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Yudi Her Oktaviono
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Cardiovascular and Cardiometabolic Journal (CCJ)
Published by Universitas Airlangga
ISSN : 27466930     EISSN : 27223582     DOI : 10.20473/ccj.v1i2.2020.31-37
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology
- Adult cardiac surgery - Atherosclerosis - Cardiac imaging - Cardiac prevention - Cardiac rehabilitation - Cardiomyopathy - Cardiovascular immunology and infection - Congenital heart disease - Diabetes mellitus - Dyslipidaemia - Electrophysiological heart disease and arrhythmias - Extracorporeal circulation and cardiac perfusion - Heart failure - Hypertension and hypertensive heart disease - Ischaemic heart disease and coronary artery disease - Metabolic disorders and its linked to cardiovascular diseases - Pediatric cardiac surgery - Pericarditis and pericardial disease - Reactive oxygen species - Rheumatic valvular disease - Vascular disease
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 54 Documents
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A Patient with Acute Myocardial Infarction who Experienced Mortality due to Ventricular Septal Rupture: A Case Report Romi Ermawan
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.46-51

Abstract

Ventricular septal rupture (VSR) is one of the rare complications of acute myocardial infarction (AMI). Although the incidence decreased in percutaneous coronary intervention (PCI) era, the mortality rate remained extremely high. We report a case of an AMI patient who developed a post-fibrinolytic VSR, which was confirmed by echocardiography. Although rescue PCI had been performed, the clinical condition did not improve because he was also having coronary slow flow (CSF). Then he fell into cardiogenic shock and acute lung edema, and died. The main key to dealing with VSR is to reduce afterload so that the left-to-right bypass flow can be reduced in order to maintain the adequate LV stroke volume. In addition to pharmacological therapy, mechanical supportive therapy and correction of VSR both surgically or transcatheterly are required. However, AMI patients with VSR still have a poor prognosis even with the optimal treatment. Keywords: Acute myocardial infarction, Mortality, Ventricular Septal Rupture
Dapagliflozin Use in Heart Failure with Reduced Ejection Fraction Accompanied by Type 2 Diabetes Mellitus: A Systematic Review Sinta Dwi Juniar; Mochamad Yusuf Alsagaff; Budi Susetyo Pikir; Pudji Lestari
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.60-74

Abstract

Abstract: Heart failure patients with reduced ejection fraction (HFrEF) respond well to pharmacological therapy and show a better prognosis. Heart failure patients with reduced ejection fraction and type 2 diabetes who were given SGLT-2 inhibitor therapy showed a strong and consistent reduction in the risk of death and hospitalization. The therapy that has recently begun to be investigated for its benefits for heart failure from the SGLT-2 inhibitor class is Dapagliflozin. The systematic review aims to analyze the effect of Dapagliflozin on the prognosis of HFrEF patients with type 2 diabetes mellitus. Material and Methods: The literature was searched from e-database PubMed, ScienceDirect, and ClinicalTrial.gov. Quality assessment was done using the Critical Appraisal Skills Program (CASP) Randomized Controlled Trial Standard Checklist. Results: A total of 22,167 patients from 4 RCTs eligible studies were included. The analysis results of all of the included studies indicate that Dapagliflozin affected the patient's prognosis. Two studies discuss mortality and hospitalization, and two studies discuss symptoms, functional status, and Quality of Life (QoL). Conclusion: Dapagliflozin can improve the prognosis of HFrEF patients with type 2 DM. The improved prognosis includes reduced mortality, reduced hospitalizations by minimizing disease worsening, reducing symptoms, improving functional status and QoL. Keyword: Cardiovascular disease, Dapagliflozin, Diabetes, Prognosis, SGLT 2 inhibitor
Quality of Life in Children with Acyanotic Congenital Heart Disease in Dr. Soetomo General Hospital, Surabaya, Indonesia Salsabila Fabianca Alsaid; Taufiq Hidayat; Heroe Soebroto
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.1-8

