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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Althea Medical Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Respiratory Science

Haryati Haryati

Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine Lambung Mangkurat University, Ulin Regional Hospital, Banjarmasin

Author-ID : 3108559

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Platelet-to-Lymphocyte Ratio (PLR) Profile and Neutrophil-to-Lymphocyte Ratio (NLR) in Lung Cancer Patients in Ulin General Hospital Banjarmasin 2017-2018 Haryati Haryati; Holly Diany
Berkala Kedokteran Vol 16, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Lung cancer is the leading cause of malignancy in the world reaching up to 13% of all cancer diagnoses. Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR), are promising markers of inflammatory prognosis, clinical decisions for proper management of lung cancer patients. The research used a retrospective analytic observational study as its research method. Samples were taken from Pathology Anatomy Laboratory, and the medical record data of lung cancer patients in Ulin General Hospital Banjarmasin from 2017 to 2018. Male lung cancer patients have percentage of 72% with PLR NLR values by sex are not much different p>0.05. 23% of patients were aged ≥ 65 years and 77% were aged £ 65 years with value p>0.05. Adenocarcinoma reaches 65% with p>0.05. Most metastases are 44% pleural effusion with value p>0.05. Percentage of advanced stage is 90% with a higher PLR NLR value at the end stage. There is a meaningful relationship of NLR with lung cancer stage p<0.05, but no relantionship with PLR p>0.05. PRL and NRL are increased at advanced stage. NRL and PRL did not differ significantly based on age, sex and histology of lung cancer. Keywords: Platelet-to-lymphocyte ratio (PLR), Neutrophil-to-lymphocyte ratio (NLR), lung cancer

Stage 4 Lung Cancer with Brain and Pericardial Metastases Which Are First Considered as Pulmonary Tuberculosis Infection and Heart Failure Haryati Haryati; Marsheilla Riska
Berkala Kedokteran Vol 16, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Lung cancer and pulmonary tuberculosis become a global problem in the world. The similarities of clinical symptoms and radiological appearances often complicates diagnosis especially in TB endemic countries. A 43-year-old man presented with shortness of breath for 6 months, accompanied by intermittent cough mixed with blood streaks. He had been taking anti-tuberculosis for 2 months, but there’s no improvement. On physical examination, ronchi were heard in the lower 2/3 of the right lung and heart sounds diminished. Motoric movement of the left hand was difficult to grasp hard. A contrast-enhanced CT scan of the head revealed hyperdense multiple nodules. Chest X-ray showed cardiomegaly with right lung consolidation and a primary malignant right lung mass accompanied by pericardial effusion at thoracic CT scan. Cytology and EGFR examination of pericardial effusion found adenocarcinoma metastasis with exon 18 and 21 mutations. Evaluation of clinical symptoms and radiological examination during tyrosine kinase inhibitor (TKI) therapy showed improvement. Lung cancer can resemble pulmonary tuberculosis in various manifestations. Adenocarcinoma with positive EGFR mutations is more commonly found in Asians. Cytology and EGFR examination of pericardial effusion became the basis of diagnosis in this case. He was given TKI therapy. Re-evaluation must be carried out in patients who do not improve with antibiotics or anti-tuberculosis. Patient reported a good response after consuming EGFR-TKI. Keywords: lung cancer, tuberculosis, tyrosine kinase inhibitors

Tocilizumab In Severe To Critical Confirmed COVID-19: A Case Series At Ulin Referral Hospital Of South Kalimantan Haryati Haryati; Fidya Rahmadhany Arganita; Widya Ramadhaniati
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2862

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes pneumonia. The clinical severity of COVID-19 is related to the presence of a “cytokine storm” that causes overproduction of inflammatory mediators such as interleukin (IL)-6. Tocilizumab (TCZ) as an IL-6 inhibitor is subject of major studies as a potential therapeutic agent. This study reported 20 cases of COVID-19 patients being treated with the IL-6 inhibitor TCZ beside standard therapy. Patients were followed up on clinical, laboratory and chest x-rays before and after the administration of therapy which were report descriptively. The oxygen saturation of patients who survived shows rapid improvements. The laboratory results showed that CRP decreased after administration TCZ immediately. Meanwhile, other markers improve slowly, such as leucocytes, Neutrophyl Lymphocyte Ratio (NLR), Absolute Lymphocyte Count (ALC) and Lactate Dehydrogenase (LDH) but ferritin was tended to fluctuate. In chest X-ray’s, infiltrate bilateral on admission began to diminished until almost disappeared on the 14th day after TCZ. From 20 patients, 80% of patients survived with improvement in clinical, laboratory and chest X-rays, while the rest death with a good response on first therapy but fluctuated and worsened before death. Tocilizumab can be considered to provide clinical improvements in severe and critical COVID-19 patients.

