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Harry Noviardi
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INDONESIA
Jurnal Farmamedika (Pharmamedica Journal)
Published by Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
ISSN : 25026011     EISSN : 26864487     DOI : https://doi.org/10.47219/ath
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Farmamedika dikelola oleh Lembag Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Teknologi Industri dan Farmasi Bogor. Frekuensi penerbitan jurnal sebanyak 2 kali dalam satu tahun pada bulan Juni dan Desember. Kategori tulisan berupa hasil penelitian dari peneliti maupun akademisi dalam bidang Kimia Bahan Alam, Analisis Farmasi, Farmakologi dan Toksikologi, Kimia Medicinal, Biologi Molekular dan Bioteknologi, Farmakoterapi, Farmasi Klinis, Farmasetika dan Teknologi Farmasi, Biologi Farmasi, Manajemen Farmasi, Farmakoekonomi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
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Search results for , issue "Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)" : 5 Documents clear
FORMULASI SEDIAAN GEL EKSTRAK ETANOL BUNGA KUBIS MERAH (Brassica oleracea L.) SEBAGAI ANTIOKSIDAN DENGAN METODE DPPH Ferry Effendi; M Ikhwan Setiawan; Ayu Lestari
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.976 KB) | DOI: 10.47219/ath.v4i1.11

Abstract

Red cabbage flower (Brassica oleracea L.) contains antioxidant compounds with strong activity potential. This research aims to make antioxidant gel preparations using HPMC as a base gel containing red cabbage flower extract with concentrations (% b/b) for F1, F2 and F3 are 5%, 7,5% and 10%, which are then evaluated and tested its antioxidant activities. Testing antioxidant activity is carried out by the determination method of IC50 using the reagent DPPH (Difenil-2-Pikrilhidrazil). From research acquired the value of IC50 for ethanol extract red cabbage flower and vitamin c as comparative compounds is 47,10 ppm and 6,30 ppm. Antioxidant activity of red cabbage flower ethanol extract in gel preparations in each formulation has a IC50 value of 80,15 ppm (F1), 59,71 ppm (F2), and 57,48 ppm (F3). Evaluation ofgel preparation includes homogenity, organoleptic, viscosity and pH. The physical properties test results of gel dosage showed that all the preparations of the homogeneous gel, have a pH between the 5,30-5,70 corresponding to the skin pH, with a viscosity value of 3000-3700 cps, and have a coverage of ≤ 7 cm. Based on the results of this study, it was concluded that red cabbage flower ethanol extract can be formulated in an antioxidant gel with the best concentration is 10%.
ANALISIS STABILITAS LOTION MENGGUNAKAN EMULSIFIER HASIL PENYABUNAN MINYAK DAN ALKALI Armi Wulanawati; Chelsea Epriyani; Elline Sutanto
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.836 KB) | DOI: 10.47219/ath.v4i1.51

Abstract

The lotion is one of the solid dispersion emulsion products with suitable emulsifiers. Lotion is included in cosmetics (personal care) which is usually used to moisturize, soften, and soften the skin. Types of emulsions in personal care are oil in water (o/w) emulsions which tend to be polar in nature. Emulsifiers that are often used in lotion making are emulsifiers that are formed using the saponification method of paraffin oil and triethanolamine alkali. The stability of this emulsion can be influenced by pH and viscosity (polarity) values. Emulsions that have a similar degree of polarity to oil, will tend to be stable. It is known, paraffin has a low polarity, while some other types of oils such as 2-Ethylhexyl Palmitate, Dicaprilyl Ether, Cocoglycerides, Octyldodecanol have a higher polarity, whereas some types of alkalis such as KOH flakes, AMP 95, AMP Ultra PC 3000, Tris Amino Ultra and Neutrol TE have a higher pH than Triethanolamine. Based on these things, the emulsifier in the lotion was formed by reacting stearic acid in various types of oils and alkalis which had higher polarity and pH values than the previous use of oils and alkalis. Mixing between the oil and alkaline phases is carried out at 70−75ºC to facilitate the emulsification process. The results obtained from the lotion emulsion stability test showed that the lotions in all types of oils and alkalis were stable at storage temperatures (room temperature, 45ºC, and 50ºC), and the pH was in the range of 6.75–7.60, but the best lotion emulsions and standards SNI 16-4399-1996 is using an emulsifier composed of Neutrol TE alkali and Octyldodecanol oil which has pH value 6.76-7.03, and viscosity 35000-43000 cP.
ANALISIS AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL 70% DAUN KEMANGI (Ocimum americanumL.) TERHADAP BAKTERI Propionibacterium acnes Triyani Sumiati; Eem Masaenah; Lydia Asriyani
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.446 KB) | DOI: 10.47219/ath.v4i1.52

