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Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Published by Universitas Peradaban
ISSN : -     EISSN : 27766241     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Pharmacy Peradaban Journal (Pharm. PJ) merupakan jurnal ilmiah yang diterbitkan oleh Universitas Peradaban, dan dikelola oleh Departemen Farmasi, Fakultas Sains dan Teknologi. Ini adalah majalah profesional yang menawarkan akses terbuka untuk mempublikasikan penelitian yang relevan di semua bidang farmasi. Jurnal ini menyediakan wadah untuk artikel penelitian asli dan review dari berbagai topik kefarmasian. Jurnal ini menerbitkan manuskrip teoritis atau empiris dua kali dalam setahun yaitu pada bulan Januari dan bulan Juli. Jurnal menerapkan peer review untuk memastikan keaslian dan kualitas publikasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 16 Documents
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HUBUNGAN KETEPATAN TERAPI OBAT ANTIDIABETIK ORAL DENGAN NILAI HBA1C PADA PASIEN DIABETES MELITUS TIPE 2 PROLANIS DI PUSKESMAS JATILAWANG Ika Yuliani; Luthfi Hidayat Maulana; Teguh Hary Kartono
Jurnal Farmasi Universitas Peradaban Vol 1 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Diabetes mellitus (DM) is a metabolic disease that has hyperglycemia characteristics caused by abnormalities in insulin secretion, insulin action or both. This research aims to find out the relationship between the accuracy of therapy in patients with type 2 diabetes mellitus in Prolanis in Jatilawang Public Health Center, Banyumas Regency. medical records of patients with type 2 diabetes mellitus The results show that of 41 patients with type 2 diabetes mellitus in the jatilawang puskesmas banyumas district are aged 40-60 years as many as 23 or 56.1%, and aged 61-80 years as many as 18 or (43,996) . Type 2 Diabetes Mellitus patients consisted of 3 male patients (7.3%) and 38 female patients (92.7%), with 18 (46,316) cases of patients with housewives as many as 25 or (61.06) and frequency of work the least is the work of traders and tailors of clothes by 1 patient or 2.4%. Based on the level of education having the most education, namely elementary schools as many as 31 or (75.6%) and the least frequency has D2 education of 1 or 24%. Based on the length of time involved in being a prolanist participant, the highest frequency of prolanis Diabetes Mellitus type 2 patients at the Jatilawang Public Health Center in Banyumas Regency was based on the time of 34 years of 19 patients or (46.3%) and at least 6 patients or (14.6%) with 1-2 years in attendance. Type 2 diabetes mellitus without comorbidities and 22 (53.7%) cases of type 2 diabetes mellitus patients with hypertension. This research uses analytical observational method with sectional crots design. The accuracy of patient therapy results is that the patient who has the right indication is 41 patients (100.0%), the right drug selection is 41 patients (100%), the right dose is 41 patients (100.0%). right patient as many as 40 patients (100%), while for the right way to use as many as 24 patients or 58.5% Hbale value was reached as many as 28 patients or 68.33% and the target patient was not achieved as many as 13 patients or (31.7%). The results were analyzed using spas using Chi-square test The P value of 0.014 indicates that there is a relationship between the accuracy of therapy with the HbAle value in prolanis patients at the Jatilawang Public Health Center in Banyumas district
ANALISIS EFEKTIVITAS BIAYA METODE KONTRASEPSI PIL DAN SUNTIK UNTUK AKSEPTOR KB MANDIRI DI PUSKESMAS TONJONG Ratu Fiqi Hanun; Aziez Ismunandar; Luthfi Hidayat Maulana
Jurnal Farmasi Universitas Peradaban Vol 1 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Based on data from BKKBN in 2015 it is known that the results of contraceptive services in Indonesia in 2012 using injection method contraception 30,649 participants (49.70%), pills 12,068 participants (19.57%), IUD 8,200 participants (13.30%), implants 6,408 participants (10.39%), MOW 2,009 (3.26%), condoms 2,264 participants (3,67%) and MOP 75 participants (0.12%). This will certainly affect the budget of the funds used. The cost-effectiveness analysis of the use of contraceptive methods is carried out to find out which method of contraception is the most cost-effective for society. The purpose of this study is to find out the most cost-effective contraceptive method between pills and injection for independent birth control acceptance at Tonjong Public Health Center. Data retrieval using the patient's medical records and prices on the Pharmaceutical Installation. The population in this study was all birth control patients in Pukesmas Tonjong during July-December 2019. Sampling method with total sampling so that it is obtained by 31 people. This research is a quantitative descriptive study with a cross-sectional research design. The data analysis used in univariate analysis and Cost-Effectiveness Analysis. Based on the results of the study can be concluded that the most cost-effectiveness analysis method based on the value of ACER and ICER, which has the most effective cost that is pills, the smaller the value of ACER a drug then the more cost-effective the drug. The contraceptive pill is in quadrant II which offers high effectiveness and low cost.
