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Jurnal Ilmiah Medicamento
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 23564814     DOI : https://doi.org/10.36733/medicamento.v6i1
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Medicamento (JINTO) dengan nomor registrasi e-ISSN 2356-4814 didirikan pada tahun 2014, dan publikasi online dimulai pada tahun 2015. Jurnal diterbitkan dalam bahasa Indonesia. Awalnya JINTO diterbitkan oleh Akademi Farmasi Saraswati Denpasar. Namun sejak awal tahun 2019, penerbit jurnal berubah menjadi Fakultas Farmasi Universitas Mahasaraswati Denpasar karena institusi penerbit sebelumnya yaitu Akademi Farmasi Saraswati Denpasar telah mengalami penyatuan ke dalam institusi Universitas Mahasaraswati Denpasar menjadi Fakultas Farmasi. Jurnal Ilmiah Medicamento diterbitkan setiap enam bulan sekali (Maret dan September) yang berisi penelitian di bidang ilmu farmasi. JINTO menerima artikel yang mencakup berbagai bidang ilmu farmasi seperti: Farmakologi dan Toksikologi; Farmasi Klinik dan Komunitas; Kimia Farmasi; Biologi Farmasi; Teknologi Farmasi; Farmasi Mikrobiologi dan Bioteknologi; Regulatory Affairs and Pharmacy Marketing Research; Pengobatan alternatif.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
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Search results for , issue "Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento" : 9 Documents clear
Evaluasi Efek Samping Penggunaan Obat Kombinasi Metformin dan Glimepiride pada Pasien Diabetes Melitus Tipe 2 Ni Nyoman Wahyu Udayani; I Gusti Agung Ayu Kusuma Wardani; I Dewa Ayu Anom Yustari Nida
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3164

Abstract

The combination of metformin and glimepiride can significantly reduce fasting blood glucose, post prandial blood glucose, and HbA1c levels. Side effects that often occur in the use of metformin are gastrointestinal disturbances. This study aims to determine the side effects of using a combination of metformin and glimepiride in outpatient type 2 diabetes mellitus at a hospital in Gianyar. This research is an observational research and data collection is done with a cross sectional approach and analyzed using descriptive methods. Data was taken by looking at the patient's medical record, including name, medical record number, gender, age, drugs given, patient diagnosis, and patient complaints during therapy. Sampling used purposive sampling technique with a total of 70 patients who entered the inclusion criteria. The results show that the number of women (62.86%). The most age range suffering from type 2 diabetes mellitus is 56-65 years (52.86%). The highest percentage of people with type 2 diabetes mellitus had a basic education level (40.00%). The side effects obtained from the combination of metformin and glimepiride in patients with type 2 diabetes mellitus at the hospital were nausea and vomiting (31.43%), flatulence (25.71%), fatigue (17.14%), headache (15.72%), and hypoglycemia (10.00%).
Pengaruh Glimepirid terhadap Penurunan Glukosa Darah pada Mencit Diabetes-Disfungsi Ginjal Lili Sartika; Ikha Rahardiantini
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3517

Abstract

Diabetes mellitus (DM) is a disease or chronic metabolic disorder that can cause long-term complications such as damage to the liver, heart, eyes, and kidneys. One of the diabetes drugs is glimepiride. Glimepiride has the main mechanism of action of lowering blood glucose by stimulating insulin secretion from the granules of Langerhans cells. This study aims to determine the effect of glimepiride on reducing blood glucose in diabetic-kidney dysfunction mice. The design of this research is Post-test Only Control Group Design. This study used 105 mice which were divided into 7 groups. The dose of glimepiride was made in three variations: 1 mg/kgBW, 2 mg/kgBW and 4 mg/kgBW. The results showed no significant effect on decreasing blood glucose levels in diabetic-kidney dysfunction mice at various doses of glimepiride (p>0.05). Furthermore, further tests were carried out which showed that there was a significant effect on the duration of administration of various doses of glimepiride in reducing blood glucose levels in diabetic-kidney dysfunction mice (p<0.05). From the results of this study, it can be concluded that the pathology of the disease does not significantly affect the mechanism of action of glimepiride. Still, the length of time glimepiride is administered to diabetic-renal dysfunction mice shows a significant effect.
Pengaruh Bentuk Sediaan terhadap Potensi Antioksidan Ekstrak Etanol Daun Sirsak (Annona muricata L.) dalam Sistem Nanopartikel Malinda Prihantini; Nopbrillian Fine Setya; Anisa Rizki Amelia; Tsabita Udkhiya Zulfa
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3699