Abstract

Acne is skin disease caused due to a blockage of the oil gland channel and infection by the bacteria Propionibacterium acnes. Ethanol extract of 70% basil leaves has been known to be potent as antibacterial to Propionibacterium acnes. This study aims to determine the physical quality of gel preparation and antibacterial activity analysis of gel ethanol extract preparation of 70% basil leaves (Ocimum americanum L.) to Propionibacterium acnes bacteria. In this research, ethanol extract 70% of basil leaf is formulated into gel preparation form with various concentration of extract that is 45%, 55%, and 55% then in physical quality test include: organoleptic test, pH, spreading, and viscosity. The gel preparation was then analysed for its antibacterial activity using the diffusion method for the wells. Based on ethanol extract research, 70% of basil leaves had antibacterial activity with drag zone diameter of 5,20 mm (45% extract concentration), 6,06 mm (concentration of extract 50%) and 7,13 mm (concentration of extract 55%). In this study can be concluded that the higher concentration of ethanol extract 70% basil leaves the higher the inhibit zone diameter.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70% DAN INFUSA DAUN KECIPIR (Psophocarpus tetragonolobus (L.) DC.) DENGAN METODE PERENDAMAN RADIKAL BEBAS Eem Masaenah; Anna Priangani Roswiem; Devina Putri
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.731 KB) | DOI: 10.47219/ath.v4i1.53

Abstract

Winged leaf (Psophocarpus tetragonolobus (L.) DC.) has been known to contain vitamin C compounds which can be efficacious as antioxidants. The aims of this study was determine the secondary metabolites contained in 70% ethanol extract and winged leaf (Psophocarpus tetragonolobus (L.) DC) infusion and to test the antioxidant activity of 70% ethanol extract and winged leaf infusion (Psophocarpus tetragonolobus (L.) DC). ) with the free radical reduction method using DPPH. Ethanol extract of 70% winged leaf (Psophocarpus tetragonolobus (L.) DC.) was made with a series of concentrations of 10, 15, 20, 25, 30 ppm and infusion of winged leaf (Psophocarpus tetragonolobus (L.) DC) with a series of concentrations of 75, 100, 125, 150, 175 ppm are both dissolved with methanol pro analysis and DPPH, then their absorbance is measured using a UV-Vis spectrophotometer at a wavelength of 517 nm. Ethanol extract of 70% winged leaf (Psophocarpus tetragonolobus (L.) DC.) Contains flavonoid, saponin, tannin, steroids and winged leaf infusion (Psophocarpus tetragonolobus (L.) DC) contains flavonoid, saponin, tannin. Ethanol extract of 70% winged leaf (Psophocarpus tetragonolobus (L.) DC.) Has antioxidant activity with IC50 value of 22.12 ppm (very strong) and winged leaf infusion (Psophocarpus tetragonolobus (L.) DC.) of 167.03 ppm (weak) and vitamin C as a positive control of 6.82 ppm (very strong).
PERBANDINGAN PENURUNAN TEKANAN DARAH PASIEN BEDAH FRAKTUR DENGAN PREMEDIKASI ANESTESI PETIDIN DAN FENTANIL DI RSUD KOTA BOGOR Siti Mariam; Kiki Fitriana Dewi; Halimatussa’diyah
Jurnal Farmamedika (Pharmamedika Journal) Vol 4 No 1 (2019): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.598 KB) | DOI: 10.47219/ath.v4i1.54

Abstract

Premedication of intravenous anesthesia using the drugs petidine and fentanyl causes side effects of hypoventilation or decreased tidal volume and hypotension. This study aims to determine the decrease in blood pressure in fracture surgery patients at RSUD Kota Bogor. This study was conducted on 100 inpatients in the January-December 2018 period who were given the drugs petidine and fentanyl premedication. This type of non-experimental research with the retrospective data collection, research data were analyzed using the Kolmogorov-Sminorv test and the Mann Whitney test. Data taken included: Medical record number, age, sex, duration of surgery and blood pressure 5 minutes before premedication to 1 hour of surgery. The results found more surgical fracture patients occur in men (63%) with an age range of 40-50 years (29%). The duration of the most operations was 1 hour (62%). The most widely used premedication therapy as a narcotic analgesic drug is fentanyl (70%). The most common decrease in blood pressure is petidine (13.93 mmHg) compared to fentanyl (8.34 mm / Hg). Based on statistical results using the Kolmograv-Smirnov test and the Mann-Whitey test p-value (asymp sig. (2-tailed) showed a p-value of 0.05 (0,000) which means that there is a difference in blood pressure reduction between petidine and fentanyl.

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