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Laila Susanti
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INDONESIA
JFL : Jurnal Farmasi Lampung
Published by Universitas Tulang Bawang
ISSN : 23552506     EISSN : 25984896     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
The focus of JFL is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences, natural medicine and clinic community. The scope of the journal is Pharmaceutical sciences, its research and its application.
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Articles 7 Documents
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Search results for , issue "Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung" : 7 Documents clear
FRAKSI ETANOL DAUN LIDAH BUAYA (Aloe vera L.) SEBAGAI ANALGETIKA TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Mashuri Yusuf
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.146

Abstract

Daun lidah buaya (Aloe vera L.) merupakan tanaman obat yang tumbuh subur di Indonesia. Salah satu kandungan utama daun lidah buaya (Aloe vera L.) adalah flavonoid yang memberikan berbagai macam aktivitas farmakologi salah satunya sebagai analgetika. Penelitian ini bertujuan untuk menguji efek analgetika fraksi etanol daun lidah buaya (Aloe vera L.) terhadap tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi secara termik. Hewan uji yang digunakan adalah 25 ekor tikus putih jantan yang dibagi ke dalam 5 kelompok, masing-masing terdiri dari 5 ekor tikus putih jantan. Kelompok 1 diberikan2 ml suspensi CMC 0,5%, kelompok 2 diberikan2 ml suspensi asam mefenamat, sedangkan kelompok 3, 4 dan 5 masing-masing diberikan fraksi etanol daun lidah buaya dengan dosis 6,37 mg/Kg BB, 12,74 mg/kg BB, 25,4 mg/kg BB. Pengujian efek analgetika dilakukan dengan cara memberikan rangsangan nyeri pada hewan uji menggunakan rangsangan panas pada suhu 65˚C. Respon tikus putih jantan yang diamati yaitu gerakan menjilat kaki dan atau melompat. Pengamatan dilakukan selama 1 menit sebelum pemberian zat uji kemudian berturut-turut pada menit ke-30 setelah pemberian bahan uji sampai menit ke-120. Data yang diperoleh dianalisa dengan menggunakan uji anova dan dilanjutkan uji Duncan. Hasil analisa uji anova menunjukkan rata-rata respon tikus putih jantan pada kelompok dosis III tidak berbeda secara bermakna dengan kelompok kontrol positif. Hasil penelitian menunjukkan bahwa fraksi etanol daun lidah buaya memiliki efek analgetika terhadap tikus putih jantan galur wistar. Dosis III 25,4 mg/Kg BB menunjukkan penurunan analgetika lebih besar dibanding dosis I dan II. Kata kunci : Analgetika, daun lidah buaya, tikus putih jantan
FRAKSI ETANOL, KLOROFORM, DAN N-HEKSAN BUNGA KAMBOJA PUTIH (Plumeria acuminata L.) SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli dan Staphylococcus aureus DENGANBIOAUTOGRAFI Yuli Wahyu Trimulyani
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.147

Abstract

Frangipani flowers (Plumeria acuminata L.) Flower is one of the plants that has antibacterial properties. Compounds that act as antibacterial are flavonoids and tannins. The purpose of this study was to prove the antibacterial activity of ethanol, chloroform, and n-hexane fractions of Frangipani flowers (Plumeria acuminata L.) flower as antibacterial against E. coli and S. aureus with Bioautography.The process of extracting plumeria acuminata L. flowers was carried out by maceration method using 70% ethanol. The extract was continued with the fractionation process with ethanol, n-hexane and chloroform solvents. Antibacterial activity testing using the well method with concentrations of 20%, 40%, 60%, 80%, 100%, positive chloramphenicol control, and negative aquadest control. The compound content test used the Thin Layer Chromatography (TLC) method with the mobile phase of chloroform: methanol: water (2:5:3) (v/v).Bioautography test using the contact method, namely the elution TLC plate, was placed on the NA medium containing a bacterial suspension for 3 hours. The biggest antibacterial test results of ethanol fraction of plumeria acuminata L. flowers were at a concentration of 100% with a diameter of inhibition zone of 13.55 mm in E. coli while 14.15 mm S. aureus. The results of TLC showed the presence of flavonoids with a price of Rf 0.70 and tannin at a price of Rf 0.68. Bioautography results showed a inhibition zone with a price of Rf 0.70 in E. coli and S. aureus which are flavonoid compounds. Based on the results of the research that has been done it can be concluded that the ethanol fraction of white frangipani flowers has antibacterial activity against E.coli and S. aureus, while the chloroform fraction and n-hexane fraction do not have antibacterial activity. The active compounds that act as antibacterial are flavonoids and tannin, but the ones that provide antibacterial effects are flavonoids with an Rf value of 0.70. Keywords: Bioautography,Escherichiacoli, Frangipani flowers, Staphylococcusaureus, TLC
EKSTRAK ETIL ASETAT DAUN JAMBU BIJI MERAH (PSIDIUM GUAJAVA L.) SEBAGAI ANTIOKSIDAN SECARA IN VITRO Jihan Farah
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1503.237 KB) | DOI: 10.37090/jfl.v8i2.143

