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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 10 Documents
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Search results for , issue "Vol 10, No 1 (2018)" : 10 Documents clear
AMBARAN FUNGSI HATI PASIEN SKIZOFRENIA YANG MENGKONSUMSI RISPERIDONE DENGAN LORAZEPAM Kurniati, Tripeni; Darmawan, Endang; Anggriani, Hesti
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.579

Abstract

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomo’s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
Analisis Selektivitas Senyawa Turunan Diosmetin Sebagai Antioksidan Baru dengan menggunakan Metode MolecularDocking Martati, Titiek; Mumpuni, Esti; Mulatsari, Esti; Maryanto, Kenny
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.581

Abstract

Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F).
ANALISIS KERASIONALAN PENGOBATAN PASIEN SKIZOFRENIA DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH KOTA X PADA JANUARI-JUNI 2015 Nur’aini, Nur’aini; Rahayu, Mustika; Wijayanti, Rahayu
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.582

Abstract

Schizophrenia is a severe mental disorder with signs and symptoms which are diverse, both in degree and kind, and is often characterized with a chronic and recurrent trips. According to research in the various countries, the prevelance in the general population ranges from 1% - 3%. Antipsychotic drugs are considered as first-line therapy in schizophrenia. This study aimed to analyze the rationalization of the treatment of schizophrenia at pharmacy Plant of General Hospital X in January-June, 2015. Based on 8 T, namely the right diagnosis, precise indications of the disease, proper drug selection, right dosage, right route of administration, proper interval time of administration, appropriate duration of administration, wary of side effects on the population by the method of retrospective or data that are past which were then analyzed using Microsoft excel and are presented in tables and diagrams. The result of the data were taken from the installation of the patient medical record with the number 60. The results showed that of 60 patients 52 or 86.7% of them were not rational and 8 patients, or 13.3% rational. Proper diagnosis, appropriate treatment regimens, the exact time interval of drug administration, appropriate duration of administration have the same percentage that the level of rationalization of the 60 (100%) patients, the exact indication of the disease by 48 (80%) patients was not rational, and 12 (20 %) patients rational, be aware of drug side effects 50 (83.3%) patients who were not rational, and 10 (16.6%) patients who had a rational, appropriate doses of 58 (96.7%) patients and 2 (3,3%) irrational patients, the proper selection of drugs 14 (23.3%) patients that were not rational, and 46 (76.67%) rational
SINTESIS ANALOG UK-3A : 6-HIDROKSI-N-FENILNIKOTINAMIDA DAN 6-HIDROKSI-N- FENILPIKOLINAMIDA DAN UJI SITOTOKSISITAS SECARA IN VITRO TERHADAPSEL KANKER MURINE LEUKEMIA P388 Febriyanti, Lilis; Hanafi, Muhammad; Hayun, Hayun
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.583

Abstract

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 µg/mL and 63 µg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 µg/mL.
ANALISIS KERASIONALAN PENGOBATAN PASIEN SKIZOFRENIA DI INSTALASI FARMASI RUMAH SAKIT UMUM DAERAH KOTA X PADA JANUARI-JUNI 2015 Nur’aini, Nur’aini; Rahayu, Mustika; Wijayanti, Rahayu
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1037.933 KB) | DOI: 10.35617/jfi.v10i1.582

Abstract

Schizophrenia is a severe mental disorder with signs and symptoms which are diverse, both in degree and kind, and is often characterized with a chronic and recurrent trips. According to research in the various countries, the prevelance in the general population ranges from 1% - 3%. Antipsychotic drugs are considered as first-line therapy in schizophrenia. This study aimed to analyze the rationalization of the treatment of schizophrenia at pharmacy Plant of General Hospital X in January-June, 2015. Based on 8 T, namely the right diagnosis, precise indications of the disease, proper drug selection, right dosage, right route of administration, proper interval time of administration, appropriate duration of administration, wary of side effects on the population by the method of retrospective or data that are past which were then analyzed using Microsoft excel and are presented in tables and diagrams. The result of the data were taken from the installation of the patient medical record with the number 60. The results showed that of 60 patients 52 or 86.7% of them were not rational and 8 patients, or 13.3% rational. Proper diagnosis, appropriate treatment regimens, the exact time interval of drug administration, appropriate duration of administration have the same percentage that the level of rationalization of the 60 (100%) patients, the exact indication of the disease by 48 (80%) patients was not rational, and 12 (20 %) patients rational, be aware of drug side effects 50 (83.3%) patients who were not rational, and 10 (16.6%) patients who had a rational, appropriate doses of 58 (96.7%) patients and 2 (3,3%) irrational patients, the proper selection of drugs 14 (23.3%) patients that were not rational, and 46 (76.67%) rational
SINTESIS ANALOG UK-3A : 6-HIDROKSI-N-FENILNIKOTINAMIDA DAN 6-HIDROKSI-N- FENILPIKOLINAMIDA DAN UJI SITOTOKSISITAS SECARA IN VITRO TERHADAPSEL KANKER MURINE LEUKEMIA P388 Febriyanti, Lilis; Hanafi, Muhammad; Hayun, Hayun
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1582.11 KB) | DOI: 10.35617/jfi.v10i1.583

Abstract

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 µg/mL and 63 µg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 µg/mL.
AMBARAN FUNGSI HATI PASIEN SKIZOFRENIA YANG MENGKONSUMSI RISPERIDONE DENGAN LORAZEPAM Kurniati, Tripeni; Darmawan, Endang; Anggriani, Hesti
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1329.822 KB) | DOI: 10.35617/jfi.v10i1.579

Abstract

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomo’s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2110.257 KB) | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
Analisis Selektivitas Senyawa Turunan Diosmetin Sebagai Antioksidan Baru dengan menggunakan Metode MolecularDocking Martati, Titiek; Mumpuni, Esti; Mulatsari, Esti; Maryanto, Kenny
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1421.953 KB) | DOI: 10.35617/jfi.v10i1.581

Abstract

Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F).

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