the results of the study it was found that 10.11-dihydroerisodin compound can work on the Serine / threonine-protein kinase Chk1 receptor that serves as an anti-cancer candidate. Keywords : 10,11-dihidroerisodin, anti-cancer, target receptors

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