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Dr. Waras Nurcholis, MSi
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INDONESIA
Jurnal Jamu Indonesia
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : 10.29244
Core Subject : Education, Agriculture,
Agriculture, Biological Sciences & Forestry Other
Jurnal Jamu Indonesia (JJI) didedikasikan untuk pertukaran informasi dan pemahaman keilmuan yang meluas mengenai pengembangan dunia jamu melalui penerbitan makalah-makalah Ilmiah. Tema makalah ilmiah yang menjadi lingkup JJI meliputi tema riset jamu dari hulu kehilir yang tidak terbatas pada riset etnobotani dan pengetahuan lokal, eksplorasi, Konservasi, Domestikasi sumberdaya hayati terkait jamu, pemuliaan varietas, pengembangan Good Agricultural and Collection Practices (GACP) bahan baku jamu, pengembangan standar bahan baku dan produk jamu, pengembangan produk jamu, Identifikasi senyawa aktif serta sintesisnya, Mekanisme kerja bioaktivitas formula jamu, aspek sosial dan ekonomi terkait dengan pengembangan jamu.
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Articles 5 Documents
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Search results for , issue "Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia" : 5 Documents clear
Saponin Pada Bawang Putih Lokal Indonesia dan Potensi Biologinya (Saponins in Indonesian Local Garlic and Their Biological Potential) Balqis; Betty Lukiati; Mohammad Amin; Agus Muji Santoso; Jeni; Widodo Widodo
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

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Abstract

This study aims to determine the various kinds of compounds from the saponin group found in local Indonesian garlic and map the biological potential of these compounds, especially the potential in the health sector. Saponins are a group of compounds characterized by the presence of foam. Saponins have various benefits both in the health, agriculture, animal husbandry, and also in the food and cosmetic industries. Fifteen compounds from the saponin group were identified from local Indonesian garlic obtained from West Papua, using Liquid Chromatography Mass Spectrometry (LCMS) and validated based on their similarity with the NCBI PubChem database. Saponin compounds in local Papuan garlic, then, their biological potential was mapped using the PASS Server and showed that there were seventeen kinds of biological potential in the saponin compound group from Indonesian local garlic. The three most dominant potencies are as anticancer, antifungal, and hypolipemic. Based on this research, it can be concluded that Indonesian local garlic has great potential to be developed and applied in the health sector, especially as an anticancer related to the saponin content in tubers.
Comparison of Antibacterial Activities of Ethanol and Methanol Extracts of Early Flower Leaves (Clitoria Ternatea L.) against Escherichia Coli ESBL (Extended Spectrum Beta Lactamase) Susi Rahmawati; Ahwan Abdul; Fadilah Qonitah
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

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Abstract

Inappropriate use of antibiotics can lead to bacterial resistance. Extended Spectrum Beta Lactamase (ESBL) is a bacterium that is resistant to beta-lactam antibiotics such as penicillins, cephalosporins and monobactams. One example of this bacterium is Escherichia coli which can cause a number of diseases such as urinary tract infections, respiratory infections, sepsis and meningitis. The leaves of the telang flower (Clitoria ternatea L.) contain a number of compounds that have antibacterial activity which are expected to be an alternative for the treatment of infections caused by ESBL Escherichia coli. This study aims to determine the antibacterial activity of ethanol and methanol extract of telang flower leaves against Escherichia coli ESBL and to compare the activities of the two extracts. The test method is experimental, namely measuring the antibacterial activity of the extract using the disk diffusion method. The results of the phytochemical screening test conducted showed that the extract tested positive contained flavonoids, alkaloids, phenolics, saponins, tannins and terpenoids. The results of the research related to the antimicrobial activity of the concentrations of 25%, 50% and 100% methanol extract produced inhibition zone diameters of 7.4 mm, 7.8 mm and 8.1 mm, while the ethanol extracts were 7.3 mm, 7.4 mm. , 7.9 mm. The positive control used, namely gentamicin, produced an inhibition zone of 9.8 mm. These results indicate that the methanol and ethanol extract of telang flower leaves affected the growth of Escherichia coli ESBL and there was a difference in the antibacterial activity of the two extracts based on statistical analysis with the Anova test with p value <0.05.
Estrogenic Effects of Kebar Grass (Biopyhtum Petersianum) in 96% Ethanol Extract and Various Solvent Fractions Mulyati Effendi; Yulianita; Nina Herlina; Wilda Nurhikmah
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

