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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : https://doi.org/10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is published online by the Faculty of Pharmacy, Mulawarman University, Samarinda City, East Kalimantan. Since 2019, the Jurnal Sains dan Kesehatan has been accredited to SINTA. Jurnal Sains dan Kesehatan publishes manuscripts (Original research Article, review articles, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Case Study & Full clinical trials, Clinical Pharmacy, Medicine, and other related fields. The purpose of publishing the Jurnal Sains dan Kesehatan is to provide scientific information about the development of science and technology in the field of Science and Health. Lingkup naskah Jurnal Sains dan Kesehatan mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan Jurnal Sains dan Kesehatan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 21 Documents
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Search results for , issue "Vol. 6 No. 1 (2024): J. Sains Kes." : 21 Documents clear
Pengaruh Pengetahuan terhadap Perilaku Penggunaan Obat Antihipertensi di Kelurahan Sungai Miai Banjarmasin: The Influence of Knowledge on the Behaviour of the Use of Antihipertension Drugs in Sungai Miai Sub District Banjarmasin Nurul Mardiati; Anis Hikmah Syabana; Wahyudi Wahyudi
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1399

Abstract

A circulatory system problem that surpasses 120/80 mmHg is known as hypertension. To ensure patient health, it is crucial to understand how antihypertensive medications should be used and how to behave while taking them. In the Sungai Miai Village of Banjarmasin, this study attempts to ascertain the impact of knowledge on the behaviour of antihypertensive drugs. This study is a non-experimental cross-sectional descriptive analytic study. Accidental sampling was employed to get the data, utilizing instruments in the form of questionnaires, depending on inclusion and exclusion criteria. 48 respondents (48%), the majority of hypertensive patients with good knowledge, and 43 respondents, the majority of hypertensive patients with good behaviour, provided the results (43 percent). In Sungai Miai Village, Banjarmasin, information has an impact on how people take antihypertensive medications. Keywords:  Antihypertention, Knowledge, Behavior   Abstrak Hipertensi merupakan gangguan sistem peredaran darah di atas nilai normal yang melebihi 120/ 80 mmHg. Pengetahuan tentang pemakaian obat antihipertensi dan perilaku pemakaian obat antihipertensi ialah perihal yang penting untuk mencapai kesehatan penderita. Riset ini bertujuan buat mengetahui pengaruh pengetahuan terhadap perilaku obat antihipertensi di Kelurahan Sungai Miai Banjarmasin. Riset ini merupakan riset deskriptif analitik non-eksperimental, desain cross sectional. Pengambilan data yang digunakan merupakan accidental sampling berdasarkan kriteria inklusi serta eksklusi dengan instrumen berbentuk kuesioner. Hasil riset yang didapat kebanyakan penderita hipertensi dengan pengetahuan baik ialah sebanyak 48 responden (48%), serta kebanyakan penderita hipertensi dengan perilaku baik sebanyak 43 responden (43%). Terdapat pengaruh pengetahuan terhadap perilaku pemakaian obat antihipertensi di Kelurahan Sungai Miai Banjarmasin. Kata Kunci: Antihipertensi, Pengetahuan, Perilaku
Optimasi Sintesis Nanopartikel ZnO dengan Metode Hidrotermal: Optimization of ZnO Nanoparticle Synthesis using the Hydrothermal Method Rolan Rusli; Ganjar Firmansyah; Rosniar Rosniar; Restu Harisma Damayanti
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1529

