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Jurnal Respirasi (JR)
Published by Universitas Airlangga
ISSN : 24070831     EISSN : 26218372     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Respirasi is a National journal in accreditation process managed by Department of Pulmonology & Respiratory Medicine Faculty of Medicine Airlangga University - Dr. Soetomo General Hospital, Surabaya. Publish every January, May, September every year with each of 5 (five) complete texts in Indonesian.
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Articles 15 Documents
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Search results for , issue "Vol. 10 No. 1 (2024): January 2024" : 15 Documents clear
Lung Abscess Located in Lesion of Lung Tumor and Multiple Cavities due to Pulmonary Tuberculosis: A Case Report Sri Indah Indriani; Elvando Tunggul Mauliate Simatupang; Adityo Wibowo; Andreas Makmur; Wiwit Ade Fidiawati
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.55-60

Abstract

Introduction: People with tuberculosis (TB) have an increased risk of pulmonary cancer. They are also disproportionately affected by risk factors like immune suppression, smoking, and alcohol misuse. A lung tumor is reported to have occurred after an episode of TB, but we reported a patient with a lung tumor with co-infection TB and lung abscess at the same time. Case: A 73-year-old man was hospitalized at Arifin Achmad General Hospital, Pekanbaru, with a 3-day history of bloody cough 2-3 times a day, 1-2 tablespoons estimated by the patient for blood from the cough. The patient had a cough with white phlegm in the last 4 months before the bloody cough. The patient also had a fever, night sweats, a limp body, decreased appetite for 6 months, and decreased body weight by 15 kg in the last year. Heterogenic consolidation on the superior lobe of the lung with prominence compression and irregular boundaries in the apex was found. We found an air bronchogram and multiple cavities with air-fluid levels inside the lesion. We also found a satellite nodule in the inferior lung and a mass connected with the chest wall. GeneXpert showed low detection for Mycobacterium tuberculosis. The patient was diagnosed with a left lung abscess, pulmonary TB, left lung tumor T4N2M1a, unspecified type of tumor stage IVA PS2, and osteoporosis. Conclusion: Lung tumors could also be diagnosed with co-infection TB. Proper diagnosis to make sure cancer and TB are co-infected is necessary. Therefore, it will not be just a single disease that is treated.
Cycloserine- and Fluoroquinolone-Induced Seizure in Multidrug-Resistance Tuberculosis (MDR-TB) Patient: A Case Report Dewi Behtri Yanifitri; Yunita Arliny; Wilia Aprilisa Utami; Wira Winardi
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.61-68

Abstract

Introduction: Multidrug-resistant tuberculosis (MDR-TB) is a type of tuberculosis (TB) that is resistant to at least two of the most effective first-line anti-TB drugs, isoniazid (H) and rifampicin (R). Cycloserine (Cs) and levofloxacin (Lfx) are second-line anti-TB drugs used in MDR-TB therapy. Even though they are considered to have high effectiveness, both drugs have the potential to cause side effects. One important side effect is neurotoxicity. Seizures have been reported as a common complication of some drugs. Case: A 39-year-old man was diagnosed with MDR-TB and was treated with individual regimens consisting of Lfx, bedaquiline (Bdq), linezolid (Lzd), clofazimine (Cfz), and Cs. After consuming anti-TB drugs for 27 days, the patient had seizures several times. The patient experienced full-body seizures and loss of consciousness during the seizures. Cs and Lfx were discontinued and replaced by other regimens. Serial electroencephalogram (EEG) showed normal results. After Cs and Lfx were discontinued, the patient never had another seizure. Conclusion: Management of MDR-TB is sometimes complicated because of severe drug side effects. Patients taking Cs and fluoroquinolones (FQs) should be advised to report any sign of seizure or changes in mental status to their healthcare provider.
Needle Aspiration in Tuberculosis-Associated Secondary Spontaneous Pneumothorax Ni Wayan Candrawati; Putu Gita Indraswari; Ni Luh Gede Yoni Komalasari
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.50-54