Abstract

Abstract: Acyanotic congenital heart disease is a disease that affects the patient physically and psychologically result in the patient not being able to carry out his life normally. As a result, patients will feel lonely, rejected, and isolated from society which makes social integration more difficult. The picture of quality of life in acyanotic CHD patients can be used as a therapeutic evaluation material to improve quality of life. Material and Methods: This study used descriptive analytic method with total sampling. The variable studied was quality of life using Pedsql Inventory 3.0 Cardiac Module questionnaire to the patients aged 2-18 years who were treated at Dr. Soetomo General Hospital Surabaya in 2019—2020. Results: 74 Acyanotic CHD patients (left to right shunt) obtained an average quality of life of 73.89 ± 9.79 with low-value aspects, namely Heart Problems and Therapy I (72.92 ± 18.20), Cognitive (59.53 ± 18.40), and Communication (71.40 ± 24.21). There was a significant difference in the type of combination diagnosis compared with other types with a significance of 0.014 (p <0.05). Conclusion: Aspects that have a negative impact on the patient's quality of life are Heart Problems and Therapy I, Cognitive, and Communication. The Combination type is a diagnosis with the lowest quality of life compared to other types. Keywords: Acyanotic CHD, PedsQL, Quality of life
Identification of The Effect of Hyberbaric Oxygen Therapy (HBOT) on Blood Pressure Lowering Effects in Hypertension Patients Karindra Amadea Susetiyo; Agus Subagjo; Primadita Syahbani; Iqlima Rahmawati; Ikhsanuddin Qothi
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.52-59

Abstract

Hypertension is a leading cause of death worldwide including in Indonesia. The World Health Organization (WHO) estimates that currently the global prevalence of hypertension is 22% (WHO, 2019). In 2018 the prevalence of hypertension in Indonesia reached 34,11% (Riskesdas, 2018). Every year, it is estimated that 10.4 million deaths are caused by hypertension (Unger et al., 2020). Hyperbaric Oxygen Therapy (HBOT) is a therapy with pure oxygen concentration (100%) in a high pressure room (Ortega et al., 2021). In previous studies it was found that HBOT improves the effects of vasodilation (Mihaljevic et al., 2018). However, other studies mention different results. It was found that HBOT initiates vasoconstriction and increases systemic vascular resistance. This causes a decrease in nitrite oxide (NO) production and increase NO oxidation (Goyal et al., 2021). Apart from a variety of different study results, the use of HBOT has indeed been widely studied even though it has not found a clear meeting point on the effects of blood pressure reduction on hypertension patients. Therefore, the author aims to find out more clearly the mechanism and benefits of hyperbaric oxygen therapy against decreased blood pressure in hypertension patients.           Keywords: Hyperbaric Oxygen Therapy, Hypertension
Correlation between Age and Defect Size with Increased Pulmonary Arterial Pressure in Adult Atrial Septal Defect (ASD) Patients at Cardiology and Vascular Medicine Department dr. Seotomo Public Hospital Surabaya 2019-2021 Astrid Aulia Artiono Puteri; Yudi Her Oktaviono; Agung Prasmono
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 1 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i1.2022.15-21

