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Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 222 Documents
Toksisitas Akut Ekstrak Sembukan (Paederia scandens (Lour.) Merr. pada Mencit (Mus musculus L.) Galur Swiss Ida Fitriana; Agustina Dwi Wijayanti; Puspa Wikan Sari
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.444 KB) | DOI: 10.31001/jfi.v13i1.4

Abstract

Sembukan (Paederia scandens (Lour.) Merr. belonging to Rubiaceae family that grows wild, sometimes was used as animal feed and traditional herbal medicine. Therefore, it is important to determine the safety of sembukan when consumed or used as a herbal medicine. This study aimed to determine the potential acute toxicity of the extract of sembukan using Organisation for Economic Co-operation and Development (OECD) 423 method which measured the clinical symptoms caused, and histopathologic of liver, kidney, and heart disease due to oral administration. Fifteen female Swiss Webster mouse weighing 25-35 gram used in this study. The procedure of this study followed the OECD method 423 using an initial dose of 300 mg/kg BW sembukan extract. Histopathological examination was done hematoxylin-eosin staining. The observation of histopathology and clinical toxicity symptoms were analyzed descriptively, while data changes on body weight of animals, organ weights, and the amount of feed intake was analyzed statistically. The results showed sembukan extract is safe to use. According to the Globally Harmonized System Classification (GHS), the potential for acute oral toxicity of the extract sembukan included in category 5 (not clarified) with LD50 cut-off > 2000-5000 mg/kg BW. Giving the test preparation did not affect body weight, feed intake, clinical symptoms of toxicity,and there was no pathological changes in the heart organ.
Induksi Sintesa Kurkuminoid Dalam Kalus Temulawak (Curcuma Xanthorriza, Roxb) Akibat Pengaruh Hormon 2,4-D Dan Fenilalanin Pada Media Kultur Yudi Rinanto
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.385 KB) | DOI: 10.31001/jfi.v6i1.8

Abstract

The addition of precursor into in vitro Murashige Skoog (MS) media culture expected to be able improve curcuminoid synthesis within the callus. Phenylalanine is precursor in curcuminoid synthesis. 2,4-D hormone is also added into media culture to induce callus formation. The concentration of 2,4-D hormone and phenylalanine is 0, 2 and 4 ppm, respectively. The qualitative analysis was done with color reaction and Thin Layer Chromatography (TLC) with gel silicon GF254 as stationary phase and chloroform : ethanol 96%: glacial acetic acid (94:5:1) as movement phase and detected by the visible ligh. The quantitative analysis was done by measuring the spot area in the TLC chromatogram with TLC scanner, and then was calculated using standart curcumin curve. Base on the experiment indicates 2,4-D Hormone with 4 ppm result the fastest time callus induction. Curcuminoid content is higher in rhizome compared in callus. The combination of 2,4-D hormone and phenylalanine yield the higher curcumin content than desmetoxi-curcumin for each treatment combination. The highest curcumin content is produced by 2,4-D hormone and phenylalanine combination with 4 ppm concentration that is 0,39 %. Meanwhile the highest desmetoxi-curcumin is produced by 2,4-D hormone and phenylalanine combination with 4 and 2 ppm concentration, respectively, that is 0,18 %. 2,4-D hormone and phenylalanine affects more significantly in curcumin synthesis rather than desmetoxi-curcumin.
Pengaruh Magnesium Stearat, Talk atau Kombinasinya Terhadap Waktu Hancur dan Disolusi Tablet Prednison Pada Campuran Interaktifnya Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.098 KB) | DOI: 10.31001/jfi.v6i1.9

Abstract

Interactive mixtures give advantages for the mixtures containing low dose drug such as prednisone as it guarantee homogeneity, stability and increase the dissolution of prednisone. Flowability and compactibility of the interactive mixtures are relatively good, it can be directly compressed to produce tablet. The addition of lubricant / glidant of Mg stearat , talc or their mixture as the cohesive materials to the prednisone-granule interactive mixtures produce prednisone- granule-lubricant/ glidant which affect the tablet properties such as disintegration time and release of the drug. Based on these matter, a study was done to examine effect of Mg stearat, talc or their mixtures to the disintegration time and dissolution of prednisone interactive mixtures tablet. For the investigation of these effects, experiments were done using optimization approach based on simplex lattice design with Mg stearate and talc as the independent variable. The experiments data were implemented into the equation relation to the simplex lattice design : Y= a(A) + b (B) + ab (A) (B). Based on the coefficient value of the disintegration time and drug dissolution equations, profiles are made, lubricant/glidant effects on the disintegration time and drug dissolution can be analyzed. Magnesium stearate cause prednisone interactive mixtures disintegration time tablet are more longer than talc, although the affect interaction is relativity more little. Magnesium stearate compared with talc gives C30 value and DE-60, although the interaction gives affect relativity more little.
OPTIMASI CAMPURAN AVICEL PH 101 DAN PATI JAGUNG DALAM PEMBUATAN TABLET EKSTRAK DAUN MIMBA (Azadirachta indica A. Juss) SECARA Simplex Lattice Design Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.098 KB) | DOI: 10.31001/jfi.v6i1.10