Immune-checkpoint Inhibitor Treatment of Non-Small Cell Lung Cancer Patients Haryati Haryati; Ayudiah Puspita Mayasari
Jurnal Respirasi Vol. 6 No. 1 (2020): January 2020
Publisher : Faculty of Medicine Universitas Airlangga

Lung cancer is the primary cause of mortality in the world. It is able to manipulate the host immune response system through many mechanisms, such as through alteration of cytokines structure, forming regulator T-cells, obstruction of cellular immunity function, and the interference of tumor antigen presenting process. The new therapy approachment is produced by stimulating anti-cancer immune response, therefore the growth of lung cancer is able to inhibit. Immune checkpoint inhibition is considered as therapy for non-small cell lung carcinoma (NSCLC) after the unsuccesful treatment by platinum-based chemotherapy. Recent study shows that immune checkpoint inhibition monotherapy is more distinguished as first line therapy than platinum-based chemotherapy. Nonetheless, the effect of immunotherapy is only available for small population (30%) which has more than 50% PD-L1 programmed by the tumor. Therefore, some strategies are investigated to solve this issue. Nowadays, immunotherapy is expected to overcome lung cancer which is still being investigated in many studies.

The First Case of COVID-19 in South Kalimantan Muhammad Nor; Haryati Haryati
Jurnal Respirasi Vol. 6 No. 3 (2020): September 2020
Publisher : Faculty of Medicine Universitas Airlangga

Background: In December 2019, a series of acute respiratory syndromes occurred in Wuhan, China. This syndrome became known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The sudden appearance and rapid global spread of SARS-CoV-2 led World Health Organization (WHO) to declare it as a pandemic disease on March 11, 2020. We will report the first case COVID-19 in South Kalimantan.Case: A 44-year-old man was presented with fever, 7 days before admission. The patient also complained about cough with white phlegm and shortness of breath, accompanied by nausea with heartburn and decreased of appetite. He confessed that he just returned from local transmission areas of COVID-19. From physical examination, it was found SaO2 92% room air with bronchial sounds and ronchi in the lung. Chest X-ray showed peripheral infiltrates and diagnostic swab with RT-PCR in the oropharynx and nasopharynx showed that the patient was infected with SARS-CoV-2. HbsAg marker on this patient was also reactive. The patient then received supportive therapy as well as antiviral therapy. After 10 days of treatment, the patient was already free from the symptom, but swab evaluation remained positive. On the 31st day of treatment, the patient was finally declared cured with a negative swab result.Conclusion: The number of COVID-19 cases has increased from time to time. Holistic treatment and rapid detection greatly affect the prognosis of this disease. Prevention through health protocols is also very important to reduce its spread.

Clinical Characteristics of Hospitalized Individuals Dying with COVID-19 in Ulin Regional Hospital Banjarmasin Haryati Haryati; Mohamad Isa; Ali Assagaf; Ira Nurrasyidah; Erna Kusumawardhani
Jurnal Respirasi Vol. 7 No. 1 (2021): January 2021
Publisher : Faculty of Medicine Universitas Airlangga

Background: Corona Virus Disease (COVID-19) has become a global pandemic and has spread to more than 200 countries including Indonesia. South Kalimantan is one of the provinces in Indonesia that has a high COVID-19 mortality rate (case fatality rate 4.1%). Information about characteristic of mortality patients with SARS-CoV-2 infection in Indonesia was limited. The objective of this study to describe clinical characteristics of COVID-19-confirmed deaths at Ulin Regional Hospital Banjarmasin, as a referral hospital in South KalimantanMethods: Medical records of 108 hospitalized patients dying with COVID-19 between March until August 2020 were collected. The recorded information included gender, age, onset and severity of disease, comorbidities, symptoms, signs, and laboratory findingsResults: The 108 confirmed cases of COVID-19 deaths were mostly male (73.1%) aged <65 years old (85.2%). About 84% of the cases had at least one comorbidity or more, like hypertension (44.4%), obesity (38%), and diabetes mellitus (32.4%). Common early symptoms were fever (91.7%) and shortness of breath (89.8%). Laboratory findings included lympocytopenia and eosinophilopenia (80.6% and 72.2%), increased neutrophil lymphocyte ratio (NLR; 86.1%), decreased absolute lymphocyte count (ALC; 72.2%), and hyponatremia (55.6%). Elevated C-reactive protein (CRP; 92.6%), lactate dehydrogenase (LDH; 91.7%), serum glutamic oxaloacetic transaminases (SGOT; 82.4%), and creatinine levels (57.4%). The majority of non survivors were severe-critical stage with severe acute respiratory distress syndrome (ARDS).Conclusion: In this depictive study, patients with comorbidities and severe-critical stage are at risk of death. Laboratory abnormalities were common in non survivors. Shortness of breath may indicate poor prognosis of COVID-19.