Abstract

Abstract: Atrial Septal Defect (ASD) is one of the three most common types of congenital heart disease in the world. Pulmonary arterial hypertension (PAH) is a complication that can be found in patients with secundum type of ASD. There is no research that shows the relationship between patient’s age and defect size with increased pulmonary artery pressure in secundum type of ASD patients in Indonesia, so further research needs to be done. Material and Methods: This study is a retrospective study using an observational analytical research design with cross sectionalapproach. The data from this study were taken from the medical records of ASD patients at the Cardiology and Vascular Department of Dr. Soetomo Public Hospital Surabaya. Results: Sex distribution of patients with secundum ASD was dominated by female patients with a total of 53 people (81.5%), the age distribution of patients was dominated by patients in the age group of 20-24 years as many as 18 people (27.7%). The most common comorbidities in adult secundum ASD patients were hypertension (3.08%) and minor CAD (3.08%). The mean diameter of the secundum ASD defect was 28.03±9.57 mm, and the data for the smallest defect diameter was 4 mm and the largest was 48 mm. Complications of increased PA pressure were dominated by 20 patients with mild PH (30.8%) and the mean mPAP pressure was 39.87±19.03. There were no patients with Eisenmenger syndrome Conclusion: There was no correlation between patient age and inter-atrial septal diameter with mPAP pressure. Keywords: Adult, mean Pulmonary Arterial Pressure (mPAP), pulmonary hypertension (PH), secundum Atrial Septal Defect (ASD)
A Late Prosthetic Mitral Valve Infective Endocarditis Caused by Micrococcus spp. that Fully Recovered by Antibiotics Treatment : A Rare Case Imam Mahbub Zam Zami; Agus Subagjo
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.112-118

Abstract

Prosthetic valve endocarditis is the most severe form endocarditis with prevalence of 5.7% at 5 years and mortality with medical treatment is 26%-75%. Case Summary: Male, 46 years old, with mechanic mitral prosthetic valve >5 years, hemiparesis sinistra due to embolic stroke >4 weeks prior, was suffering from persistent fever >38,5⁰ for 2 weeks without heart failure. Three separate blood cultures came positive with Micrococcus spp. and Osler’s node was noticed. Echocardiography shown 1.0 cm x 0.9 cm vegetation at mitral prosthetic valve without paravalvular leakage. Patient was assessed as late mitral PVE. Discussion: Gentamycin, Levofloxacin, and Erythromycin were given based on susceptibility test continued by Meropenem as therapy of urinary tract infection based on susceptibility test after second blood culture result was negative. The patient underwent 42 weeks of antibiotics course. The patient was discharged with good condition, no signs and symptoms of infection or heart failure, blood test was within normal limit, no vegetations with prosthetic mitral valve functioned normally. This case shows that late PVE caused by Micrococcus spp. can be treated by 42 weeks course of antibiotics according to microbial susceptibility test.
Coronary Thrombosis Case in Female Patient with COVID-19 Confirmed Case: Coincidence or Complication? Yosua Hendriko Manurung; Yusuf Galenta
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.129-133

Abstract

The worldwide health impact of the COVID-19 epidemic has been felt all across the world, mostly due to respiratory issues, but many additional signs such as cardiac manifestations and different thromboembolisms have also been observed. Case Summary. We provide you with a 48-year-old female patient with COVID-19 pneumonia following a severe infection, who developed Unstable Angina due to coronary thrombosis. She has a history of hypertension and obese posture. No diabetes, hypercholesterolemia, or smoking habit had been recorded. And she still has regular menstrual cycle. Around a month prior to being referred to our hospital, this patient has been admitted to ICU of satellite hospital. She was treated with ventilator and discharged around a week before she was admitted to our Emergency Department. She had typical chest pain with ST-segment depression ECG at antero-septal area. PCI was performed and a large thrombosis was found at LAD artery. Discussion: Many studies have showed that COVID-19, through various ways, has developed thromboembolism both in arteries and venous system. The actual process of thrombus development in the coronary arteries is unknown, however, it is thought that pro-inflammatory cytokinesis released by the body, which stimulates the coagulation cascade and prevent fibrinolysis, are the major cause. This condition that leads to hypercoagulable state which eventually makes an increased risk of thromboembolism.
Successful Typical AVNRT Ablation Angela Bety Ratnasari; Budi Baktijasa Dharmadjati
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.119-128

