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Contact Name
Nanang Yunarto
Contact Email
nayunandesba@yahoo.com
Phone
+628156867400
Journal Mail Official
jurnalkefarmasian@gmail.com
Editorial Address
Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI Jl . Percetakan Negara No. 23 – JAKARTA 10560
Location
Kota adm. jakarta pusat,
Dki jakarta
INDONESIA
Jurnal Kefarmasian Indonesia
ISSN : 2085675X     EISSN : 23548770     DOI : https://doi.org/10.22435/jki.v9i1
Core Subject : Health,
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care
Articles 219 Documents
Ekstrak Daun Annona muricata Linn. sebagai Antiproliferasi terhadap Sel Hepar Tikus Terinduksi 7,12 Dimetilbenz [a] antracene (DMBA) Rosa Adelina; Rahmi Febriyanti; Intan Sari Oktoberia; Putri Reno Intan
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1448.482 KB) | DOI: 10.22435/jki.v4i1.2896

Abstract

Annona muricata Linn. atau sirsak yang mengandung senyawa golongan acetogenin mampu menginduksi apoptosis pada secara in vitro dan bersifat sitotoksik. Telah dilakukan penelitian untuk membuktikan potensi ekstrak daun sirsak secara in vivo dalam menghambat perkembangan tumor hepar akibat induksi senyawa kimia 7,12 dimetilbenz [a] antracene (DMBA). Induksi dilakukan selama dua kali seminggu selama lima minggu, pada hewan coba tikus putih (Rattus novergicus) strain Sprague Dawley. Ekstrak daun sirsak diberikan dengan tiga peringkat dosis, yaitu 200, 400, dan 800 mg/kg BB, selama tujuh belas hari setelah dua minggu pemberian DMBA. Hasil pemeriksaan histopatologi dan penentuan aktivitas proliferasi sel hepar dengan AgNOR menunjukkan adanya penurunan aktivitas proliferasi sel hepar secara signifikan. Disimpulkan bahwa ekstrak daun sirsak berpotensi sebagai antiproliferasi pada tumor hepar secara in vivo.
Kualitas Minyak Goreng Habis Pakai Ditinjau dari Bilangan Peroksida, Bilangan Asam dan Kadar Air Asri Sulistijowati Suroso
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