Cholesterol Level in Covid-19 Patients Related to Severity and Mortality: A Case Series and Literature Review Anggarda Kristianti Utomo; Haryati Haryati
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.28

Coronavirus Disease 2019 (COVID-19) is a communicable disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). December 2019 in Wuhan, China, is the time and place where the first pneumonia case which SARS-CoV-2 causes was found, and WHO designated COVID-19 as a pandemic by March 2020. There are reported cases of dyslipidemia associated with SARS patients, albeit rare. Several case reports showed lower cholesterol levels compared to healthy subjects. Therefore, some argued that dyslipidemia could occur in COVID-19. Several studies have revealed that hypolipidemia is positively correlated with the severity of COVID-19. In Ulin Regional Hospital Banjarmasin, several cases found higher cholesterol levels in asymptomatic and mild-moderate COVID—19 survivor compared to patients with severe/critical COVID-19and non-survivor. Two patients in the non-survivor group showed a significant decrease in cholesterol level compared to baseline, and five patients had <150 mg/dL cholesterol level during the examination. Four mild-moderate COVID-19 survivors had cholesterol levels that were greater than 150 mg/dL at the first examination and did not decrease during the evaluation. Cholesterol is thought to play an important role in the pathological development of COVID-19, and it is associated with severity and mortality, which requires further studies.

Chemotherapy in Lung Cancer With Hepatic and Renal Impairment Aida Hastuti; Erna Kusumawardhani; Haryati Haryati
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.42

Chemotherapy is one of the therapeutic modalities for lung cancer. Chemotherapy with anticancer drugs has a narrow therapeutic index and pharmacokinetic variability between individuals. The administration of anticancer drugs should consider many factors that may affect the pharmacokinetics of the drug, such as hepatic and renal function. In lung cancer patients who have hepatic and renal impairment, an adjusted dose of anticancer drug is needed to achieve levels of drug exposure similar to patients who have normal organ function and avoid toxicity. Renal function is calculated by the glomerular filtration rate or creatinine clearance. Assessment of hepatic function can be taken from Child Pugh's score or from bilirubin and aminotransferase enzyme data in patients. In addition, hepatitis screening is also required. The results of the assessment will determine the adjustment dose recommendation for anticancer drugs.

Prognostic Value of the Systemic Immune-Inflammation Index in EGFR Mutation-Positive Lung Adenocarcinoma Patients Treated with Tyrosine Kinase Inhibitors Marsheilla Riska; Haryati Haryati; Eko Suhartono; Tenri Ashari Wanahari
Jurnal Respirasi Vol. 8 No. 3 (2022): September 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Inflammatory parameters calculated from complete blood counts such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) are related to poor prognosis in lung cancer patients. This study aimed to explore a correlation between NLR, PLR, and SII to survival rates in advanced lung adenocarcinoma with tyrosine kinase inhibitors (TKIs) as the main treatment choice. Methods: This was a retrospective observational study of patients with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma treated by TKIs at Ulin General Hospital Banjarmasin from January 2017 to December 2019. The optimal cut-off values for NLR, PLR, and SII were obtained using the receiver operating characteristic curve (ROC). Kaplan–Meier analyses were used to assess the prognostic value of inflammation parameters in overall survival (OS) and progression-free survival (PFS). Results: This study involved 50 samples, 62% male, with an average age of 55.98 years old, 94% in stage IVA, EGFE mutation in exon 19 (58%) and exon 21 (42%). About 58% of patients have a smoking history. The optimal cut-off value for NLR, PLR, and SII was 6.095, 356.935, and 1767.0, respectively. However, only the SII was significantly associated with survival; SII ≥ 1767.0 correlated with shorter OS (18 months vs. 28 months, p = 0.014) and PFS (7 months vs. 12 months, p = 0.004). Conclusion: Pre-treatment SII can be a prognostic factor for survival in EGFR mutation-positive lung adenocarcinoma patients receiving TKIs.

