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<![CDATA[Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia ]]>
<![CDATA[Nanang Yunarto]]>;
<![CDATA[Berna Elya]]>;
<![CDATA[Laurentia Konadi]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.2959
<![CDATA[Hyperlipidemia is the main risk factor for atherosclerosis and coronary heart disease. Ethyl acetate fraction of gambier leaves extract (Uncaria gambir Roxb.) contains catechin secondary metabolites which have potency to be used as antihyperlipidemic. This study aimed to examine the antihyperlipidemic effect of ethyl acetate fraction of gambier leaves extract in vivo. Thirty six males of Sprague Dawley strain, 2,5 months old, were randomly divided into six groups: normal group, negative group (distilled water), positive group (simvastatin 2 mg/200 g bw), dose I (5 mg/200 g bw fraction), II (10 mg/200 g bw fraction) and III (20 mg/200 g bw fraction) groups. Rats were induced with high cholesterol and saturated fat feeds for 28 days, except in the normal group. Furthermore, rats were given the treatment for 28 days. The results showed when compared than negative control, dose III reduced of total cholesterol, triglycerides, LDL levels and increased HDL level (p]]>
<![CDATA[Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia ]]>
<![CDATA[Yunarto, Nanang]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.2959
<![CDATA[Hyperlipidemia is the main risk factor for atherosclerosis and coronary heart disease. Ethyl acetate fraction of gambier leaves extract (Uncaria gambir Roxb.) contains catechin secondary metabolites which have potency to be used as antihyperlipidemic. This study aimed to examine the antihyperlipidemic effect of ethyl acetate fraction of gambier leaves extract in vivo. Thirty six males of Sprague Dawley strain, 2,5 months old, were randomly divided into six groups: normal group, negative group (distilled water), positive group (simvastatin 2 mg/200 g bw), dose I (5 mg/200 g bw fraction), II (10 mg/200 g bw fraction) and III (20 mg/200 g bw fraction) groups. Rats were induced with high cholesterol and saturated fat feeds for 28 days, except in the normal group. Furthermore, rats were given the treatment for 28 days. The results showed when compared than negative control, dose III reduced of total cholesterol, triglycerides, LDL levels and increased HDL level (p]]>
<![CDATA[Profil Disolusi Tablet Amlodipin dan Perbandingan Kadar Dua Produk Generik dengan Produk Inovator ]]>
<![CDATA[Sukmayati Alegantina]]>;
<![CDATA[Ani Isnawati]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3029
<![CDATA[Amlodipine is an antihypertensive and antianginal drug belonging to the class of dihydropyridine calcium antagonist (calcium ion antagonist). Amlodipine patent term expired in 2007, thus nowadays some national pharmaceutical manufacturers produce amlodipine as generics and branded generics medicine. In order to determine the quality of generic amlodipine, dissolution profile and contents of two generic amlodipine were studied by comparing them with their innovator product. The dissolution test was carried out using a type 2 (paddle) and the dissolved content was determined by using UV spectrophotometer, whereas amlodipine content tablet was determined by using HPLC (High Performance Liquid Chromatography). The results showed that all of the three tablets met the FDA requirements of dissolution, i.e.within 30 minutes they should be dissolved not less than 85%. All of the three tablets had the same dissolution profile p=0,521 (CI=95%), whereas both the generic and branded generic tablet compared to the innovator product had similar or comparables profile , (f2>50). The content of all three tablets are not significantly different with p=0,08 (CI = 95%). The highest content of amlodipine was found in amlodipine a tablet with an average content of 102,69%.]]>
<![CDATA[Profil Disolusi Tablet Amlodipin dan Perbandingan Kadar Dua Produk Generik dengan Produk Inovator ]]>
<![CDATA[Alegantina, Sukmayati]]>;
<![CDATA[Isnawati, Ani]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3029
<![CDATA[Amlodipine is an antihypertensive and antianginal drug belonging to the class of dihydropyridine calcium antagonist (calcium ion antagonist). Amlodipine patent term expired in 2007, thus nowadays some national pharmaceutical manufacturers produce amlodipine as generics and branded generics medicine. In order to determine the quality of generic amlodipine, dissolution profile and contents of two generic amlodipine were studied by comparing them with their innovator product. The dissolution test was carried out using a type 2 (paddle) and the dissolved content was determined by using UV spectrophotometer, whereas amlodipine content tablet was determined by using HPLC (High Performance Liquid Chromatography). The results showed that all of the three tablets met the FDA requirements of dissolution, i.e.within 30 minutes they should be dissolved not less than 85%. All of the three tablets had the same dissolution profile p=0,521 (CI=95%), whereas both the generic and branded generic tablet compared to the innovator product had similar or comparables profile , (f2>50). The content of all three tablets are not significantly different with p=0,08 (CI = 95%). The highest content of amlodipine was found in amlodipine a tablet with an average content of 102,69%.]]>