Abstract

AVNRT is the most common regular arrhythmia in humans, and therefore the most commonly encountered during ablation attempts for regular tachycardias. Case Summary: We present a 41-year-old female patient with chest palpitations in the last 10 years, but prior to hospitalization felt heavy sensation on her chest and hospitalized due to heavy chest palpitations and documented SVT. She had no history of hypertension, diabetes mellitus, coronary heart conditions, or stroke. Physical examination showed fair general condition with GCS E4V5M6, blood pressure 130/80, pulse rate 96x / minute, breath rate 18 x / minute and saturation of 99%. Physical examinations are within normal limits. Discussion: Catheter ablation for AVNRT is the current treatment of choice in symptomatic patients. It reduces arrhythmia-related hospitalizations and costs, and substantially improves quality of life. Catheter ablation approaches aimed at the fast pathway have been abandoned; slow pathway ablation, using a combined anatomical and mapping approach, is now the method of choice. This approach offers a success rate of 95 %, has a recurrence rate of approximately 1.3 – 4.0 %, and has been associated with a low risk of atrioventricular (AV) block.
Ventricular Septal Rupture (VSR) in Post-Acute Anterior Myocardial Infarction Patients : A Case Series Ken Christian Kawilarang; I Kadek Herry Hermawan; Febryanti Hartono
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.100-111

Abstract

Case Summary: We present 2 cases of post-STEMI VSR. They had anterior AMI without reperfusion therapy because of patient delay and limited resources. Thereafter apical VSR occurs on 5th day. VSR was suspected because of sudden hemodynamic deterioration and new holosystolic murmur (Grade III/VI) at left parasternal line of fourth-fifth ICS. Then it was confirmed by echocardiography. Both patients underwent hemodynamic stabilization while waiting for surgical therapy. Unfortunately, they deceased because of cardiogenic shock accompanied by other comorbidities. Discussion: VSR causes shunt from left to the right ventricle, which overloads the RV, leading to cardiogenic shock. The peak incidence of VSR in the first 24 hours or 3-5 days post-AMI. This fits both of our cases. VSR occurs in total coronary occlusion, which then causes coagulation necrosis in the ischemic area, characterized by neutrophils that trigger apoptosis and lytic enzymes, so that septum becomes thin, brittle then ruptures. VSR is most common in anterior AMI and the defect is at apical septum, as in our patients. Definitive therapy for VSR is surgical closure, but the best timing is still under debate. This article is expected to make us more aware of post-AMI VSR, so we can quickly diagnose and promptly treat the patients with multidisciplinary approach. This is very important to optimize patient’s outcomes even in limited resources area.
Correlation of Neutrophyl-Lymphocyte Ratio, Vessel Score based on Sullivan Scoring System, and Troponin in Acute Coronary Syndrome Patients Chelssi Gloria Tessari; Achmad Lefi; Yetti Hernaningsih
Cardiovascular and Cardiometabolic Journal Vol. 3 No. 2 (2022): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v3i2.2022.75-86

Abstract

Acute Coronary Syndrome (ACS) is one of the highest causes of death globally, with the number of deaths reaching more than 9 million people in 2016. Therefore, a fast and accurate ACS diagnosis is needed. This study aimed to determine the relationship between the neutrophil-lymphocyte ratio, the number of coronary artery lesions evaluated by angiography, and troponin I in ACS patients Material and Methods: This research is an analytic observational with a retrospective cross-sectional design. Sampling was carried out using a total sampling technique and obtained 87 samples that met the inclusion and exclusion criteria for the 2019-2020 period at Dr. Soetomo Regional General Hospital Surabaya. The correlation between the number of coronary artery lesions and the neutrophil-lymphocyte ratio to troponin I levels were respectively analyzed using chi-square and spearman-rho with SPSS ver. 25. Results: The results showed a moderately significant correlation between the neutrophil-lymphocyte ratio and troponin I levels (p =0.003, rs = 0.319). While the correlation analysis between the number of coronary artery lesions and the vessel score on troponin I showed insignificant results (p = 0.525), which means that the number of coronary artery lesions was not correlated with troponin I. Conclusion: This study concludes a significant correlation with moderate correlation between the neutrophil-lymphocyte ratio and troponin I. However, there is no significant correlation between the number of coronary artery lesions assessed by the Sullivan and troponin I levels.

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