Abstract

ZnO is an inorganic material that has many benefits, one of which is in the pharmaceutical field. So far, the synthesis of inorganic materials has been carried out using high temperatures. Research was carried out to synthesize ZnO using hydrothermal at 180°C for 24 hours then burned at temperatures of 300, 600, and 900°C for 6 hours. The compound resulting from synthesis at 180°C was obtained by the compound [Zn(urea)3](NO3)2 which decomposed into ZnO nanoparticle compounds at 300°C to 900°C. ZnO synthesized at temperatures of 300, 600, and 900°C has a hexagonal structure, space group P63/m with lattice parameters a=b= 3.25 Å and c= 5.21 Å and ? = ? = 90° and ? = 120°. The synthesized ZnO has a nanoparticle size in the range of 172-455 nm. Keywords:          ZnO, hydrothermal, synthesis, nanoparticle, hexagonal structure   Abstrak ZnO merupakan material anorganik yang memiliki banyak manfaat, salah satunya dalam bidang farmasi. Selama ini sintesis material anorganik dilakukan menggunakan suhu yang tinggi. Penelitian dilakukan untuk mensintesis material ZnO pada suhu rendah. Metode sintesis material ZnO dilakukan dengan menggunakan hidrotermal pada suhu 180°C selama 24 jam kemudian dibakar pada suhu 300, 600, dan 900°C selama 6 jam. Senyawa hasil sintesis pada 180°C diperoleh senyawa [Zn(urea)3](NO3)2 yang terurai menjadi senyawa nanopartikel ZnO pada 300°C hingga 900°C. ZnO hasil sintesis pada suhu 300, 600, dan 900°C memiliki struktur heksagonal, grup ruang P63/m dengan parameter kisi a=b= 3,25 Å dan c= 5,21 Å serta memiliki sudut ? = ? = 90° dan ? = 120°. ZnO hasil sintesis memiliki ukuran nanopartikel dengan rentang 172-455 nm. Kata Kunci:         ZnO, hidrotermal, sintesis, nanopartikel, struktur heksagonal
Study of Antioxidant Activity, Total Phenolic Content (TPC), and Total Flavonoid Content (TFC) of Ethanolic Extract Mango Peel (Mangifera indica L.) Dyan Wigati; Dwi Koko Pratoko
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mango is one of the fruits rich in phenols and flavonoids, proven to have the ability to scavenge free radicals. The level of compounds in the sample can influence antioxidant capacity, including the total phenolic and flavonoid content. Peel of mango is a non-edible waste. This study aims to determine the total phenolic and flavonoid content and antioxidant activity of mango peel variety arum Manis, extracted by percolation using 70% ethanol. The total phenolic content was measured using Folin-Ciocalteu method, and flavonoid content was measured using AlCl3. The absorbances were measured using UV-Vis spectrophotometry. The DPPH radical scavenging assay to assess antioxidant activity. The result reveals that the mango peel's ethanol extract had a total phenolic content of 19.31±0.41 mgGAE/g extract, a total flavonoid content of 22.06±1.74 mgQE/g extract, and an IC50 value of 766.444 ppm. This research showed that mango peel's antioxidant activity is weak compared to standard vitamin C (6.414 ppm). This is possibly due to the low level of metabolite content, including complexities of the phenolic and flavonoid types in the extract.
Distribusi Kasus Celah Bibir dan Langit-Langit Berdasarkan Jenis Kelamin dan Lokasi Celah di Provinsi Kalimantan Timur Tahun 2020-2022: Distribution of Cleft Lip and Palate Based on Gender and Cleft Location in East Kalimantan Province in 2020-2022 Nida Midati Shadrina; Syahril Samad; Listiyawati Listiyawati; Cristiani Nadya Pramasari; Danial Danial
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1777