<![CDATA[Selektivitas Medium Cystine Tellurite Blood Agar (CTBA) terhadap Beberapa Isolat Bakteri ]]>
<![CDATA[Kambang Sariadji]]>;
<![CDATA[Sunarno Sunarno]]>;
<![CDATA[Nelly Puspandari]]>;
<![CDATA[Fauzul Muna]]>;
<![CDATA[Yuni Rukminiati]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3030
<![CDATA[Cystine tellurite blood agar (CTBA) medium is a selective medium for Corynebacterium diphtheriae culture. The presence of tellurite is a selectivity of this medium to inhibit the others bacteria. Others medium were used as a selective medium for the culture of Corynebacterium diphtheriae were tinsdale and Hoyle medium, but was recommended by the World Health Organization (WHO) were CTBA and hoyle medium. However, information about the selectivity of medium was recommended by WHO is still limited. The aims of study to determine the selectivity of medium against a number of others species bacteria on CTBA. A number of 24 isolates contains of different species Corynebacterium spp and others species were regrown, then all isolates were cultured in CTBA medium, incubated for 24 – 48 haours at 37°C. The growthing of colony in CTBA were observed. The results showed that 7 isolates for Corynebacterium species can grow well on medium CTBA, 5 isolates from different species showed growth in CTBA medium including Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter sakazakii , Klebsiella pneumoniae and Candida albicans. Meanwhile the rest 12 isolates showed no growthing on CTBA medium. Therefore it can be concluded that the selectivity of the CTBA medium has limited capabilities]]>
<![CDATA[Selektivitas Medium Cystine Tellurite Blood Agar (CTBA) terhadap Beberapa Isolat Bakteri ]]>
<![CDATA[Sariadji, Kambang]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3030
<![CDATA[Cystine tellurite blood agar (CTBA) medium is a selective medium for Corynebacterium diphtheriae culture. The presence of tellurite is a selectivity of this medium to inhibit the others bacteria. Others medium were used as a selective medium for the culture of Corynebacterium diphtheriae were tinsdale and Hoyle medium, but was recommended by the World Health Organization (WHO) were CTBA and hoyle medium. However, information about the selectivity of medium was recommended by WHO is still limited. The aims of study to determine the selectivity of medium against a number of others species bacteria on CTBA. A number of 24 isolates contains of different species Corynebacterium spp and others species were regrown, then all isolates were cultured in CTBA medium, incubated for 24 – 48 haours at 37°C. The growthing of colony in CTBA were observed. The results showed that 7 isolates for Corynebacterium species can grow well on medium CTBA, 5 isolates from different species showed growth in CTBA medium including Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter sakazakii , Klebsiella pneumoniae and Candida albicans. Meanwhile the rest 12 isolates showed no growthing on CTBA medium. Therefore it can be concluded that the selectivity of the CTBA medium has limited capabilities]]>
<![CDATA[Studi Docking Molekuler Catechin Gallate, Epicatechin Gallate, Gallocatechin Gallate, dan Epigallocatechin Gallate ]]>
<![CDATA[Ani Isnawati]]>;
<![CDATA[Rosa Adelina]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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<![CDATA[Indonesia has the second biggest natural in the world. This natural resources could be used as raw material for drug if well managed. As we know, 96% of raw material in Indonesia are imported which caused the price of drugs are expensive. In order to overcome the problem, it is essential to conduct research about Indonesian plants which are potential as dyslipidemia drug. The molecular docking study is one of insilico studies that is used to screen compounds based on their working mechanism to protein. In this study, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were docked using Moleculer Operating Environtment (MOE). Software in order to determine their affinity and interaction with HMG-CoA reductase enzyme which has a role in cholesterol/fat metabolism. This research used simvastatin and atorvastatin as the standard drug for dyslipidemia. The result of molecular docking showed that Gibbs values of simvastatin, atorvastatin, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were -6,4974; -8,543; -9,5736; -10,6395; -10,4765; and -10,598. The results stated that four cathechin derivates have an inhibiting energy better than simvastatin and atorvastatin. These are potential as dyslipidemia drugs candidate.]]>