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Abstract

This study aimed to compare antioxidant, antibacterial and toxicity tests of various types of kesambi tree bark extract (Schleichera oleosa (Lour) Oken). The research stages included extraction of kesambi stem skin from Mancak Serang sub-district with multilevel maceration techniques using 3 solvents: Methanol, n-hexane, and ethyl acetate. The extract was then tested for antioxidant activity, antibacterial, and toxicity. The results of antioxidant testing using the DPPH method, antibacterial with agar diffusion method, and toxicity test with BSLT method, the results showed that ethyl acetate extract had better antioxidant activity (IC50 7,723 ppm.) compared to extract of methanol (IC50 7,801 ppm), and n-hexane extract (IC50 8,568 ppm). Antibacterial activity showed the ability to inhibit the growth of Streptococcus aureus compared to Escherichia coli at a concentration of 10000 ppm, and the results of the toxicity test showed that ethyl acetate extract had better activity (LC50 305,17 ppm) than n-hexane extract (LC50 374, 96 ppm) and methanol extract (LC50 431,26 ppm).
The effect of Material to Solvent Ratio to The Flavonoid Content and Free Radical Scavenging Activity of Extract of Morinda Citrifolia L Leaves Septiana Laksmi Ramayani; Fitria Rohmawati; Yasmine Savira Rahmadani
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

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Abstract

The flavonoid compound in Noni leaves (Morinda citrifolia) are efficacious as free radical scavengers. This research aimed to know the influence of the ratio of materials and a solvent (M:S=1:10; M:S=1:15; M:S=1:20) on the flavonoid content and free radical scavenging activity of extract of noni leaves. Extraction was carried out using the Microwave Assisted Extraction method and the free radical scavenging activity were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The results showed that the material-solvent ratio had a significant effect on the yield, total flavonoid content, and free radical scavenging activity. The material to solvent ratio 1: 20 resulted in the highest yield, total flavonoid content, and free radical scavenging activity compared to other solvent-solvent ratios.
Characterization and The Effects Analysis of Purple-fleshed Sweet Potato Extract (Ipomoea batatas [L.]) Administration on Triglyceride Concentration and Pancreatic Histopathology Profiles of Triton X-100-induced Hyperlipidemia in Rats Kintoko; Hardi Astuti Witasari; Rizky Nurdhillah; Tsania Taskia Nabila
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Pusat Studi Biofarmaka Tropika LPPM IPB; Tropical Biopharmaca Research Center - Bogor Agricultural University

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Abstract

Hypertriglyceridemia occurs when the triglyceride levels are increasing from the normal (>150 mg/dL) and it causes pancreatitis at a dose of more than 885 mg/dL. The triglyceride-lowering medicines consumption has several side effects on various organ systems. The plant-based medicine (phytomedicine) alternatives have been observed as the synthetic medicine substitution. Purple-fleshed sweet potato (Ipomoea batatas [L.]) contains anthocyanin that has proven to carry out the antioxidant mechanism and the capability to be used as anti-hypertriglyceridemia. This study aims to identify the activity of purple-fleshed sweet potato extracts on triglyceride levels and the histopathological profile of rats' pancreas-induced Triton X-100. Twenty-five male Wistar rats of week 8th were divided into five groups. The normal (N) group was treated with saline solution, and the treatment (T) groups were a single dose of 100 mg/kg of body weight (BW) Triton X-100 and purple-fleshed sweet potato extracts of 175 (T1); 350 (T2); and 700 (T3) mg/kg BW, while the negative (C-) control group was mere induced by a single-dose Triton X-100 of 100 mg/kg BW. The blood serum was isolated and the pre-and post-test was subsequent conducted. The triglyceride serum levels and histopathological data were analyzed by the Kolmogorov-Smirnov normality test and Kruskal-Wallis post-test statistical analysis. The results showed that Triton X-100-induced treatment could significantly increase the triglyceride levels compared to the normal group (P<0.05). The purple-fleshed sweet potato extracts started to lower the triglyceride level at a dose of 700 mg/kg BW (51.83 ±19.15(%)). The extract doses of 175 and 350 mg/kg BW could not reduce the triglyceride level significantly (3.03±2.77 and 5.63±4.24 (%), respectively). A dose of 700 mg/kg BW did not damage the exocrine gland and Langerhans islet of hyperlipidemia rat pancreas treated by Triton X-100. 

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