Abstract

Cleft lip and cleft palate are the most common congenital malformations of the head and neck and may be associated with other congenital anomalies. The etiology of cleft lip and/or palate has been studied extensively that this anomaly is multifactorial. Risk factors for clefts include gender, genetic factors, and family history. The clinical presentation of cleft palate varies and can be classified as isolated cleft palate or cleft lip with or without a cleft palate. The disorder may involve the lips, hard palate and/or soft palate, either completely or incompletely, and unilaterally or bilaterally. The purpose of this study is to describe the distribution of cases of cleft lip and/or cleft palate based on gender and cleft location in East Kalimantan Province in 2020-2022. This type of research is a descriptive study with total sampling technique. Data were obtained from patient registration forms based on predetermined inclusion criteria. The results showed that of the 77 samples, cases of clefts were more common in males, namely 52 people (67.53%) and females, namely 25 people (32.47%). The most frequent cleft location on the left unilateral were 36 people (46.75%) compared to the right unilateral of 19 people (24.68%), or bilateral as many as 22 people (28.57%). Based on the results of this study, the distribution of cases of cleft lip and/or cleft palate mostly occurs in males, with the location of the cleft more common in the left unilateral. Keywords:          Cleft Lip and Palate, Gender, Cleft Location   Abstrak Celah bibir serta langit-langit ialah malformasi kongenital kepala dan leher yang paling umum dan mungkin berhubungan dengan anomali kongenital lainnya. Etiologi celah bibir dan/atau langit-langit telah dipelajari secara ekstensif bahwa anomali ini bersifat multifaktorial. Faktor risiko terjadinya celah yaitu seperti, jenis kelamin, faktor genetik, dan riwayat keluarga. Presentasi klinis celah mulut bervariasi dan dapat diklasifikasikan sebagai celah langit-langit terisolasi atau celah bibir dengan ataupun tanpa celah langit-langit. Kelainan tersebut dapat melibatkan bibir, langit-langit keras dan/atau langit-langit lunak, baik secara lengkap atau tidak lengkap, serta unilateral atau bilateral. Tujuan penelitian ini adalah menggambarkan distribusi kasus celah bibir dan/atau celah langit-langit menurut jenis kelamin serta lokasi celah di Provinsi Kalimantan Timur pada tahun 2020-2022. Jenis penelitian ini ialah penelitian deskriptif dengan teknik total sampling. Hasil penelitian memperlihatkan bahwa dari 77 sampel, kasus celah lebih kerap dialami laki-laki yakni 52 orang (67,53%) dan perempuan yakni 25 orang (32,47%). Lokasi celah paling sering terjadi pada unilateral kiri berjumlah 36 orang (46,75%) dibandingkan dengan unilateral kanan sebanyak 19 orang (24,68%), ataupun bilateral sebanyak 22 orang (28,57%). Berdasarkan hasil penelitian ini, distribusi kasus celah bibir dan/atau celah langit-langit sebagian besar terjadi pada laki-laki, dengan lokasi celah lebih sering terjadi pada unilateral kiri. Kata Kunci:         Celah Bibir dan Langit-Langit, Jenis Kelamin, Lokasi Celah
The Role of Cathelicidin in Dermatology Skin Diana Kurnia Apriani; Reiva Farah Dwiyana; Anis Yohana Chaerunisaa
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1883

Abstract

Acne, Atopic Dermatitis, Psoriasis and Rosacea are examples of chronic inflammatory skin conditions. One characteristic of many skin disorders is the dysregulation of innate immunity in the skin. Acne, Atopic Dermatitis, Psoriasis, and Rosacea all have problems with the expression, function, or processing of the key innate immune effector molecule in the skin, cathelicidin LL-37. Cathelicidin induction can be altered to treat Acne and Atopic Dermatitis, which lessens the efficiency of the antimicrobial barrier. However, cathelicidin is overexpressed in Psoriasis and Rosacea. The most recent research on cathelicidin LL-37’s involvement in the etiology of inflammatory skin disorders will be included in this review. Since cathelicidin LL-37 may one day be employed as a therapeutic target, many cutting-edge therapy methods for the disease will be discussed. Keywords:          Antimicrobial Peptide, Cathelicidin, Dermatology Skin
Hubungan Tingkat Pengetahuan dengan Sikap terhadap Penggunaan Antibiotik Amoxicillin di Kampung X, Kabupaten Purwakarta: The Relationship Between Knowledge Level and Attitude to Using Amoxicillin Antibiotics in X Village, Purwakarta Herma Yulika; Marselina Marselina
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.1992