EKSASERBASI ASMA MANDIRI BAGI KADER DESA DI PEMATANG PANJANG KECAMATAN SUNGAI TABUK KABUPATEN BANJAR Fujiati Fujiati; Haryati Haryati; Joharman Joharman; Emmi Erliyanti; Brian Pramana Santoso; Anisa Anisa; Sabrina Wahda Utami; Noor Athiyya
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 6, No 3 (2022): September
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v6i3.10111

ABSTRAKAdanya perubahan lingkungan hidup pada penderita asma memungkinkan terjadinya eksaserbasi dan memperparah kondisi sebelumnya. Eksaserbasi dapat mengganggu aktivitas penderita dan akhirnya menurunkan kualitas hidup penderita asma. Penatalaksanaan asma di era pandemi covid-19 secara mandiri sangat penting. Kegiatan ini harus didukung semua pihak, termasuk akademisi. Namun untuk jangka panjang perlu perantara/mitra yang dapat menjembatani antara akademisi dengan masyarakat. Sasaran strategis kegiatan ini adalah kader Desa Pematang Panjang yang berjumlah 12 orang sebagai mitra dan dipilih oleh masyarakat sendiri. Kader dapat membantu mobilisasi sumber daya masyarakat, mengadvokasi masyarakat serta membangun kemampuan secara mandiri. Akan tetapi untuk keberhasilan kegiatan tersebut diperlukan pengetahuan dari kader. Berdasarkan data, tidak ada kader yang mempunyai pendidikan tinggi. Sebanyak 83,3% kader belum pernah memberikan bantuan dan bimbingan ke masyarakat tentang penatalaksanaan asma secara mandiri. Oleh karena itu dilaksanakan kegiatan pengabdian berupa edukasi tentang penatalaksanaan asma secara mandiri. Diharapkan kegiatan ini dapat meningkatkan pengetahuan kader tentang faktor-faktor yang dapat meningkatkan eksaserbasi asma dan cara pencegahannya, meningkatkan pengetahuan dan keterampilan olahraga pernafasan, pengetahuan dan keterampilan penggunaan nebulizer, serta adanya leaflet tentang pencegahan eksaserbasi asma. Berdasarkan hasil evaluasi pre dan post test dari kegiatan penyuluhan terdapat peningkatan pengetahuan kader mengenai eksaserbasi asma, olahraga pernafasan, dan penggunaan nebulizer (p-value < 0,05). Kata kunci: asma; eksaserbasi; pengetahuan. ABSTRACTThe existence of environmental changes in asthmatics allows exacerbations and worsens the previous condition. Exacerbations can interfere with the patient's activities and ultimately reduce the quality of life of asthmatics. Independent management of asthma in the era of the COVID-19 pandemic is very important. This action must be supported by all parties, including academics. However, in the long term, intermediaries/partners are needed who can bridge the gap between academics and the community. The strategic target of this activity is Pematang Panjang Village Cadres who gather 12 people as partners and are chosen by the community itself. Cadres can help mobilize community resources, advocate for the community and build capacity independently. However, for the success of these action, knowledge from cadres is needed. Based on the data, there are no cadres who have higher education. As many as 83.3% of cadres have never provided assistance and guidance to the community regarding asthma management independently. Therefore, community dedication that is education of self management of asthma held. This action be expected can increase the knowledge of cadres about factors that can increase asthma exacerbations and how to prevent, increase knowledge and skills of respiratory sports, knowledge and skills of using a nebulizer, and presence leaflets about preventing asthma exacerbations. Based on the results of pre and post-test evaluations from this action, there was an increase in the knowledge of cadres regarding asthma exacerbations, breathing exercises, and the use of nebulizer (p-value <0.05). Keywords: asthma; exacerbations; knowledge.

Co-Authors Aida Hastuti Ali Assagaf Ana Rima Andreas Infianto Anggarda Kristianti Utomo Anisa Anisa Arganita, Fidya Rahmadhany Arif Santoso Ayudiah Puspita Mayasari Brian Pramana Santoso Desi Rahmawaty Desi Rahmawaty Desi Rahmawaty Dimas Satrio Baringgo Eko Suhartono Eko Suhartono Eko Suhartono Elisna Syahruddin Elok Hikmatun Nikmah Emmi Erliyanti Ermayanti, Sabrina Erna Kusumawardhani Erna Kusumawardhani Erna Kusumawardhani Erna Kusumawardhani Erna Kusumawardhani Ferry Dwi Kurniawan Fidya Rahmadhany Arganita Holly Diany Ida Ayu Jasminarti Ira Nurrasyidah Jamal Zaini Joharman Joharman Laksmi Wulandari Marsheilla Riska Mohamad Isa Muhammad Nor Nathaniel Aditya Nida Amalia Noni Novisari Soeroso Noor Athiyya Sabrina Wahda Utami Setyawan, Ungky Agus Sita Andarini Sri Melati Munir Tenri Ashari Wanahari Widya Ramadhaniati

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