ANALISIS KADAR HIDROKUINON PADA KRIM MALAM DI KLINIK KECANTIKAN KABUPATEN BREBESDENGAN SPEKRTOFOTOMETRI UV-VIS Prihastini Setyo Wulandari; Aulia Rahman; Pudjono Pudjono
Jurnal Farmasi Universitas Peradaban Vol 1 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Phenol derivatives that are often misused as active ingredients in making beauty creams that function to whiten facial skin areas, one of which is hydroquinone. This compound is often applied as an active ingredient in the manufacture of night creams. These effects can begin to appear after using A period of 6 months and possibly irreversible. Aims to determine the content, levels, and safety level of facial whitening nights provided by doctors in beauty clinics. Six samples of night cream given by doctors from several regions will go through color, pH, and TLC tests. After that, it will be analyzed quantitatively using the visible spectrophotometry method. The analysis showed that all the cream samples analyzed were proven to contain hydroquinone, with each sample content of less than 1%. All samples of these creams should not be used as cosmetics but must be converted into the category of therapeutic products (drugs) or in other ways remove Hydroquinone ingredients from the formula if they are still produced in the cosmetic category.
PERBANDINGAN MONOTERAPI DAN POLITERAPI EPILEPSI TERHDAP KUALITAS HIDUP PASIEN EPILEPSI DI RSU MUHAMMADIYAH SITI AMINAH BUMIAYU TAHUN 2020 Aina Ainun Nahdhiyah; Ismiyati Ismiyati; Baedi Mulyanto
Jurnal Farmasi Universitas Peradaban Vol 1 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Epilepsi is a common disease, untreated seizures will increase the risk of death injury, cognitive and behavioral disorders and social loss. The purpose of this study was to determine the effect of epilepsy monotherapy and polytherapy on patients at RSUM Siti Aminah Bumiayu. Data collection using observasional analytic methods with cross-sectional design. The subject of the study condisted of 72 epilepsy patients at the neurological clinic of Siti Aminah Bumiayu Hospital obtained by accidental sampling technique starting from April to September 2020. Comparing monotherapy and polytherapy on the quality of life of epilepsy patients as measured by medication adherence using the Morisky Modication Adhrence Scales (MMAS) questionnaire. The result showed that the proportion of patients who received monotherapy was 72,2% and polytherapy was 27,8% while those who received epilepsy drugs phenytoin 56,9% and phenobarbital 15,3% as monotherapy and combination phenytoin+phenobarbital+caffein 27,8% as polytherapy. That there is no comparison of epilepsy monotherapy and polytherapy on the quality of life of patients with epilepsy, namely the p value is 0,998 and 0,999 (monotherapy) and 0,998 (polytherpy) where that p value is > 0,05
PERBANDINGAN TERAPI HIPERTENSI TERHADAP PENURUNAN TEKANAN DARAH PADA PASIEN PROLANIS DI PUSKESMAS KABUPATEN BANYUMAS WILAYAH TIMUR Novi Istianah Azizah; Aziez Ismunandar; Tunjung Winarno
Jurnal Farmasi Universitas Peradaban Vol 1 No 1 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Hypertension is one of the most common cardiovascular diseases and the most common in the community. Hypertension or known as high blood disease is a condition in which systolic blood pressure is more than 140 mmHg and diastolic blood pressure is more than 90 mmHg. The purpose of this study was to determine the comparison of hypertension therapy to lowering blood pressure in prolanis patients. This study used an analytic observational design with a cohort method. The data was collected retrospectively by looking at the patient's drug monitoring book and prescriptions. The population in this study was all hypertension prolanis participants at the Banyumas District Health Center in the East Region including the Sokaraja 1 Puskesmas, Kalibagor Puskesmas, Kemranjen 1 Puskesmas, Tambak 1 Puskesmas, Kebasen Puskesmas and Sumpuih Puskesmas 1. Sampling was carried out using total sampling. The sample in this study were 166 patients. The data analysis in this study used the Kruskal Wallis test. In the Kruskal Wallis the Asymp value was obtained. Sig. 0.060> 0.05, which indicates that there is no meaningful difference between hypertension therapy to lower or stabilize blood pressure. The single antihypertensive that is best in lowering or stabilizing systolic blood pressure is amlodipine. Meanwhile, the best combination antihypertensive in lowering or stabilizing systolic and diastolic blood pressure is the drug Amlodipine + Bisoprolol.