Abstract

Introduction: The management of tuberculosis-associated secondary spontaneous pneumothorax mostly requires chest tube insertion for complete drainage and resolution. We reported a case of tuberculosis-associated secondary spontaneous pneumothorax that improved with needle aspiration. Case: A 29-year-old female with pulmonary tuberculosis presented with sudden onset shortness of breath. Chest examination revealed asymmetry, decreased vocal fremitus, hypersonor, and decreased vesicular sound in the right lung field. Chest radiograph showed right pneumothorax with a 2 cm intrapleural distance. Needle aspiration was performed because the patient refused chest tube insertion. The first needle aspiration evacuated approximately 615 cc of air. The second needle aspiration was repeated 24 hours later due to clinical deterioration, and 610 cc of air was evacuated. Chest radiograph evaluation on the 6th day of treatment showed no pneumothorax. During hospitalization, the patient received oxygen therapy, anti-tuberculosis drugs, chest physiotherapy, and other symptomatic therapies such as mucolytics. The patient's condition improved, and she was discharged on the 9th day of hospitalization. Tuberculosis-associated secondary pneumothorax occurs in 1-3% of cases. Conclusion: Needle aspiration is a therapeutic modality for tuberculosis-associated secondary spontaneous pneumothorax. This modality has several advantages, including shorter length of stay, less cost and pain, and fewer complications. Needle aspiration combined with oxygen therapy, anti-tuberculosis drugs, and chest physiotherapy should be the modality of treatment for tuberculosis-associated secondary pneumothorax.
Pneumoascariasis: Ascaris Worm Infestation in the Lungs Antonio Ayrton Widiastara; Esmeraldito Ferreira; Sukmawati Basuki
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.69-75

Abstract

Pneumoascariasis is an infestation from one of the most common worms or helminths found on earth in the respiratory system. The worm is called Ascaris lumbricoides, which penetrates and infests the human body through the fecal-oral process. The fertilized Ascaris ova, or simply egg, would develop into larvae, which then move to the liver and lungs through the portal vein system. These larvae will soon develop into mature worms in the human respiratory system, inside the lungs, particularly in the bronchioles. These Ascaris larvae trigger common symptoms such as persistent cough, shortness of breath, and wheezing. To diagnose this condition, supplementary examinations are necessary since it is difficult to diagnose only by history taking and some physical exams. Additional exams include chest X-rays that, at one point, display lung infiltration. The chest computed tomography (CT) scan shows ground-glass opacity and a classic inflammation marker called Charcot-Leyden crystals that are most likely present. Pneumoascariasis is often misinterpreted and misdiagnosed. Therefore, this literature review was made to further understand about pneumoascariasis.
Corona Virus Disease 19 (COVID-19) Patient Profile in Klungkung Ni Komang Ari Sepriyanti; Erwin Winaya; I Wayan Ardyan Sudharta Putra
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.1-5

Abstract

Introduction: Despite the effective global mass vaccination programs, which included booster shots, the emergence of new SARS-CoV-2 strains threatens to undo the enormous success achieved thus far in stopping its spread. This study aimed to assess the demographics of COVID-19 patients from February to May 2021. Methods: Data were collected using secondary data from the medical records of Klungkung Regional General Hospital, Klungkung, at the time range according to the study period. Statistical Package for the Social Sciences (SPSS) version 25.0 for Windows and Microsoft Excel 2016 were used for the statistical analysis. All quantitative data, such as age, length of stay, and neutrophil-to-lymphocyte ratio (NLR), were estimated using central location measures (mean range). Proportions were used to describe qualitative or category variables. Results: The demographic description of COVID-19 patients at Klungkung Regional General Hospital, Klungkung, found an average age of 51.94 years old. More patients were found to be male (55.4%) and did not have comorbidities (55.3%). Fourteen patients (14.4%) were gravid, and 37 patients (17.8%) were treated in the Intensive Care Unit (ICU). A total of 61 patients (29.3%) had desaturase with an NLR (mean) of 6.97 (51% increase). The average length of stay was 10.16 days, with the result of 24 patients dying (11.5%). Conclusion: Patients with COVID-19 were found to have milder symptoms with less use of the ICU, not all of them experienced decreased saturation, and the case fatality rate was 11.5%.
Antibiotic Susceptibility Patterns among Indonesian Adults Hospitalized with Pneumonia Afan Fatkhur Akhmad; Maria Ulfa; Momoyo Azuma
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.6-13

