ISM (Intisari Sains Medis) : Jurnal Kedokteran
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
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<![CDATA[Mekanisme repigmentasi dan peran melanocyte stem cell folikel rambut pada vitiligo ]]>
<![CDATA[IGAA Praharsini]]>;
<![CDATA[Nyoman Suryawati]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/ism.v9i1.143
<![CDATA[Vitiligo merupakan kelainan pigmen yang karakteristik dengan adanya destruksi progresifmelanosit matur di epidermis akibat respon autoimun. Terapi vitiligo bertujuan memulihkanpigmentasi yaitu mengganti melanosit yang rusak dengan melanosit yang baru yang berasal darimelanocyte Stem Cell unit folikel rambut. Melanosit folikel rambut ini berperan penting dalamrepigmentasi lesi vitiligo. Pola repigmentasi pada vitiligo meliputi repigmentasi perifolikuler,repigmentasi difus, repigmentasi marginal, kombinasi, dan medium spottled. Mekanisme repigmentasimelalui melanosit berasal dari tepi lesi vitiligo, bulge, selubung akar luar rambut dan dermal sertaepidermal precursors melanocyte yang persisten terletak di tengah lesi vitiligo, yang bermigrasisecara sentrifugal sehingga menyebabkan pigmentasi difus. Proliferasi dan diferensiasi melanosit inijuga tergantung pada growth factor, gen, faktor transkripsi dan jalur signaling pada prosesmelanogenesis. Seiring dengan perkembangan biologi molekuler, penelitian-penelitian saat iniberfokus pada Melanocyte Stem Cell folikel rambut dan terus dikembangkan sebagai terapi vitiligodi masa depan.]]>
<![CDATA[Korelasi antara kadar testosteron total dengan trans epidermal water loss (TEWL) pada pria late onset hypogonadism ]]>
<![CDATA[Daniel Widiyanto]]>;
<![CDATA[Reny I’tishom]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/ism.v9i1.144
<![CDATA[Background: Late Onset Hypogonadism (LOH) is a clinical and biochemical condition in the elderly with testosterone levels below the reference value of young and healthy men, accompanied by symptoms of testosterone deficiency. Increased age or aging process is one of the factors causing sebaceous gland function decreased both regarding quantity and regarding quality associated with the function of lipid barrier. Decreased sebum gland function can be seen from several parameters, one of which is the increase of Trans Epidermal Water Loss (TEWL). Methods: This study was an observational analytic study with cross-sectional design to determine the relationship between total testosterone and TEWL in LOH men. This research was conducted in Outpatient Unit Andrology of dr. Soetomo from May 2017 to July 2017. 16 samples of elderly male patients (≥60 years) were selected using the consecutive sampling technique who met the inclusion and exclusion criteria. Performed total testosterone test and TEWL level examination by using Tewameter to the research sample. Interpretation of results adjusted to Research and Development Department, Courage & Khazaka Electronics GmbH, Koln, Germany. Results: The Total testosterone levels of the patient were ranged from 146.11 - 575.10 ng/dL with a mean of 351.67 ng/dL and standard deviation of 116.34. The TEWL level of the patients was ranged from 17.2 - 50.8 g/jam/m2 with a mean of 31 g/jam/m2 and standard deviation of 9.20. The correlation coefficient value between total testosterone and TEWL was -0.853 with a significance of 0.0001 (p <0.05). Conclusion: There was a significant relationship between total testosterone and TEWL. The association of total testosterone with TEWL is unidirectional. The lower the testosterone level, the higher the TEWL value.]]>
<![CDATA[Profil pasien baru HIV di poliklinik VCT BRSU Tabanan Bali pada tahun 2009 sampai 2017 ]]>
<![CDATA[R Prawira Bayu]]>;
<![CDATA[I Gusti Ngurah Made Budiana Indrawan]]>;
<![CDATA[Ni Nengah Sukarni]]>;
<![CDATA[Made Edwin Sridana]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/ism.v9i1.145