There are habits to reuse cooking oil that for main reason of cost saving. Reusing cooking oil might be problem for health.This research aimed to study the number of peroxide number, acid value, free fatty acid, and water content of light and dark brown reused cooking oil. The quality of oil were compared to The National Standard of Indonesia (SNI 01-3741-2002) Edible Oil Quality. Peroxide number was determined by iodometric methods, free fatty acid level and acid value by alkali titration (KOH/NaOH), and water content by gravimetric methods. The oil sample were light and dark brown reused cooking oil and new packaged oil. The oil that, use as standard reference, was new packaged oil. Each oil was analyzed three times. Reuse cooking oil was got from food vendor in Bogor. The results showed that the mean of peroxide number, acid value, free fatty acid level and water content of the black colour of reused cooking oil were 7.89 O2/100g; 1.46 mg KOH/g; 0.64% and 0.61% w/w respectively. The brown colour oil were 5.15 O2/100g; 0.94 mg KOH/g; 0.41% and 0.79% w/w respectively. These light and dark brown reused cooking oils did not comply with SNI 01-3741-2002, therefore they are not suitable to be used for cooking.
Peranan Pharmaceutical Care dalam Meningkatkan Hasil Klinis dan Kualitas Hidup Pasien Penderita Diabetes Melitus Muhammad Syaripuddin
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Pharmaceutical care is patient oriented pharmacy practice that required other healthcare to optimize drug therapy. In the management of diabetes mellitus indicators was established as a target in pharmaceutical care. The purpose of this paper is to evaluate pharmaceutical care program, in order to optimize clinical result and quality of life of the patient diabetes mellitus, and to identify indicators in pharmaceutical care program for patient diabetes mellitus as well. Research of the impact of pharmaceutical care program for diabetes mellitus patient have been done in other countries. The results showed that diabetes mellitus indicators in patients managed with pharmaceutical care program were better than those without that program applied. All patients with intervention of pharmaceutical care program can control clinical result such as blood glucose, blood presure, level of HbA1C, HDL, LDL and total cholesterol. The patient’s quality of life with intervention had improved compare to those without intervention. Indicators to evaluate pharmaceutical care program have changed from clinical indicators only to clinical plus quality of life indicators. Pharmaceutical care program was useful to improve clinical result and quality of life of diabetic patient. Quality of life indicators could be added to evaluate pharmaceutical care program. Pharmaceutical care program brings about positif impact for patient, provider, pharmacist and economic aspect as well.
Prospek Tanaman Obat sebagai Antihepatitis Nanang Yunarto
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hepatitis remains a serious global health problem because of the potential impact to morbidity and mortality. Prevalence of hepatitis patients in Indonesia either by viral infection or noninfection increases rapidly. The high cost of treatment hepatitis resulted in the switch in the use medicinal plants to cope with this disease. Several types of medicinal plants were proven to be antihepatitis such as meniran, temulawak, mengkudu and pegagan. The objective of this paper is to provide scientific information study of medicinal plants useful as antihepatitis and their development prospect. The method used in this study is to review the relevant scientific articles in international and national journals. Based on reference studies it has been reported that meniran, temulawak, mengkudu and pegagan have a great potential and prospective as antihepatitis drugs. The important challenge in development of medicinal plants is a constant quality as well as, continuous supply of raw materials and effect assured.
Karakterisasi dan Sifat Fisik Sistem Koaservasi Gelatin - Gum Akasia Komari Komari
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Complex coacervation system of gelatin solution of 1% and acacia gum of 1% could be developed for encapsulation of bio-active materials. The system had been developed to measured optimum pH of coacervate formation, coaservate recovery, viscosity and density of the solution sistem for predicting its membran thickness on covering the bio-active materials. Results showed that using turbidity measurement, pH of the system could recovery of the coacervate of the sistem was 3,5 and the dried coacervate recoveri was 81±4%. The mixture of gelatin solution of 1% and gum acacia solution of 1% were measured for density and viscosity and the results were 1,0876 ± 0,0045 g/ml and 0,986±0,025 mPa.s, respectively. This physical characteristics could be used for calculating membran thickness for certain bio-active material to be coated
Stabilitas Imunoglobulin M (IgM) Campak pada Dried Serum Spots Kartika Dewi Puspa; Mursinah Mursinah; Ratumas Rosmawati Budianto
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Shipping and storage of measles serum specimens from fields to the reference laboratory must consider the cold chain in order to maintain the stability of immunoglobulin M (IgM) in serum. Meanwhile, to maintain the cold chain needs special handling. This study aimed to determine the use of filter paper as an alternative in shipping and storage of specimens. This experimental study used measles positive serum received at the National Measles Laboratory Center for Biomedical and Basic Technology of Health from January until March 2011. There were three groups of sample. Each group consisted of 9 specimens. The effects of temperature and storage period on the stability of measles IgM of dried serum spots (DSS) stored in 4ºC and 25ºC for one, three, six, nine, twelve, and five teen days were tested at the National Measles Laboratory Center for Biomedical and Basic Technology of Health from July until December 2011. The stability of measles IgM of DSS that were stored at 4ºC and 25ºC temperature showed no significant difference (p = 0.316) compared to the serums stored at a temperature of 4ºC in the measurements on the third day. Dried serum spots can not be used as sample alternative for detection of measles virus-spesific immunoglobulin M
Uji Mutagenik Ames untuk Melengkapi Data Keamanan Ekstrak Gambir (Uncaria gambir Roxb.) Novi Sulistyaningrum; Sukmayati Alegantina; Lina Rustanti
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

