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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 13, No 3 (2007)" : 8 Documents clear
NILAI UREUM, KREATININ, DAN PENYINGKIRAN KREATININ DI PENDERITA PENYAKIT GINJAL MENAHUN (KRONIK) I. Ismail; Mutmainnah .; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.910

Abstract

Chronically Kidney Disease (CKD) is still a health problem with a high incidence, complex aetiology, and often without complaintsor clinical symptoms except in the terminal stadium. To know the distribution of CKD according to age, sex group, aetiology, determiningstage of CKD based on creatinine clearance value, a retrospective study was conducted on 88 patients of CKD at Wahidin SudirohusodoPublic Hospital of Makassar from January to December 2004. The diagnosis of CKD was based on serum ureum value (ModifiedBarthelot), serum creatinine value (Jaffe) and creatinine clearance value (Cockroft Gault). Chronically Kidney Disease was found morefrequent in men 59.09% (52 of 88). The peak age prevalence was between 50 to less than < 60 years 29.55%. The eldest patient was 83years while the youngest was 16 years. The most fragment aetiology of CKD was hypertension 18.18% (16 of 88). Based on creatinineclearance values the medium group, severe group, and renal failure group were the age group respectively 3.41%, 19.32% and 77.27%.The prevalence of CKD is found more frequent in 50 less than 60 years of age. Hypertension seems to be the more predominant aetiology,and staging based on creatinine clearance value showed that most patients were in the renal failure group.
IDENTIFIKASI CEPAT MIKROORGANISME MENGGUNAKAN ALAT VItEK-2 prihatini .; aryati .; hetty .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.915

Abstract

Vitek-2 is automatic microbiologic equipment which used to identify antimicrobial sensitivity by micro organism test have been launched in Indonesia. In some private laboratory and hospital this equipment has been used already. The purpose of this study is toknow how to operate this equipment to ID and AST as well as to compare with the conventional methods. The material used to test withthis equipment consist of pure colony culture which derived by suspension of one inoculation to ID or AST card. The reagent consistsonly of saline suspension. After the suspension installed to VITEK2, the result was verified in the printout about 1.5 hours. The colour ofID and AST is difference and couldn’t change with each other. The results are appear more rapid than the others conventional methods.VITEK-2 can be used as a means to diagnose faster than the conventional methods., so that the physician could prescribe earlier as soonas possible to patients and reduced the hospital budgets as well.
TROMBOSITOPENIA PADA PENGOBATAN DENGAN HEPARIN B. Mulyadi,*; J. Soemarsono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.913

Abstract

Heparin induced thrombocytopenia (HIT), a well known side effect of heparin therapy, occurs in 1–5% of adults exposed to heparin.Unlike other drug induced thrombocytopenia, HIT does not usually cause bleeding, but instead cause thrombosis about 50% of HIT.The thrombosis in HIT can lead to limb gangrene or even death. The Importance to know the HIT is the wide use of heparin led tothe increasing recognition of untoward complications including HIT, relatively uncommon but severe side effect of heparin therapy,unpredictable, and difficulty in diagnosing and treating HIT. HIT is mediated by an antibody that recognizes an epitope on the plateletfactor (PF4)-heparin complex. The platelet factor (PF4)-heparin complex binds to FcgRII receptor on the platelet surface and crosslinksthereceptors.Thisinducesintenseplateletactivationandaggregationandsimultaneouslyactivatesbloodcoagulationpathways,thesechangesareprobablythebasisofthethrombosiseventsinHIT.HITwasclassifiedintotype1and2baseonthepathogenesisandtheseverityofHIT.RegularplateletcountmonitoringisbestsuitedforearlydiagnosisofHIT.Functional(serotoninrelease,plateletaggregationtest)andantigenassays(solidphaseenzymeimmunoassay,fluidphase,andparticlegelimmunoassay)areavailabletoconfirmHIT.HITwasmadebaseontheclinicalfindingandlaboratoryexamination.OnceHITisclinicallysuspected,heparinshouldbestoppedimmediatelyandtreatmentwithanalternativeanticoagulant,waitingforlaboratoryconfirmationmaybecatastrophic.Earlydiagnosisof HIT will decrease the morbidity and mortality.
HUBUNGAN ANTARA KADAR HEMOGLOBIN DENGAN KADAR KREATININ SERUM PENDERITA PENYAKIT GINJAL MENAHUN (KRONIS) Rosnety, .; M Arif; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.908

Abstract

Chronically Kidney Disease (CKD) is the health problem of society worldwide, included Indonesia which its amount will increase.Clinical manifestation often following CKD is anaemia which will be severe with the increasing of serum creatinine values. To determinefrequent distribution of anaemia degree and assessing relationship between haemoglobin (Hb) and creatinine concentration in CKDpatients. Retrospective Descriptive Study in CKD patients with anaemia. In the period of May-September 2006, from 50 CKD patientsat the Department of Internal Medicine, Dr.Wahidin Sudirohusodo Hospital Makassar, 38 patients (76%) suffered severe anaemia(Hb < 8 g/dl). Mean value of Hb was 6,85 g/dl and serum creatinine concentration was 11.89 mg/dl. There was a significantrelationship between increasing of serum creatinine and decreasing of Hb (p = 0,013). Majority of CKD patients suffered from severeanaemia, there was relationship between increasing of serum creatinine and decreasing of Hb. To make routine blood tests and bloodsmears in CKD patients is needed, with large of samples to assess the relationship between Hb and serum creatinine.
KAJIAN KELUARGA tHALAssEMIA b-HEMOGLOBIN E Nurul A; Adi K Aman; Ratna A G
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.911