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak daun jambu biji (Psidium gujava L.). Ekstrak daun jambu biji (Psidium gujava L.) diekstraksi secara maserasi dengan pelarut etil asetat. Uji aktivitas antioksidan diuji dengan metode DPPH (2,2-Diphenyl-1-Picrylhidrazil) dengan kuersetin sebagai kontrol positif. Antioksidan ditentukan dengan menguji terhadap radikal bebas DPPH dengan mengukur absorbansi DPPH pada panjang gelombang 516 nm. Hasil aktivitas antioksidan menunjukkan bahwa nilai IC50 pada etil asetat adalah 37,39 ppm (sangat kuat). dan kuersetin sebesar 0,562 ppm (sangat kuat). Berdasarkan hasil analisis antioksidan diperoleh bahwa ekstrak etil asetat daun jambu biji memiliki aktivitas antioksidan sangat kuat. Kata kunci: Jambu biji, antioksidan, DPPH, kuersetin.
PENGARUH FRAKSI AIR BIJI KABAU (Archidendron buballinum (Jack.) I.C.Nielsen) TERHADAP KADAR GULA DARAH MENCIT JANTAN YANG DIINDUKSI ALOKSAN Triyandi Ramadhan
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.148

Abstract

Biji kabau (Archidendron buballinum (Jack.) I.C.Nielsen) secara empiris dimanfaatkan oleh masyarakat dibeberapa daerah di Indonesia sebagai obat tradisional seperti obat sakit perut dan penurun demam. Penelitian ini bertujuan untuk mengamati aktivitas fraksi air biji kabau (Archidendron buballinum (Jack.) I.C.Nielsen) terhadap kadar gula darah mencit jantan yang diinduksi aloksan. Biji kabau diekstraksi dengan cara maserasi menggunakan pelarut etanol 70 % dan difraksinasi menggunakan pelarut kloform dan n-heksan. Uji antidiabetes dilakukan terhadap mencit jantan yang diinduksi aloksan secara intraperitonial dengan dosis 3,36 mg/20 g BB selama 7 hari. Sebanyak 20 ekor mencit dikelompokkan menjadi 5 kelompok. Kelompok I sebagai kontrol negatif diberi aquadest dan kelompok II sebagai kontrol positif diberi Glibenklamid dosis 0,013 mg/20 g BB, Kelompok III, IV dan V sebagai kelompok perlakuan diberi fraksi dengan dosis 1,71 mg/20 g BB, 3,43 mg/20 g BB dan 6,86 mg/20 g BB, kelima kelompok diberi perlakuan secara oral sebanyak 1 kali sehari selama 4 hari. Penurunan kadar gula darah diukur dan diamati pada hari ke-8 dan-11, kemudian pada hari ke-12 dianalisis dengan metode Kruskal-Wallis Test. Hasil karakteristik simplisia terhadap kadar air 0,24 %, kadar abu 3,33 % dan kadar abu tidak larut asam 2,3 %. Uji fitokimia fraksi air biji kabau menunjukkan adanya senyawa saponin, alkaloid dan tanin. Hasil analisis menunjukkan kelompok I, II dan III berbeda nyata terhadap kontrol negatif dan berefek sama terhadap kontrol positif dalam menurunkan kadar gula darah mencit jantan diabetes yang diinduksi aloksan. Dari ketiga dosis tersebut dosis 6,86 mg/20 g BB menunjukkan penurunan yang paling baik, namun dosis 1,71 mg/20 g BB tidak berbeda nyata secara statistik terhadap glibenklamid, sedangkan dosis 3,43 mg/20 g BB dan dosis 6,86 mg/20 g BB berbeda nyata secara statistik terhadap glibenklamid. Berdasarkan hasil pengujian dapat disimpulkan bahwa fraksi air biji kabau berpengaruh terhadap penurunan kadar gula darah mencit jantan diabetes yang diinduksi aloksan. Kata kunci: Archidendron buballinum, Diabetes, Fraksi, Kabau
DECREASE IN FREE FATTY ACID CONTENT AND COLOR AT USED COOKING OIL WITH ACTIVATED CARBON OF REEDS (Imperata cylindrica L. Raeusch) Samsuar Samsuar
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.144