The main compound of Uncaria gambir Roxb. (gambir), catechin and it’s derivates have been believed to be potential as antiviral. Epigallocatechin gallate (EGCG) and epicatechin are catechin derivates which are found to be potential as antiviral against Human Immunodeficiency Virus (HIV). However, gambir extract also contains quercetin that has possibility to be mutagenic. Therefore, a preliminary study towards safety of those compounds within gambir extract, mutagenicity assay using Ames Method has been performed.Sample (gambir extract) was obtained from West Sumatera, Indonesia. The extract was characterized according to Farmakope Herbal Indonesia and WHO methods. Mutagenicity test by Ames method utilized a colorimetric microplate in 6 various concentration (125 mg/mL; 62.5 mg/mL; 31.25 mg/mL; 15.625 mg/mL; 7.81 mg/mL dan 3.91 mg/mL) against mutant bacteria Salmonella typhimurium TA 98, Salmonella typhimurium TA 100 and Escherichia coli WP2 uvrA with and without the addition of S-9 enzyme. Extract of gambir in this study contains 86.60% of catechin, 12.92% moisture content, 22.49% water-soluble extract content, 80.63% ethanol-soluble extract content, 0.81% total ash, 0.32% acid insoluble ash content and 10.38% in dryness level. From the mutagenicity test and calculation, fold increase (over baseline) of the sample in 6 various concentration with and without adding S-9 enzyme are lower than 2. Gambir extract from West Sumatra with catechin contains 86.6% hasn’t showed mutagenic effect due to the fold increase (over baseline) of mutagenicity test lower than 2.
Pelayanan Farmasi dan Perbekalan Kesehatan pada Musim Haji Tahun 2012 di Sektor 3 Madinah, Arab Saudi Winarsih Winarsih; Daroham Mutiatikum
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Service activities of Indonesian pilgrims in Madina, Saudi Arabia, which took place during the period September - November in 2012 consisted of two stages of the pre and the post Armina. In this study gives an overview of the implementation of services to the pharmaceutical and health supplies in sector 3 Madina. It also wants to know the availability of the drugs on sector 3 Madina and determine the amount of drug use ever. The design was a cross sectional study in which after processing the data it is known that there is a need for a drug that different during the two periods is both the number and types of medicines. But overall medicine and health supplies needs sector 3 Madinah can be met properly.
Kajian Tanaman Obat Indonesia yang Berpotensi sebagai Antidepresan Rosa Adelina
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Depression as a mental illness has many negative effects to people’s quality of life. The synthetic drugs has been developed to cure this illness but the side effect has compromized the therapy. Other side, the use of herbal medicine has been accepted in almost country in the world.The objective of this study is to find antidepressant drug from Indonesian herbal medicine. The study is an assessment derived from 53 publications of antidepressant effect of Indonesian herbal from national and international papers.The assessment include the active compounds, mechanism, and used part of plant. The result of this study is there are nine potential Indonesian plants to be a co-therapy or alternative drug as antidepressant. They are Valeriana javanica, Areca catechu Linn, Piper longumBl., Curcuma longaLinn, Momordica charantia Linn, Clitoria ternatea, Morinda citrifolia, Myristica fragrans, and Ocimum basilicum
Kualitas Ekstrak Etanol 70% Daun Kelor (Moringa oleifera Lamk) dalam Ramuan Penambah ASI Sukmayati Alegantina; Ani Isnawati; Lucie Widowati
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 1, FEBRUARI 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

From the collection of data (SDKI) in 2002-2003, it is found that the number of exclusive breastfeeding in infants below the age of two months covers only 64% of total infants. The most alarming facts are that 13% of infants under two months have been fed infant milk formula and one of three infants aged 2-3 months has been given additional food. Therefore, using Kelor as herba to facilitating breast milk is needed as extract requirement. In addition, this research considers characterization of Kelor extract as a first step to standardize Kelor extract. Sample is extract of Kelor leaf from East Java. To ensure quality requirements of 70% ethanol extract from Kelor leaf for herbal medicine, it has to meet the quality requirement guidelines established by BPOM. Examination includes non-specific parameter such as water content, total ash, total acid insoluble ash, and extract microscopic examination. In the other side, specific parameter includes content of dilute alkohol, content of dilute water, assay of total alkaloid and chemistry compound test. Characteristic of 70 % ethanol extract from Kelor leaf for non-specific parameter are water content 15,68%, total ash 3,04%, total acid insoluble ash 1,13% and loss on drying 29,70% , whereas characteristic of spesific parameter for content of dilute etanol 33,11%, content of dilute water 47,53%, and assay Trigonellin 15,68 %. The conclusion is non spesific characteristic from kelor leaf etanol extract, that is water content does not meet the quality requirement guidelines

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