Abstract

Antibiotics are drugs that are used to deal with bacterial infections or are bacteriostatic, which prevents the occurrence of bacteria. Amoxicillin is the most well-known antibiotic used by people without a doctor’s prescription. The aim of this study is to analyze the relationship between the level of knowledge and the attitude towards the use of antibiotics Amoxicillin. This research is a quantitative study with cross-sectional approach carried out on 58 respondents in Kampung X  Purwakarta. Questionnaire that has been tested for validity and reliability, SPSS univariat and bivariat analysis chi-square test square. The result of this study is obtained a value (p = 0,000) which means there is a meaningful relationship between the level of knowledge and attitude towards the use of antibiotics Amoxicillin. Respondents whose level of knowledge is less good and have a less good attitude are at risk of using an antibiotic Amoxicillin that does not comply with the rules of use. A good level of knowledge can reduce the adverse impact on the use of antibiotic Amoxicillin that does not comply with the rules of use. Keywords:          Education, Age,  Pharmacy   Abstrak Antibiotik merupakan obat yang digunakan untuk mengatasi infeksi bakteri atau bersifat bakteriostatik yaitu menghambat terjadinya perkembangbiakan bakteri. Antibiotik Amoxicillin merupakan antibiotik yang paling banyak dikenal sekaligus dipergunakan oleh masyarakat tanpa resep dokter. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Menggunakan penelitian kuantitatif yang dilakukan pada 58 responden di Kampung X Kabupaten Purwakarta. Menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya, Diuji  menggunakan SPSS analisis univariat dan bivariat serta uji chi-square kuadrat. Dari penelitian ini didapatkan hasil  dengan nilai (p = 0,000) yang artinya terdapat hubungan bermakna antara tingkat pengetahuan dengan sikap terhadap penggunaan antibiotik Amoxicillin. Responden yang tingkat pengetahuannya kurang baik dan memiliki sikap yang kurang baik berisiko menggunakan antibiotik Amoxicillin yang tidak sesuai dengan aturan pakai. Tingkat pengetahuan yang baik dapat mengurangi dampak negatif penggunaan antibiotik Amoxicillin yang tidak sesuai aturan pakai. Kata Kunci:         Pendidikan, Usia, Apotek
Inhibitor Enzim Papain-Like Protease (Plpro) SARS CoV-2 dan Mediator Inflamasi TNF-? dan IFN-? pada Bawang Putih (Allium Sativum L): Inhibitors of Papain-Like Protease (Plpro) Enzyme SARS CoV-2 and Inflammatory Mediators TNF-? and IFN-? in Garlic (Allium Sativum L) Pipit Romadhona; La Ode Muhammad Anwar; Salma Hilmy Rusydi Hashim
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2010