Abstract

Cooking oil is one of the foods that are needed by the community in daily life. The use of cooking oil continuously at high temperatures, produces cooking oil that is no longer feasible to use. Therefore, it’s necessary to purify used cooking oil so that it can be reused for non-foood purposes such as making soap or biodiesel fuel. This purification process is utilie the activated carbon of reeds (Imperata cylindrica L. Raeusch) as an adsorbent to reduce the levels of free fatty acids and colors in used cooking oil. Free fatty acid content test using acid base titration method and color change using Uv-Vis spectrofotometry method. This study aims to determine the optimum concentration of reeds activated carbon as an adsorbent in reducing the levels of free fatty acids and colors in used cooking oil, which consists of the concentration of reeds activated carbon which is a consentration of 2,5; 5; 7,5; 10; dan 12,5%. The results of variance analysis showed the optimum concentration of reeds activated carbon to reduce the levels of free fatty acids and colors absorbance in used cooking oil at a concentration of 7,5%. The percentage of decreasing levels of free fatty acids gorengan and pecel lele are 78.57% and 78.85%. Decrease in absorbance of gorengan color from 1,792% to 0,384% and the pecel lele color absorbance from 2,521 to 0,515. Keywords : Activated Carbon,Color, Free Fatty Acid, Reeds, and Used Cooking Oil.
THE RELATION BETWEEN KNOWLEDGE AND ATTITUDE TOWARD BEHAVIOR OF ANTIBIOTIC USAGE ON SOCIETY IN TALANG JAWA HEALTH CENTER OF SOUTH LAMPUNG AUGUST PERIOD 2019 Lilik Koernia Wahidah
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.149

Abstract

In developing countries, many antibiotics are used without a doctor's prescription, causing someone to use antibiotics incorrectly. Lack of knowledge about antibiotics is a major factor that triggers an increase in the rate of bacterial resistance to antibiotics. Knowledge and attitude become one of the social cognitive factors that influence antibiotic use behavior.This study aims to determine the relationship of knowladge and attitudes toward of antibiotic usage behavior in community of Talang jawa public health centre. The research is an observasional analytic research using cross sectional study design. sampling using non-probability sampling methode with type purposive sampling and instruments in the form of questionnaires. The data analysis was based univariate and bivariate analysis eqipped with chi square. The study was conducted on 100 community respondents in the Talang Jawa Health Center. The results showed respondents with good knowledge (25%), enough (27%) and less (48%). Respondents with positive attitudes (64%) and negative attitudes (35%). Respondents with positive behavior (43%) and negative behavior (57%). Chi square test result showed that there was a significant relationship between knowladge and antibiotic use behavior (p= 0,000) and there was a significant relationship between attitude and antibiotic use behavior (p= 0,000). This study has a meaningful relationship between and attitudes with antibiotic use behavior in Talang Jawa Health Center. Keywords: Antibiotics,Knowledge, Attitudes, Behavior
Ethanol Fraction of Corn Silk (Zea mays L.) to Decrease Uric Acid Levels in Male White Mice Laila Susanti
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.145

Abstract

Corn silk (Zea mayz L.) were empirically used by the community in some regions as traditional remedies for hypertension,kidney stones,diabetes mellitus, urinary tractinfections and gout. This study aimed to determine the effect of corn silk ethanol fraction on decrease uric acid levels in male white mice.corn silk were extracted by macerate used 70% ethanol for 4 days.Urin acid test was performed on male mice induced by beef liver for 7 days.25 mice were grouped into 5 groups, groups dose I, II and III weregiven a fraction at a dose of 27.5 mg / bwBB, 55 mg / bwBB and 110 mg / bwBB, control given Na.CMC 0.5% and as positive controls were given allopurinol dose of 13 mg / bwBB. The five groups were treated orally 1 time a day for 7 days. Decreased uric acid levels were measured and observed on days 7 using an acid (easy touch). The results of ANOVA statistical analysis showed that negative controls gave a significant difference with positive controls, dose I, II and III because the sig value was

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