Abstract

Avicel PH 101 is an excipient in tablet making that can be used as diluent, binder, lubricant, and disintegrator. Avicel is not economically an advantage so that it needs to be combined with cheaper materials. Combination of Avicel PH 101 with corn starch is able to accelerate the disintegration time of the tablet. Mimba (Azadirachta indica A. Juss) leave is a traditional medicine that is used as anti-inflammation. The study was to find out the optimum proportion of Avicel PH 101 and corn starch mixture in tablet making of mimba leaves extract by simplex lattice design method. The extract of mimba leaves was obtained by maceration of mimba leaves powder with ethanol 70%. The obtained extract was evaporated until a thick extract was obtained. Tablet formulation was based on SLD method with excipients of Avicel PH 101 (A) and corn starch (B) i.e. F1 (100% A), F2 ( 50% A : 50% B), F3 (100% B). The tablets of mimba leaves extract were made by wet granulation. The equation was used to make tablets with total respond of the most optimum granules physical properties. The data of the physical properties of granules from optimum formula as calculation result based on SLD equation with the experiment result was analyzed using T-test. Tablets from optimum formula were physically tested including weight uniformity, hardness, friability and disintegration time. The result of theexperiment indicated that the mixture of 90% Avicel PH 101 – 10% corn starch produced an optimum result in granules physical properties and the obtained tablets of mimba leaves extract fulfilled tablet physical property test.
ANALISIS FERRO SULFAT DARI LIMBAH BESI Soebiyanto Soebiyanto
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.85 KB) | DOI: 10.31001/jfi.v6i1.11

Abstract

Iron Deficieny Anemia (IDA) is one of msjor micronutrient deficiency in Indonesia. IDA is that Indonesian people suffered from 100 million of population. One of the correct ways IDA problems is suplementation with ferrous sulfate. To can use raw material farmacy, it must fulfilquality standart in Indonesia Pharmacope Edition IV.The aims of research is producing, purification and analyses ferrous sulfate from iron waste. Producing of ferrous sulfate is reacting iron waste with acid sulfuric 25% during 2 days. Separated and purification crystal with recrystalyzation then determination with SEM-EDS analysis. The obtain of research shows ferrous sulfate content Fe 54,46%, O 33,55% and S 11,99%. These results show that ferrous sulfate from iron waste fulfil quality standart in Indonesia Pharmacope.
UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK DAUN MONDOKAKI (Tabernaemontana divaricata, R.Br.) PADA TIKUS PUTIH JANTAN Jason Merari Peranginangin
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.962 KB) | DOI: 10.31001/jfi.v6i1.12

Abstract

Mondokaki plant (Tabernaemontana divaricata, R.Br.) is a traditional medicine used in medicating high blood pressure, pharyngitis, conjunctivitis, mastitis, mad dog bite, antitusissive, anti-inflammatoty and sprain. The aim of the research was to know the anti-inflammatory effect of mondokaki leaves ethanolic extract on male shite rat. Mondokaki leaves were extracted using ethanol 70% by maceration method. The extract was tested to each group of the rat with doses of 3.75 mg/200 g bw, 7.5 mg/200 g bw, 15 mg/200 g bw. The negative control group was given CMC 0.5% solution and the positive control group was given sodium diclofenac as antiinflammatory agent. The compounds were all given orally one hour before the rat plantar was injected with carragenin 1% to make edema. The anti-inflammatory effect was observed from the ability to reduce edema volume at one hour interval for five hours. One way analysis of varian at 95% confidence was done to know the difference in each treatment and LSD test was done to know the difference between the treatment groups. The result of the research showed that ethanolic extract of 15 mg/200 g bw dose did not significantly different compared with the positive control. It was indicated that ethanolic extract of 15% mg/200 g bw dose had anti-inflammatory effect by reducing edema volume of male white rat in proportion with the positive control.
Analisa Pengaruh Adanya Instalasi Pengolahan Air Limbah terhadap Kadar Chrom pada Limbah Batik Pabrik di Kabupaten Pekalongan Tri Minarsih
Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2737.926 KB) | DOI: 10.31001/jfi.v6i3.13

Abstract

Waste water originating from batik production is one potential source of water pollution. This is because of batik production of waste water containing organic compounds are quite high, contain chemical compounds that contain dangerous and pathogenic microorganisms that can cause disease. Waste is a heavy metal chromium Cr (VI), which is one type of hazardous waste, can be derived from batik industry, metal plating (electroplating), and tannery (leather tanning). The concentration of chromium was done in the waste analysis before and after experiencing batik processing and industrial wastewater in a river after passing around pabrik. Penetapan chromium content visible spectrophotometer method using Difenilkarbazida. At the preliminary examination that pH of treated wastewater does not meet the requirements of waste water quality standard is five, and also chromium levels that still exceed the Central Java Provincial Regulation No. 10 Year 2004 water quality standards and batik textile industrial waste that is 10.1181 mg / L and after passing through two kilometers of the river flow is still too high at 7.6277 mg / L.
Natrium Kromolin, Obat Penghambat Degranulasi Sel Mast, Lebih Efektif terhadap Sel Mast Jaringan Ikat Dibanding Sel Mast Mukosa Agung Endro Nugroho
Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2800.66 KB) | DOI: 10.31001/jfi.v6i3.14