<![CDATA[Studi Docking Molekuler Catechin Gallate, Epicatechin Gallate, Gallocatechin Gallate, dan Epigallocatechin Gallate ]]>
<![CDATA[Isnawati, Ani]]>;
<![CDATA[Adelina, Rosa]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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<![CDATA[Indonesia has the second biggest natural in the world. This natural resources could be used as raw material for drug if well managed. As we know, 96% of raw material in Indonesia are imported which caused the price of drugs are expensive. In order to overcome the problem, it is essential to conduct research about Indonesian plants which are potential as dyslipidemia drug. The molecular docking study is one of insilico studies that is used to screen compounds based on their working mechanism to protein. In this study, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were docked using Moleculer Operating Environtment (MOE). Software in order to determine their affinity and interaction with HMG-CoA reductase enzyme which has a role in cholesterol/fat metabolism. This research used simvastatin and atorvastatin as the standard drug for dyslipidemia. The result of molecular docking showed that Gibbs values of simvastatin, atorvastatin, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were -6,4974; -8,543; -9,5736; -10,6395; -10,4765; and -10,598. The results stated that four cathechin derivates have an inhibiting energy better than simvastatin and atorvastatin. These are potential as dyslipidemia drugs candidate.]]>
<![CDATA[The Preparedness of Pharmacist in Community Setting to Cope with Globalization Impact ]]>
<![CDATA[Max Joseph Herman]]>;
<![CDATA[Rini Sasanti Handayani]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3471
<![CDATA[A descriptive study to identify the preparedness of pharmacist in community pharmacies to cope with globalization impact was conducted in 2009. This cross-sectional study was done in DKI Jakarta, Bali and Maluku. Informants were purposively determined involving pharmacists from schools of pharmacy, Indonesian Pharmacist Association (IAI), community pharmacies, Provincial and District Health Offices, as well as comunity pharmacy owners. Primary data were collected through in-depth interviews and observation using check-list in community pharmacy. Data were analyzed descriptively and qualitatively using triangulation method. Results of the study show that according to Health Offices and the Indonesian Pharmacist Association, pharmacists were not adequately prepared and pharmacists in stand alone community pharmacy are less prepared than those in a network or franchise pharmacy. Licensed pharmacists of network community pharmacy in the metropolis are going to prepare themselves to face the new patient-oriented paradigm and to meet the standard of pharmacy service, whereas stand-alone community pharmacy still prioritized fast service and lower drug price]]>
<![CDATA[The Preparedness of Pharmacist in Community Setting to Cope with Globalization Impact ]]>
<![CDATA[Herman, Max Joseph]]>;
<![CDATA[Handayani, Rini Sasanti]]>
<![CDATA[ Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015 ]]>
Publisher : <![CDATA[Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan ]]>
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DOI: 10.22435/jki.v5i1.3471
<![CDATA[A descriptive study to identify the preparedness of pharmacist in community pharmacies to cope with globalization impact was conducted in 2009. This cross-sectional study was done in DKI Jakarta, Bali and Maluku. Informants were purposively determined involving pharmacists from schools of pharmacy, Indonesian Pharmacist Association (IAI), community pharmacies, Provincial and District Health Offices, as well as comunity pharmacy owners. Primary data were collected through in-depth interviews and observation using check-list in community pharmacy. Data were analyzed descriptively and qualitatively using triangulation method. Results of the study show that according to Health Offices and the Indonesian Pharmacist Association, pharmacists were not adequately prepared and pharmacists in stand alone community pharmacy are less prepared than those in a network or franchise pharmacy. Licensed pharmacists of network community pharmacy in the metropolis are going to prepare themselves to face the new patient-oriented paradigm and to meet the standard of pharmacy service, whereas stand-alone community pharmacy still prioritized fast service and lower drug price]]>