<![CDATA[Background: HIV infection is a disease that currently becomes a global problem. Bali is one of the provinces in Indonesia with very high HIV infection new case. Badan Rumah Sakit Umum (BRSU) Tabanan is one of the leading hospitals in Tabanan. Based on data in Voluntary Counseling and Testing (VCT) clinic in BRSU Tabanan, new diagnosed HIV patients are increasing from year to year, so research about new diagnosed HIV patient profile is needed. This research is a descriptive research. Methods: The research design used in this study is cross-sectional study. Population and sample in this study were all newly diagnosed patients with HIV infection in BRSU Tabanan VCT clinic from 2009 to 2017 with a total of 872 people were obtained by total sampling. Secondary data were then processed statistically using statistical software. Results: From this research obtained that new case is the most in the year 2016 (18,5%). With the most patient in age 30 – 39 years old age group (34,9%), male (60.1%), still in employment (22.4%), still living (93.9%), and predicted risk factor heterosexual (93,7%). When the sample is diagnosed HIV most of the patient in stadium 3 (53,6%), with the most clinical sign is weight loss more than 10% in one month (50,2%), and opportunistic infection Candidiasis (55.6%). Conclusions: In an attempt to reduce spreading of HIV, education about transmitted sexual disease and reproduction health are important, especially in high-risk groups. ]]>
<![CDATA[Gambaran riwayat kejadian diare pada balita dan pelaksanaan PHBS dalam tatanan rumah tangga di Desa Gegelang Kecamatan Manggis tahun 2013 ]]>
<![CDATA[Dewa Agung Istri Sintha Prajnyaswari]]>;
<![CDATA[Wayan Citra Wulan Sucipta Putri]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.147
<![CDATA[Diarrhea is the second leading cause of death in infants. As one of the disease-based environment, the availability of clean water, sanitation and hygiene is one of the key actors in the incidence of diarrhea. As one of the efforts to improve sanitation and hygiene, health center movement Manggis I community health center develops behaviors of live clean and healthy (PHBS) at the family level. The lowest percentage of households classified by PHBS located in the Gegelang Village which amount is 46%. Among the 10 points PHBS, the cause of diarrhea in infants can be sourced history of exclusive breastfeeding, use of unclean water, the habit of not washing hands with soap and clean water, and does not have healthy latrines. This study was a descriptive cross-sectional study involving seventy-five respondents, i.e. mothers with under five children (12-60 months) in Hamlet Gegelang, Kalanganyar, and Pakel, Gegelang Village. Sampling technique is done by using accidental sampling method. Data collection was conducted using a questionnaire. In this research is found only 13 of 75 (17.3%) of respondents said that the children did not have diarrhea in the last 1 year. A total of 53 respondents (70.7%) said that they did not give exclusive breastfeeding to her child. All respondents had access to clean water, but only 32 of 75 (42.7%) of respondents who process a clean water with appropriate way before drunk. Good hand washing habits only depicted in 30 of 75 (40%) of respondents. Latrine ownership were vary from having latrine with standards compliant (38.7%), have latrine but do not fit to standards-compliant (25.3%), and did not have latrine (36.0%). Conclusion of cross-tabulations showed a trend increase in the number history of diarrhea in under five children on the implementation of PHBS that do not fit to health standards.]]>
<![CDATA[Efektifitas tulisan dan gambar peringatan kesehatan pada produk rokok terhadap kesadaran merokok di Kabupaten Badung, Bali-2015 ]]>
<![CDATA[I Nyoman Gede Suyasa]]>;
<![CDATA[Desak Gde Diah Dharma Santhi]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.148
<![CDATA[Starting in June 2014 tobacco products circulating in Indonesia must be accompanied by pictures and written health warnings. Pictorial warnings can raise public awareness about the impact of smoking, and advocates people to stop smoking. The research objective is to analyze changes in the awareness of smokers after the Ministry of Health policy writing and picture health warnings on the pack of cigarettes. This is an observational study with sample of the population of smokers in Badung. The sample size is 100 people. Sampling is using cluster sampling method, the number of clusters as many as 10 clusters and each cluster includes 10 respondents, 10 clusters selected by PPS. Primary data collection techniques and awareness about the characteristics of smokers using a questionnaire by the officer. Analysis of data using statistical multivariance. The results of the research article health warnings on a cigarette can alter consciousness quit smoking the next 12 months amounted to 74.2% of smokers. Picture health warnings on a cigarette can alter the consciousness of quit smoking the next 12 months amounted to 91.2% of smokers. Cigarettes contain writings average time quitting is 50.42 months and picture health warnings on a cigarette average of 18.78 months to quit smoking. There is a significant difference in the average time a smoker stopped smoking after writing and picture health warnings. We conclude that text health warnings and picture health warnings on a cigarette can raise awareness to quit smoking.]]>