Abstract

COVID-19 is an infectious disease caused by the SARS CoV-2 virus. Garlic (Allium sativum L) contains compounds that are responsible for immunomodulatory effects and have antiviral activity. This study aims to find out more about the compounds contained in garlic that have the potential for COVID-19 treatment. The research method is in silico. Macromolecules targeting papain-like protease enzyme tethering with code 6B18 and TNF-? mediators with code 1TNF and IFN-? with code 4Z5R. The results of research on 34 compounds in garlic obtained compounds that can inhibit the enzyme PLpro, namely the hyperin compound at -8.7 kcal/mol, compounds that can inhibit TNF-? mediators, namely phytol compounds at -8.0 kcal/mol, and compounds that can inhibit INF-a mediators, namely ergosterol compounds at -8.2 kcal/mol. Keywords:          COVID-19, PLpro, garlic, inflammation, TNF-a, IFN-a, in silico   Abstrak COVID-19 adalah penyakit menular yang disebabkan oleh virus SARS CoV-2. Bawang putih (Allium sativum L) mengandung senyawa yang bertanggung jawab atas efek imunomodulator dan memiliki aktivitas antivirus. Penelitian ini bertujuan untuk mengetahui lebih lanjut senyawa yang terkandung didalam bawang putih yang berpotensi sebagai pengobatan COVID-19. Metode penelitian secara in silico. Makromolekul target penambatan enzim papain-like protease dengan kode 6B18, dan untuk mediator TNF-? dengan kode 1TNF dan IFN-? dengan kode 4Z5R. Hasil penelitian dari 34 senyawa pada bawang putih diperoleh senyawa yang dapat menghambat enzim PLpro yaitu senyawa hyperin sebesar -8.7 kcal/mol, senyawa yang dapat menghambat mediator TNF-? yaitu senyawa phytol sebesar -8.0 kcal/mol dan yang dapat menghambat mediator INF-a yaitu senyawa ergosterol sebesar -8.2 kcal/mol. Kata Kunci:         COVID-19, PLpro, bawang putih, inflamasi, TNF-?, IFN-?, in silico
Formulasi Masker Gel Peel-Off Ekstrak Etanol Daun Petai Cina (Leucaena leucocephala (Lam.) De Wit.) sebagai Antijerawat terhadap Pertumbuhan Bakteri Propionibacterium acnes: Formulation of Peel-Off Mask Gel with Ethanol Extract of Chinese Petai Leaves (Leucaena leucocephala (Lam.) De Wit.) as an Anti-acne Against the Growth of Propionibacterium acnes Bacteria Arfiani Arifin; Natsir Djide; Nurhidayah Nurhidayah
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2075

Abstract

Propionibacterium acnes is one of the gram-positive bacteria that can lead to the development of acne. One of the plants with the potential to be an anti-acne agent is the Petai Cina leaf (Leucaena leucocephala (Lam.) De Wit.). This study aims to formulate a peel-off gel mask preparation of the ethanol extract of Petai Cina leaf (Leucaena leucocephala (Lam.) De Wit.) that meets the physical quality test requirements and to determine the antiacne activity of the formulation. The extraction method used was maceration with 96% ethanol solvent. From the obtained extract, peel-off gel mask preparations were made and tested for their minimum inhibitory