Abstract

Cromolyn sodium is an antiallergy drug that acts by inhibiting mast cells degranulation responsible for the release of histamine, a mediator for this disease. Moreover, cromolyn sodium is used as a first line drug in asthmatic therapy. However, cromolyn sodium did not always show the inhibition effects on histamine release from mast cells in all allergy experiment models. The aim of present study was to reconfirm the effect of cromolyn sodium on the histamine release from RBL-2H3 cells line induced by DNP24-BSA as an antigen, and compare to it’s positive effect on active cutaneous anaphylaxis model induced by ovalbumin as an antigen. The results showed that cromolyn sodium did not inhibit the histamine release from RBL-2H3 cells line induced by DNP24-BSA significantly, but inhibited active cutaneous anaphylactic reaction induced by ovalbumin significantly.
Aktivitas Antidiabetes Jamur Lingzhi (Ganoderma lucidum) pada Tikus Putih Jantan Dwi Ningsih; Endang Sri Rejeki; Dewi Ekowati
Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3579.645 KB) | DOI: 10.31001/jfi.v6i3.15

Abstract

Diabetes mellitus is one of the degenerative diseases of concern to government and society, because the incidence of sufferers is increasing from year to year. Lingzhi (Ganoderma lucidum) mushroom is a traditional medicinal plant which one of the benefits to treat diabetes mellitus. This study aimed to identify and seek the most effective dose of lingzhi mushroom extract to decrease blood glucose levels in white male rats of wistar strain. Lingzhi mushroom extracted by maceration with ethanol 96% and infuse it with aquadest. The ethanol extract was tested on each group of test animals with a dose of 1.18 mg/200 g BW; 2:36 mg/200 g BW and 4.71 mg/200 g BW. Negative control group given CMC 1% and the positive control group was given glibenclamide (90 mg/200gBB). Aqueous extract obtained was tested after the optimal dose of ethanol extract. Antidiabetic effect is obtained by measuring blood glucose levels for 2-week with intervals measure every week, then performed statistical tests with two-way analysis of variance with a level of 95% followed Dunnett test. The results showed that the lingzhi mushroom has antidiabetic activity in male rats. Ethanol 96% extract of lingzhi mushroom (1.18 mg/200 g BW) most effectively to decrease blood glucose. Water extract at a dose equivalent to 1.18 mg/200gBB have equally strong effects with ethanol extracts.
Aktivitas Antibakteri Ekstrak n-Heksan, Etil Asetat, dan Etanol 70% Daun Binahong (Anredera cordifolia (Ten.) Steen) terhadap Pseudomonas aeruginosa ATCC 27853 Dyah Susilowati; Putri Manggara Mitha
Jurnal Farmasi Indonesia Vol 6 No 3 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4177.71 KB) | DOI: 10.31001/jfi.v6i3.16

Abstract

Binahong leaf (Anredera cordifolia (Ten.) Steen) are type of crops which good to heal some kinds of diseases. Binahong leaf contains the saponin, flavonoid, and polifenol. This research aim to know the antibacterial activity of n-heksan extracts, ethyl acetate and etanol 70 % from Binahong leaf that most effective to Pseudomonas aeruginosa ATCC 27853. Binahong leaf powder high rise soxhleted by n-heksan, ethyl acetate, and etanol 70 % solvent. Jell extracts of n-heksan, ethyl oacetate and etanol 70 % extract obtained were tested of antibacterial activity by 2 methods and made with concentration 100 % (b/v); 50 % (b/v); 25 % (b/v); 12,5 % (b/v); 6, 25 % (b/v); 3,125 % (b/v); 1,56 % (b/v); 0,78 % (b/v); 0,39 % (b/v); and 0,195 % (b/v) to antibacterial activity test by dilution method. Diffusion method conducted by made of well that have diameter 9 mm, then dripped with n-heksan extracts, ethyl acetate and etanol 70 % with concentration 25 %; 50 %; 75 %; 100 %; and blanco each counted 40 µl, then measured by its resistance diameter. Experiment result of antibacterial activity test Pseudomonas aeruginosa ATCC 27853, ethyl acetate and etanol 70 % extracts has KBM 50 % (b/v) dan 25 % (b/v), while n-heksan extracts do not give KBM. Research result of diffusion method give the resistance area by mean of acetate ethyl extracts 8,33 mm (75 %); 11,67 mm (100 %) and for the etanol 70 % extracts 9,67 mm (50 %); 12,67 mm (75 %); 15,33 mm (100 %) while for the of n-heksan extracts do not give the resistance area. So can be concluded that etanol 70 % extracts more effective as antibacterial to Pseudomonas aeruginosa ATCC 27853 than n-heksan and ethyl acetateextracts.

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