ANALISIS RASIONALITAS PENGGUNAAN OBAT PADA PASIEN HIPERTENSI DI PUSKESMAS BUMIAYU TAHUN 2021 Umatus Sodiqoh; Aziez Ismunandar; Luthfi Hidayat Maulana
Jurnal Farmasi Universitas Peradaban Vol 1 No 2 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Hypertension is an unrelated inherent disease that became one of the main causes of premature death in the world (Hariawan & Tatisina, 2020). Hypertension in Bumiayu Health Center is the most suspected disease in order of number one so that it is necessary to be analyzed the rationality of hypertensi medicine for the achievement of the right and precise hypertension medicine. This research aims to Knowing the pattern of use of antihypertension medicine in Bumiayu Healt Center, knowing the level of rationality of antihypertension medicine use in Bumiayu Health Center, and knowing the outcome of the use of antihypertension medicine in Bumiayu Health Center. Method for this study uses non-experimental observation methods of descriptive analysis with cohort study design through interviewed hypertension patients in Bumiayu Health Center with ethical clearance number B.1524/800.2/iii/2021. The population in this study of 6,514 patients, collect sample is 98 using the Slovin formula and meets the inclusion criteria. The inclusion criteria in this study are hypertension patients recorded in the outpatient register book and get prescription of hypertension drugs, age-based hypertension patients > 45 years, suffering from hypertension with or without complications, and patients are willing to be respondents. The exclusion criteria in this study were respondents refused to participate and responds died. The results of the rationality of medicine use in this study amounted to 53.1% with the patient outcome of 52% of its blood pressure is stable and the result of linear regression shows that there is an effect of rationality of medicine use providing hypertension in patients in Bumiayu Health Center with P value of 0.000 > 0.05.
PENGARUH REAKSI OBAT YANG TIDAK DIKEHENDAKI (ROTD) TERHADAP KEPATUHAN PASIEN TUBERCULOSIS PARU DI PUSKESMAS BUMIAYU 2021 Sabila Zela Safitri; Luthfi Hidayat Maulana; Aziez Ismunandar
Jurnal Farmasi Universitas Peradaban Vol 1 No 2 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

ABSTRAK PENGARUH REAKSI OBAT YANG TIDAK DIKEHENDAKI (ROTD) TERHADAP KEPATUHAN PASIEN TUBERCULOSIS PARU DI PUSKESMAS BUMIAYU 2021Sabila Zela Safitri , apt. Aziez Ismunandar, Luthfi Hidayat MaulanaEmail:Zelasabila@gmail.com Latar belakang : Tuberculosis paru merupakan salah satu penyakit yang menjadi perhatian global dan menjadi salah satu penyakit penyebab kematian di dunia. (Dinkes Jateng, 2019). Pasien yang menderita tuberculosis paru akan mendapatkan obat antituberculosis (OAT) yang dikonsumsi dalam jangka panjang. Beberapa kejadian reaksi obat yang tidak dikehendaki yang ditimbulkan oleh OAT. Kejadian ini diduga dapat mempengaruhi tingkat kepatuhan pasien terhadap pengobatan. Tuberculosis paru di Puskesmas Bumiayu masuk ke dalam 10 penyakit terbayak pada tahun 2020 sehingga perlu dilakukan monitoring reaksi obat yang tidak dikehendaki agar pasien patuh dalam menjalani pengobatan.Tujuan : Mengetahui jenis ROTD yang terjadi kepada pasien penderita Tuberculosis paru di Puskesmas Bumiayu, mengetahui tingkat kepatuhan kepada pasien penderita Tuberculosis paru di Puskesmas Bumiayu dan untuk mengetahui pengaruh ROTD terhadap kepatuhan pasien penderita Tuberculosis paru di Puskesmas BumiayuMetode : Penelitian ini menggunakan studi cohort–prospective dengan melakukan wawancara dan pengisian lembar isian yang terdiri dari 13 macam pilihan ROTD, data kepatuhan didapat dari pengisian kuesioner MMAS-8 