concentration (MIC): FI (2.5%), FII (5%), and FIII (10%), Medi-klin® (positive control), and gel base (negative control). The antibacterial activity was tested using the well diffusion method. The results of this study showed that the peel-off gel mask preparations FI (2.5%), FII (5%), FIII (10%), and the gel base (negative control) met the physical quality test requirements. The results of the anti-acne activity testing against the growth of Propionibacterium acnes bacteria obtained concentrations of extract FI (2.5%) 18.53 mm, FII (5%) 18.85 mm, FIII (10%) 22.27 mm, Medi-klin® 26.43 mm, and the negative control of Petai Cina leaf 6 mm. This indicates that the ethanol extract of Petai Cinaleaf has inhibitory effects on the growth of Propionibacterium acnes bacteria as an anti-acne agent. Keywords:          Chinese petai leaves (Leucaena leucocephala (Lam.) De Wit.), Peel-off gel mask, Propionibacterium acnes, Anti-acne   Abstrak Propionibacterium acnes merupakan salah satu bakteri gram positif yang dapat mengakibatkan timbulnya jerawat. Salah satu tanaman yang berpotensi sebagai antijerawat adalah daun petai cina (Leucaena leucocephala (Lam.) De Wit.). Penelitian ini bertujuan untuk memformulasi sediaan masker gel peel-off ekstrak etanol daun petai cina (Leucaena leucocephala (Lam.) De Wit.) yang memenuhi syarat uji mutu fisik dan untuk mengetahui aktivitas antijerawat formulasi sediaan masker gel peel-off ekstrak etanol daun petai cina (Leucaena leucocephala (Lam.) De Wit.). Metode ekstraksi digunakan yaitu metode maserasi dengan pelarut etanol 96%. Ekstrak yang diperoleh dibuat sediaan masker gel peel-off yang telah di uji konsentrasi hambat minimumnya (KHM) dengan konsentrasi ekstrak FI (2,5%), FII (5%) dan FIII (10%), Medi-klin® (kontrol positif) dan basis gel (kontrol negatif). Pengujian aktivitas antibakteri menggunakan metode sumuran. Hasil penelitian sediaan masker gel peel-off FI (2,5%), FII (5%), FIII (10%) dan basis gel (kontrol negatif) memenuhi syarat uji mutu fisik. Hasil pengujian aktivitas antijerawat terhadap pertumbuhan bakteri Propionibacterium acnes diperoleh konsentrasi ekstrak FI (2,5%) 18,53 mm, FII (5%) 18,85 mm, FIII (10%) 22,27 mm, Medi-klin® 26,43 mm dan kontrol negatif daun petai cina 6 mm. Hal ini menunjukkan bahwa ekstrak etanol daun petai cina memiliki daya hambat terhadap pertumbuhan bakteri Propionibacterium acnes sebagai antijerawat. Kata Kunci:         Daun petai cina (Leucaena leucocephala (Lam.) De Wit.), Masker gel peel-off, Propionibacterium acnes, Antijerawat
Aktivitas Antibakteri Nanoemulsi Kombinasi Minyak Sereh (Cymbopogon citratus (DC.) Stapf) dan Minyak Kemangi (Ocimum basilicum L.) terhadap Staphylococcus aureus: Antibacterial Activity of Nanoemulsion of Lemongrass Oil (Cymbopogon citratus (DC.) Stapf) and Basil Oil (Ocimum basilicum L.) Combination against Staphylococcus aureus Nuradnin Hasan; Sri Mulyaningsih; Arif Budi Setianto
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2082