Abstract

HbE-b thalassemia is an inherited hemoglobin disorder of gene combination b thalassemia and HbE. It is caused by thalassemia and hemoglobinopathy gene,which acting as the allele in the same locus of chromosome. The clinical presentation is more severe than HbEhomozygote and almost similar to b thalassemia major. This disease is found predominantly in South East Asia, including Indonesia.The family study is very needed in order to genetic screening to prevent hemoglobinopathy and thalassemia homozygote. The objective ofthis study is to know the pedigree from the daughter who suffer from HbE- b thalassemia which is taken care in the children ward at H.Adam Malik Top Refferal Hospital, Medan. The family study was also done to both father and mother, one sister and to both grandparent.An examination was carried ,which include physical examination, complete cell blood count, peripheral blood morphology, hemoglobinanalysis with Hb-electroforese pH 8.5 agarose medium and read with densitometri, and osmotic fragility examination. From the familystudy was found that her father suffer from HbE heterozygote while the mother suffer from b thalassemia trait and sister got HbE- bthalassemia. The father and mother have no relative acceptance and there is no any blood linkage. Her grandparent could not performthe blood sample because they were have already passed away .
sUrVEI tUrN ArOUND tIME PADA PELAYANAN LABORATORIUM Linda Rosita; O Sianipar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.916

Abstract

Turn Around Time (TAT) is time analysis check the laboratory started by since acceptance sampel still result and inclusive of result which have validated marked with the signature of laboratory doctor. TAT represents the important shares from medical service promisedTAT represents the important shares from medical service promised by laboratory party. Evaluate the TAT started from analysis to equipment of admission filling of request form of inspection laboratory.Evaluate the stuffing of request form met from the condition of sampel and telephone number which can be contacted nothing that filled. sampel and telephone number which can be contacted nothing that filled. and telephone number which can be contacted nothing that filled. TAT of better outpatient from at TAT of at patients take care. The monitoring of TAT shall have the character of the continue and ableThe monitoring of TAT shall have the character of the continue and able to give the feed back so that quality of good laboratory service progressively.
ANTIGEN OMP (OUTER MEMBRANE PROTEIN) salmonella typhi FAGA LOKAL YANG IMUNODOMINAN DAN SPESIFIK TERHADAP ANTIBODI PENDERITA DEMAM TIFOID J. Nugraha; Rahayu Anggraini
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.912

Abstract

Background of this research is that diagnostics of typhoid fever is still a health problem. Widal test, which is the mostly used test in Indonesia, frequently gives false positive results and is not reliable in endemic areas. On the other hand, the other confirmation test, bloodculture, is not sensitive and often give false negative results. OMP (Outer Membrane Protein) is known as a specific part of Salmonellatyphi and fragments of OMP still exist in the patient’s body since early infection until 2–3 weeks thereafter. In this study parts of OMPwhich react specifically with sera of typhoid fever in Indonesia were searched. These specific parts will then be developed as a diagnostickit for typhoid fever. Using Western Blot method, part of OMP will be searched, which is specifically react with sera of typhoid feverpatients in Indonesia. OMP derived from local phage type isolated in Indonesia was used. This OMP was separated with SDS-PAGE 12%and incubated with pooled sera of typhoid fever patients, and sera of control group, that is from Dengue haemorrhagic fever patientsand urinary tract infection with E. coli. Extraction of OMP was done by the method of Matsuyama. Contrary, this research failed to find a particular part of OMP which react specifically with sera of typhoid fever patients. There are certain parts of OMP which react also with sera of DHF & urinary tract infection patients. Our finding was different with the results from Malaysia, where it is reported thatantigen OMP 52 kD react specifically there. In order to develop a diagnostic tool for typhoid fever, we should consider another possiblespecific antigen other rather than using OMP.
INFESTASI PLASMODIUM DALAM SUMSUM TULANG PENDERITA MALARIA M. I. Diah P; Tonang D A; Lusi O W; J. B. Suparyatmo; Yuwono H S
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.914

Abstract

A 26-years-old man, was admitted to the hospital with the symptom of fever for 2 weeks. Differential diagnosis were pneumonia and lung tuberculosis, micrositic hypocromic anemia, and hyperglicemic stress. Bloodlood smear and bone marrow puncture showed infestation puncture showed infestation of Plasmodium falciparum and Plasmodium vivax. In this case, malaria infestation caused pancytopenia. Bone marrow aspiration in. In this case, malaria infestation caused pancytopenia. Bone marrow aspiration in malaria was useful for diagnostic and treatment monitoring.

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