Abstract

Introduction: Pneumonia continues to be a global issue with significant morbidity and mortality rates. Increased multidrug-resistant (MDR) bacterial pneumonia, aging populations, chronically ill patients, and inadequate initial antibiotic therapy increase hospitalized pneumonia patients' morbidity and mortality. This study aimed to analyze the microbiological pattern and choose a therapy based on local antibiotic susceptibility patterns. Methods: From January 2020 to December 2022, a retrospective cross-sectional study was conducted on hospitalized pneumonia patients at Haji General Hospital, Surabaya, Indonesia. Data from medical records were gathered to illustrate patient features, bacterial culture, and antimicrobial susceptibility tests. This study included 172 patients. In this study, no specific statistical analysis was performed. The data were reported as a percentage (%).  Results: The patients were mostly 56-65 years old (36.6%) and male (55.2%). The most common comorbidities were cardiovascular disease (17.3%), and the others were diabetes mellitus (14.0%), cerebral vascular attack (CVA) (10.7%), and coronavirus infection (8.9%). Based on the sputum culture, the bacteria identified were Klebsiella pneumoniae (25.0%), Pseudomonas aeruginosa (20.9%), Acinetobacter baumannii (15.7%), and Escherichia coli (11.6%).  The most common bacteria isolated from sputum cultures was Klebsiella pneumoniae, which was more susceptible to amikacin and meropenem.  Conclusion: Only amikacin was an antibiotic susceptible to four primary pathogens. Rates of resistance to ciprofloxacin and ceftriaxone were high, and these empiric antibiotics should be used with caution in these patients.
The Role of Genome-Wide Association Study in Pulmonary Disease Diagnostics: A Review in Medical Bioinformatics Rossalyn Andromeda; Irandi Putra Pratomo; Ahmad Fauzi; Tutug Kinasih; Prasenohadi Prasenohadi; Arif Santoso; Kentaro Tokumo
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.76-84

Abstract

Biomedical science, which initially required only conventional research in the laboratory, currently involves information technology and has created bioinformatics in its development. Bioinformatics, a branch of biology, quantitatively analyzes information within biological macromolecules using software. Contemporary applications of bioinformatics have advanced biotechnological, medical, and pharmaceutical practices. Among the established applications of bioinformatics is diagnosing lung diseases using the genome-wide association study (GWAS) technique. Owing to sequencing technology and rapid computational methods, this technique is applied to analyze the link between genes with essential traits in the population, thus mapping the target genes to diagnose and treat diseases. The lung diseases diagnosed using GWAS include the responsible locus in asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Moreover, it can identify the treatment for COPD and suggest a new locus in lung cancer. Advancing the current gene-mapping technology demands genotype and phenotype data to study disease-linked genomes. Currently, bioinformatics is barely known and receives little attention in Indonesia. However, it can grow rapidly through open-source basis data and cross-disciplinary collaboration.
Vitamin D, Body Mass Index, and Total Lymphocyte Count in Drug-Sensitive and Drug-Resistant Tuberculosis Patients in Banjarmasin Soraya Riefani; Juhairina Juhairina; Mohamad Isa; Erna Kusumawardhani; Haryati Haryati; Shaogi Syam; Ira Nurrasyidah
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.14-22