<![CDATA[Microstructural aspect of pineal body: pinealocytes population ]]>
<![CDATA[Gede Wirata]]>;
<![CDATA[Putu Nia Calista Santoso]]>;
<![CDATA[Putu Ayu Utami Dewantari]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.151
<![CDATA[Background: Pineal tissue was compound with 2 types of cell known as pinealocytes and astrocyte cell. Furthermore, microanatomical research of pineal body is a rare procedure conducted for several years even in Indonesia, and its anatomical aspect needs to be explained.  Aim: enrich the scope of knowledge related to mammalian pineal within the pineal body. Methods: 3 Wistar rats (Rattus novergicus), especially their pineal tissue, was extracted by pinealectomy method as a histotechnical procedure in a laboratory setting was prepared. Result: Pinealocytes characteristic are basophilic, large, regularly nucleus and a lot of mitochondria. On the other side, astrocyte has longer cytoplasmic processus found around the perivascular area and among the pinealocytes one. Conclusion: The quantities of pinealocytes appear as a most dominant cell that fills the inner part of the pineal body and probable to synchronize the production of melatonin and entirely supported by their neighbor, astrocyte cells. Keywords: histotechnical method, pinealectomy, epiphysis]]>
<![CDATA[Overview of adherence and factors related to medication adherence in hypertensive patients at Puskesmas Tembuku 1 in 2017 ]]>
<![CDATA[Thivyaroobini Ramah]]>;
<![CDATA[Komang Ayu Kartika Sari]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.153
<![CDATA[Background: Hypertension remains a public health issue in Indonesia as its prevalence increases considerably. Adherence to treatment is an important factor in the long-term health and well-being of hypertensive patients. Basic Health Research (Riskesdas) in 2007 reported that the prevalence of hypertension in the population aged over 18 years in Indonesia is as high as 31.7%, of which only 7.2% known that they had hypertension and only 0.4% took antihypertensive medications. Coverage of hypertension cases at Puskesmas Tembuku I in 2016 increased by 50% from the previous year, from 292 cases to 584 cases.Methods: The research was conducted in the coverage area of Tembuku I Community Health Center, Bangli Regency, in 2017. The descriptive cross-sectional method was used in this research. 81 respondents were chosen as research sample using non-probability consecutive sampling method. Primary data were collected through interviews on the research sample using questionnaire and Morisky Medication Adherence Scale (MMAS-8).Results: Most of the respondents had low medication adherence (96.3%), followed by moderate adherence (3.7%). None of the respondents had high medication adherence. Most of the respondents had low knowledge of hypertension (70.4%) and had sufficient access to healthcare facilities (71.6%). Most of the respondents reported high family support (93.8%), and high support from healthcare officials (71.6%). Most of the respondents (97.5%) reported high motivation.Conclusion: Low medication adherence and low knowledge regarding hypertension were observed, despite sufficient access to healthcare facilities, high family and healthcare officials support, and high motivation in hypertensive patients.]]>
<![CDATA[Association between educational level and hypertension with decrease of cognitive function among elderly at Puskesmas Mengwi I ]]>
<![CDATA[Vijay Ramachandran]]>;
<![CDATA[Putu Aryani]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/ism.v9i1.154