Abstract

Lemongrass oil (Cymbopogon citratus (DC.) Stapf) and basil oil (Ocimum basilicum L.) are secondary metabolites that can be utilized as antibacterials. This study aims to determine the antibacterial activity of nanoemulsion preparation formulations of a combination of lemongrass oil and basil oil against S. aureus bacteria and determine the effective concentration of the mixture of the two. Both oils used were verified including GC-MS analysis, specific gravity, refractive index, solubility in alcohol and acid number. The nanoemulsion preparation formulation contained 4% (v/v) combination of lemongrass oil and basil oil, each fraction consisting of F1 (1:3), F2 (2:2) and F3 (3:1). The resulting preparation was tested for physical properties including organoleptic, homogeneity, viscosity, particle size, pH, irritation test, hedonic test and antibacterial activity test using the pitting diffusion method. The results of GC-MS analysis, lemongrass oil has the main compound components, namely E-citral (38.49%) and Z-citral (25.26%) while basil oil has the main compounds, namely Methyl chavicol (58.14%) and linalool (31.72%). Evaluation of the physical properties of lemongrass oil and basil oil roll-on deodorant preparations met the parameters in accordance with the standard. From the results of the antibacterial activity test for S. aureus, F1 had an inhibition zone of 11.44 ± 2.51 mm, F2 18.89 ± 1.05 mm both included in the strong category and F3 23.78 ± 1.72 mm included in the very strong category. The positive control had a zone of inhibition of 10.56 ± 0.53 mm and the negative control had a zone of inhibition of 0 mm. In conclusion, F3 formulation of roll on deodorant preparation with a combination of lemongrass oil and basil oil (3:1) at 4% has effective antibacterial activity against S. aureus bacteria. Keywords:          Lemongrass oil and basil oil, nanoemulsion preparation, S. aureus   Abstrak Minyak sereh (Cymbopogon citratus (DC.) Stapf) dan minyak kemangi (Ocimum basilicum L.) adalah minyak esensial yang dapat dimanfaatkan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri formulasi sediaan nanoemulsi kombinasi minyak sereh dan minyak kemangi terhadap bakteri S. aureus dan mengetahui konsentrasi yang efektif dari campuran keduanya. Kedua minyak yang digunakan diverivikasi meliputi analisis GC-MS, bobot jenis, indeks bias, kelarutan dalam alkohol serta bilangan asam. Formulasi sediaan nanoemulsi mengandung 4% (v/v) kombinasi minyak sereh dan minyak kemangi yang masing-masing fraksinya terdiri dari F1 (1:3), F2 (2:2) dan F3 (3:1). Sediaan yang dihasilkan diuji sifat fisik antara lain organoleptik, homogenitas, pH dan aktivitas antibakteri dengan menggunakan metode difusi sumuran. Hasil analisis GC-MS, minyak sereh memiliki komponen senyawa utama yaitu E-sitral (38,49%) dan Z-sitral (26,25%) sedangkan minyak kemangi senyawa utamanya yaitu Methyl chavicol (58,14%) dan linalool (31,72%). Evaluasi uji sifat fisik sediaan nanoemulsi minyak sereh dan minyak kemangi memenuhi parameter yang sesuai dengan standar. Dari hasil uji aktivitas antibakteri S. aureus F1 memiliki zona hambat sebesar 11,44 ± 2,51 mm, F2 18,89 ± 1,05 mm keduanya termasuk kategori kuat dan F3 23,78 ± 1,72 mm termasuk kategori sangat kuat. Kontrol positif mempunyai zona hambat 10,56 ± 0,53 mm dan kontrol negatif memiliki zona hambat 0 mm. Kesimpulannya, formulasi F3 sediaan deodoran roll on kombinasi minyak sereh dan minyak kemangi (3:1) sebanyak 4% memiliki aktivitas antibakteri terhadap bakteri S. aureus yang efektif. Kata Kunci:         Minyak sereh dan minyak kemangi, sediaan nanoemulsi, S. aureus
An in Vitro Approach: Antibacterial Activity of Sansevieria trifasciata Prain. Leaves with Chemometric Analysis Henny Kasmawati; Nurramadhani A. Sida; Arfan Arfan; Wa Ode Dian Indrayanti; Arman Rusman
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2087

Abstract

Exploration the antibacterial activity of S.trifasciata Prain. is still limited, therefore this study aims to assess the antibacterial activity of extracts and ethyl acetate fractions of Sansevieria trifasciata Prain. The S.trifasciata leaves was macerated with ethanol 96%, then fractionated using the trituration method with ethyl acetate. The treatment group was divided into positive control group (PC) using ciprofloxacin, negative control (NC) using DMSO, extract, ethyl acetate fraction 5% (ET5%), 10% (ET10%), 20% (ET20%), 40% (ET40 %). Data were analyzed statistically by ANOVA and chemometrically with PCA. The inhibition zone for S.aureus bacteria in each sample is 26.69; 1.40; 23.32;2.82; 6.23; 11.11; 20.15 mm, respectively, E.coli is 26.65;0.63;22.65;3.61;7.11;11.44;21.15 mm respectively, P. aeruginosa is 27.40; 0.00; 23.23; 2.74;7.03;11.69;21.36 mm respectively. Percent inhibition of extract, ET5%, ET10%, ET20%, ET40% on S. aureus bacteria is 82.16; 5.31; 18.12; 36.39; 70.38% respectively, E.coli is 82.67; 11.13; 24.31; 40.56; 76.99% respectively, P. aeruginosa 84.85; 10.01; 25.65; 42.68; 77.98% respectively. Extract and ethyl acetate fraction have significant potential as antibacterial (p<0.05). The results of PCA chemometric analysis showed that the extract and ET40% had similar inhibition zone area to the positive control ciprofloxacin. The extract and the ethyl acetate fraction 40% are promising for development as antibacterials. Keywords:          Sansevieria trifasciata Prain., chemometric, bacterial

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