Abstract

Flavonoids in soursop leaf ethanol extract have various pharmacological effects but are easily degraded due to the influence of pH, oxygen, and intense light exposure. Encapsulation using chitosan polymer in nanoparticles is able to overcome these limitations. The formulation of the nanoparticle system in lotion and cream preparations can increase the comfort of use by consumers. Therefore, this study was conducted to determine the effect of lotion and cream dosage forms on the antioxidant activity of soursop leaf ethanol extract nanoparticles. Soursop leaf extraction was done by soaking at room temperature for 3 days using 70% ethanol as solvent. The soursop leaf ethanol extract nanoparticle system was prepared with three graded Soursop leaf ethanol extract concentrations F1 100 mg, F2 200 mg, and F3 300 mg. The nanoparticle system is then formulated into lotion and cream preparations. Evaluation of antioxidant activity was carried out by reacting it with DPPH, and the IC50 value of lotion preparation was obtained and showed the result was (F1) 83,34±0,130; (F2) 74,69±0,131; and (F3) 64,26±0,129 ppm, while the IC50 value of cream was (F1) 84,32±0,133; (F2) 75,35±0,130; and (F3) 63,74±0,120  ppm. The antioxidant activity of soursop leaf ethanol extract nanoparticles in lotion and cream preparations is included in the category of strong antioxidants. Statistical analysis using an independent t-test of the antioxidant activity showed p>0.05, so it was concluded that the ability to scavenge free radicals from soursop leaf ethanol extract in the nanoparticle system was not affected by the dosage form.
Pengaruh Media Edukasi terhadap Pengetahuan Siswa Sekolah Dasar tentang Pencegahan Covid-19 Novita Ayu Wardhany; Yeni Farida; Rasmaya Niruri
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3723

Abstract

Covid-19 is a highly transmittable disease caused by viral infection. Children belong to the age group vulnerable to the transmission of COVID-19. Health promotion is important to provide a basic understanding of minimizing the incidence of transmission. The success of health promotion is influenced by the methods and media used. Comic and animation videos are considered capable of helping students in the learning process. This study was conducted to determine the level of knowledge of respondents who were given education through comics and animation media and to find out the difference in knowledge between the two media. Experimental pre-test and post-test designs were conducted. The educational media used are comics and animation videos. The research subjects were 5th-grade students of SDIT Insan Mulia Surakarta. Knowledge is assessed from the ability to answer questions correctly based on the educational material provided. The Wilcoxon test analysis was used to determine the differences in respondents' knowledge before and after giving the media and the Mann-Whitney test to determine the differences in respondents' knowledge between media. The results of the research on 42 respondents showed an increase in the pre-test and post-test scores in both groups. The mean pretest and post-test scores of the comic group were 7.86 and 9.17, while the mean score in the video animation group were 7, 89, and 8.68. Wilcoxon test result p-value of 0.001 in the comic media group and 0.004 in the animation media group. This study showed that there was no significant difference in knowledge of comics and animation group (p-value 0.200; P> 0.05). These results showed that both media have the same effectiveness in increasing respondents' knowledge of Covid-19 prevention.
Essential Oil of Alpinia galanga: Effect of Aromatherapy Inhalation in Mice and Physicochemical Characterization Ni Made Dwi Mara Widyani Nayaka; Ni Luh Putu Swari; Putu Era Sandhi Kusuma Yuda; I Gusti Ayu Agung Kusuma Wardani
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3791

Abstract

Aromatherapy has been used for centuries to maintain body and mental health. In aromatherapy, the inhalation of essential oil provides physical and psychological benefit due to its volatile bioactive compounds. The current study was aimed to determine the effect of the inhalation of Alpinia galanga essential oil in mice using forced swim test. The refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) profile of AGEO were also investigated. The essential oil from Alpinia galanga showed an anti-depressive-like effect and it was as strong as the positive control (Lavandula angustifolia essential oil). The GC-MS analysis discovered some antidepressant compounds in the oil such as eucalyptol, fenchone, and α-terpineol.
Kajian in silico Penghambatan Spesifik 3C-like Protease SARS-CoV-2 Senyawa Quinic Acid, Gluconic Acid, dan Ferulic Acid pada Kulit Kopi Yohanes Bare; Frederiksen Novenrius Sini Timba; Dewi Ratih Tirto Sari; Oktavius Yoseph Tuta Mago; Maria Marcelina Dua Nurak
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.3971