Abstract

Introduction: Tuberculosis (TB) remains a global health problem that causes high morbidity and mortality. Based on its classification, TB is divided into drug-sensitive (DS) and drug-resistant (DR). Several risk factors susceptible to TB are malnutrition with low body mass index (BMI), vitamin D deficiency (VDD), and low total lymphocyte count (TLC) related to low immune status. This study aimed to examine the relationship between vitamin D (VD), BMI, and TLC in the TB population in Banjarmasin. Methods: This was an analytic observational study with a cross-sectional design. The total study sample was 42 patients, confirmed by rapid molecular testing, who had not been treated for TB in Banjarmasin from January to May 2023 and met the inclusion and exclusion criteria. Chi-Square and Fisher's exact statistical tests were used to see the relationship between VD, BMI, and TLC in DS TB and DR TB. Results: The median age of DS TB was 38 (24-52) years old, and DR TB was 51 (37-58) years old. Most of the gender was male (24 patients/57.1%). There was a statistically significant difference between VD and BMI in DS TB and DR TB (p = 0.048; p = 0.019). There was a significant relationship between VD and TLC in DS TB and DR TB (p = 0.048). Conclusion: VD and BMI significantly differed in DS TB and DR TB. There was a significant correlation between VD and TLC in TB patients.
Comparison of Forced Expiratory Flow (FEF) 25-75% between Post-COVID-19 Patients with Different Severity at Universitas Gadjah Mada Academic Hospital Muhammad Khidir; Siswanto Siswanto; Henda Ageng Rasena; Roihan Mohamad Iqbal; Rahmaningsih Mara Sabirin; Rakhmat Ari Wibowo; Sani Hadiyan Rasyid
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.23-29

Abstract

Introduction: Shortness of breath is the most distressing long COVID-19 symptom associated with the decline of small airway function, as shown by a decrease in forced expiratory flow (FEF) 25-75% value in the spirometry test. This study aimed to compare FEF 25-75% values as a predictor of small airway disease between mild-moderate and severe-critical long COVID-19 patients. Methods: This study used a prospective cohort design that included 24 post-hospitalized COVID-19 patients who came to the long COVID-19 clinic at Universitas Gadjah Mada Academic Hospital (UGM AH), Yogyakarta. The subjects were divided into mild-moderate and severe-critical groups based on the World Health Organization (WHO) classification. The subjects were tested for spirometry three months after the onset of COVID-19 symptoms. The comparison of both severity groups used the percent prediction of FEF 25-75% spirometry results. The value was interpreted as abnormal if the predicted FEF 25-75% value was below 65%. Results: There were three (25%) and two (16.67%) subjects with FEF 25-75% predicted below normal values in the mild-moderate and severe-critical groups consecutively, which showed a decline in small airway function. This study showed no statistically significant differences (p-value = 0.882) between the means of FEF 25-75% predicted values of the two groups. Conclusion: A small proportion of post-COVID-19 syndrome patients had small airway disease, and there were no statistical differences in small airway function between the groups.
Thymoma Profile at Dr. Moewardi General Hospital: Does Thymoma Size Really Affect Distant Metastasis? Novita Silvana Thomas; Fahlevie Fahlevie; Ana Rima Setijadi; Widiastuti Widiastuti; Sastia Rakhma
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.30-35

Abstract

Introduction: Size is a predictor factor of a patient's prognosis and metastasis in solid tumors. This study determined the relationship between thymoma size and distant metastasis. Methods: A cohort retrospective study using medical record data was conducted at Dr. Moewardi General Hospital, Surakarta, from January 2019 to August 2021. Of 1,430 thoracic oncology patients, 150 (10%) had mediastinal mass with thymoma as the majority (48.6%). About 73 thymoma patients were included. The size of the thymoma was the dependent variable, and the metastasis (distant and non-distant) was the independent variable. The cut-off point of thymoma size was determined with receiver operating characteristic (ROC) analysis. The correlation of thymoma size with distant metastasis was analyzed with the Chi-Square test, and p < 0.05 was considered significant. Results: Thymoma was predominated by males (53.4%), the mean age was 43 ± 16 years old, and dyspnea was the most common symptom. Metastatic lesions were found in 87.7% of the patients, and the most common metastatic sites were intrathoracic (79.5%), followed by axillary lymph nodes (49.3%), bone (21.9%), liver (20.5%), and brain (1.4%). The cut-off value of thymoma size was 8.25 cm, indicating that >8.25 cm was categorized as large thymoma. Distant metastasis was found in 86.0% of large thymoma patients. The large tumors tend to spread into various sites (OR = 5.39; 95% CI 2.8-32.6; p = 0.002).   Conclusion: Thymoma must be taken into account when there are male patients in their forties presented with dyspnea and mediastinal mass. The cut-off point of 8.25 cm for the thymoma size can predict distant metastasis.

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