<![CDATA[Background: One of most emerging disease in elderly is the decreasing of cognitive function. Some factors that could affect cognitive function are sociodemographic factors such as genetics, age, gender, educational level, occupation also some diseases like a cerebrovascular disease, metabolic disease, brain tumor, and head trauma.Methods: The purpose of this research was to understand the association between educational level and hypertension with a decrease of cognitive function in elderly. This research was analytic cross-sectional study. The number of samples that obtained was 41 elderly who met the inclusion criteria. The sample data obtained by filling an MMSE questionnaire to aces cognitive function.Results: In general, 16 from 41 sample (39%) has a decrease in cognitive function. Bivariate analytic with chi-square method showed that there’s a significant relationship between educational level and a decrease of cognitive function (p= 0.001) while also showed that there’s no significant relationship between hypertension and decrease of cognitive function.Conclusion: It can be concluded that there was a significant relationship between educational level and a decrease of cognitive function in elderly but no significant relationship between hypertension and decrease of cognitive function in elderly. The results of this study were expected to be used as a basis for further research in the future.]]>
<![CDATA[Prevalence of diabetic retinopathy among diabetes mellitus type 2 patients at Diabetes Center of Sanglah General Hospital, Bali ]]>
<![CDATA[Gopi Krishnan]]>;
<![CDATA[AA Ngurah Subawa]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.155
<![CDATA[Background: Diabetic retinopathy is one of the most common microvascular complications of diabetes mellitus. A prevalence study could contribute in explaining the pattern and giving the perspective of how a community deals with diabetes and its complications.Methods: This study was conducted to determine the prevalence of diabetic retinopathy in patients with type 2 diabetes mellitus at the Diabetic Center of Sanglah General Hospital. This study used a descriptive cross-sectional study using secondary data from medical records of patients with diabetes mellitus type 2.Results: 1070 patients with type 2 diabetes mellitus obtained from January – December 2014. 6.92% patients have suffered from retinopathy, and 93.08% have not suffered from retinopathy. Distributions of patients who suffered from retinopathy were mostly from the age group of 50-59 years old.Conclusion: Only 6.92 % of type 2 diabetes mellitus patients in Sanglah Hospital had suffered from the complication of diabetic retinopathy in the year 2014. ]]>
<![CDATA[The compliance of hypertension patients in taking medication at Sukasada II Primary Health care from January - March 2016 ]]>
<![CDATA[Shobana Raveendran]]>;
<![CDATA[Komang Ayu Kartika Sari]]>
<![CDATA[ Intisari Sains Medis Vol. 9 No. 1 (2018): (Available online: 1 April 2018) ]]>
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DOI: 10.15562/ism.v9i1.156
<![CDATA[Background: Hypertension is a chronic disease where the adherence to therapy should be given serious attention. Compliance behavior is to obey the doctor's advice or procedure from the doctor about the use of drugs which had been prescribed by a consultation process between the patient and the patient's family physician. The health providers were influenced by two factors: behavioral and non-behavior factors which determined or shaped by three main factors such as predisposing factors, enabling factors, and reinforcing factors. The aim of this study to assess the compliances of taking medication in hypertensive patients at the Sukasada II Buleleng primary health care.Method: It was a quantitative descriptive study. The respondents were all hypertension patients who come to the Sukasada II primary health care from the period of January to March 2016. Data were obtained through interviews and questionnaires distributed to respondents who met the inclusion criteria and exclusion. The univariate and bivariate analysis was conducted in this study.Results: The results of the research show the number of 84 sample contained 1 subjects with good adherence, 14 subjects with moderate adherence, and 69 subjects with less adherence. The cross tabulation showed that poor medication adherence in the elderly (90.9%), followed by male gender (84.1%), low education (82.7%), higher knowledge (85.0%), perception at close distance (85.7%), travel time ≥ 15 minutes (86.0%), route conditions (84.1), do not have access difficulties (83.9), good family support (82.9), the low role of health care (100%), and did not have any comorbidities (83.1%).Conclusion: The trend of hypertensive patients that are not taking medication mostly come from submissive to men, senior citizens, low educational level, and lesser role of healthcare personnel.]]>