Abstract

This study aims to explore the chemical compounds of the coffee pulp as an anti-covid-19 (anti-3C-like protease). In silico modeling was carried out by structure retrieval, protein preparation, and docking simulation. Specific Grid docking was used for ligands – protein interacting by using Molegro Virtual Docker 5, followed by visualizing Discovery studio version 21.1.1. Compounds contained in coffee pulp, quinic acid, gluconic acid, and ferulic acid separately bind to the same amino acid residues of 3CL Protease or each other. Furthermore, three compounds inhibited 3CLPro activity by catalytic site blocking of 3CLPro, indicating that coffee compounds have potential as molecular therapeutic materials for the coronavirus by inhibiting SARS-CoV-2 genome replication.
Hubungan Peran Tenaga Kefarmasian dan Dukungan Keluarga dengan Tingkat Kepatuhan Minum Obat Antihipertensi di Apotek “X” Kota Denpasar Ni Putu Wintariani; Dewi Puspita Apsari; Ni Putu Aryanti Suryaningsih; I Putu Tangkas Suwantara; Fitria Megawati
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.4076

Abstract

Hypertension is a condition where a person's blood pressure is above normal, which is 140 mmHg systolic or 90 mmHg diastolic. Hypertension causes increased morbidity, with almost the same prevalence in developing and developed countries. In terms of medication adherence, patient awareness of treatment plays an important role. The role of family members in adherence to taking hypertension medication is very important. Support and attention from the family is one of the supporting factors, the success of hypertension treatment, so it is expected to reduce the mortality rate. Clinical pharmacy services in pharmacies are part of pharmaceutical services that are directly responsible for patients involved in dispensing. In this study, researchers tried to understand the relationship between the role of family support and the role of pharmacists in taking high blood pressure drugs at the "X" Denpasar Pharmacy. The results obtained in this study are that there is a significant and strong relationship between family support and adherence to taking antihypertensive medication in the domain of emotional support and rewards (p=0.000; r=0.75) and instrumental support (p=0.003; r=0, 52). The role of pharmacists on compliance has a strong and significant effect (p = 0.002; r = 0.64).
Studi Literatur Profil Farmakokinetik dan Penetrasi Antibiotik ke Jaringan Ulkus Diabetik Munifah Wahyuddin; Dwi Wahyuni Leboe; Khaerani Khaerani; Nurshalati Tahar; Alifia Putri Febriyanti; Nursyamsi Dhuha; Yuliani Yuliani
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.4153

Abstract

A diabetic foot ulcer is a complication of diabetes that causes open sores that can develop into an infection. The selection of the right antibiotics is based on the pharmacokinetic profile of antibiotics that can show antibiotic activity as bactericidal or bacteriostatic, the main bacteria found in diabetic ulcer disease are gram-positive bacteria such as Methicillin-Resistant Staphylococcus aureus (MRSa). This study aims to determine the antibiotics acting on diabetic ulcer tissue and the pharmacokinetic profile and penetration of antibiotics into diabetic ulcer tissue based on a literature study using the PICO (patient/population, intervention, comparison, and outcomes) method. The results of the analysis of 8 articles that met the inclusion criteria showed that the pharmacokinetic profile (PK) of several antibiotics obtained showed bactericidal activity in the treatment of diabetic ulcers including the antibiotics ceftolozane/tazobactam, tedizolid, cefepime, daptomycin, trimethoprim/sulfamethoxazole. Several antibiotics have shown activity as bacteriostatic in the treatment of diabetic ulcers, including linezolid antibiotics and vancomycin antibiotics.
Pengaruh Ekstrak Etanol Daun Pangi (Pangium edule) terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus novergicus) Galur Wistar I Made Agus Sunadi Putra; Ni Ketut Era Erliana
Jurnal Ilmiah Medicamento Vol 8 No 2 (2022): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v8i2.5167

Abstract

Burns is a form of tissue damage caused by contact with sources that have high temperatures such as fire, electricity, and chemicals. Pangi leaves contain chemical flavonoids, alkaloids, sponges, tannins, and terpenoids that can be used as an alternative in the treatment of burns. This study aims to determine the effect of ethanol extract from Pangi leaves on the healing of second-degree burns. The research design used was an experimental method using white rats with Wistar strain as experimental animals. The treatments were made of 4 kinds with 6 repetitions each. Pangi leaf extraction was carried out by maceration method with 95% ethanol. Variations in treatment were positive control using silver sulfadiazine ointment, negative control without treatment, 2.5% ethanol extract of Pangi leaves and 5% ethanol extract of Pangi leaves. Burns were made by using an iron plate heated with Bunsen fire for 2 minutes and then affixed to the back of the rat for 5 seconds until a second burn was formed which was marked by a reddish color and there were bubbles filled with fluid in the wound. Observations were made by looking at and measuring the width of the wound on day 1, day 2, day 4, and day 7. The results showed that the ethanol extract of Pangi leaves accelerated the healing process of second-degree burns in white rats with the Wistar strain. Pangi leaf ethanol extract with a concentration of 5% was more effective than the concentration of 2.5%. It can be concluded that the ethanolic extract of Pangi leaves affects the speed of wound healing in white rats of the Wistar strain and can be considered one of the active ingredients for the treatment of burns.

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