kepada pasien penderita Tuberculosis paru di Puskesmas Bumiayu Tahun 2021 dengan nomor ethical clearance B. 1525/800.2/III/2021. Populasi pada penelitian ini adalah sebanyak 47 pasien, dan diperoleh sampel sebanyak 47 pasien yang memeuhi kriteria inklusi yang meliputi Pasien Tuberculosis paru kategori 1 yang telah melakukan pengobatan selama 1 tahun, Pasien Tuberculosis paru yang terdaftar di puskesmas tempat penelitian dan Pasien Tuberculosis yang bersedia menjadi responden dalam penelitianHasil : Hasil analisis SPSS antara reaksi obat yang tidak dikehendaki terhadap kepatuhan minum obat pada pasien tuberculosis paru didapatkan nilai hasil uji persamaan regresi lnier menunjukan hasil signifikasi 0.053 > 0,05 maka Ho diterima yang artinya Reaksi obat yang tidak dikehendaki tidak berpengaruh terhadap kepatuhan pasien penderita Tuberculosis paru di puskesmas bumiayu.Kesimpulan : Jenis ROTD yang banyak dirasakan oleh pasien penderita Tuberculosis Paru pada penelitian ini adalah gangguan gastrointestinal (29.1%), nyeri kepala (26.5%), badan terasa lemah 12.6%, Tidak nafsu makan (11.3%), Kemerahan pada air seni (10.6%). Ttingkat kepatuhan pasien Tuberculosis paru terdapat 2 orang (4,3%) yang termasuk kategori tidak patuh dan terdapat 45 orang (95,7%) yang termasuk kategori patuh. Tidak terdapat Reaksi obat yang tidak dikehendaki terhadap kepatuhan pasien penderita Tuberculosis paru di puskesmas bumiayu dengan nilai value 0,053 Kata kunci: Tuberculosis Paru, ROTD, Kepatuhan
PENGETAHUAN SWAMEDIKASI DISMENOREA SISWI SMK SEMESTA BUMIAYU TAHUN 2020 Dian Trimajaya; Luthfi Hidayat Maulana; Tunjung Winarno
Jurnal Farmasi Universitas Peradaban Vol 1 No 2 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

This research is entitled "Knowledge of Dysmenorrhea Self-Medication for Female Students of “SMK Semesta Bumiayu” Academic Year 2020. Dysmenorrhea is a problem that often occurs to the women during menstruation period. This study aims to determine the knowledge of dysmenorrhea and dysmenorrhoea self-medication to the Female students of “SMK Semesta Bumiayu”. This research is a descriptive quantitative study using a total sampling technique of 252 female students as the respondents. The collected data were analyzed using descriptive analysis technique with the help of the SPSS for windows version 16 application. The results of data analysis showed that most respondents had a good knowledge level of dysmenorrhea (54.8%), and knowledge of dysmenorrhea self-medication with a moderate category (57.1%.).
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN ANTIDIABETIK ORAL PADA PASIEN DIABETES MELLITUS TIPE 2 RAWAT JALAN PESERTA BPJS DI RSUD BUMIAYU 2020 Esa Nurul Jannah; Azies Ismunandar; Luthfi Hidayat Maulana
Jurnal Farmasi Universitas Peradaban Vol 1 No 2 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Diabetes mellitus merupakan salah satu gangguan metabolik yang dikarakteristikkan dengan meningkatnya jumlah glukosa dalam darah dan menurunnya produksi insulin. Prevalensi penderita diabetes mellitus semakin meningkat dari tahun ke tahun dan membutuhkan biaya pengobatan yang tidak sedikit. Penelitian ini bertujuan untuk mengetahui efektivitas biaya penggunaan antidiabetik oral pada pasien diabetes mellitus tipe 2 rawat jalan peserta BPJS di RSUD Bumiayu tahun 2020. Jenis penelitian ini adalah observasional (non-eksperimental). Pengambilan data dari rekam medis dilakukan secara potong lintang (cross-sectional) dan diperoleh sampel sebanyak 34 pasien. Teknik analisis data dilakukan dengan cara menganalisis efektivitas biaya dan terapi penggunaan antidiabetik menggunakan rumus persentase efektivitas terapi, rumus Average Cost Effectiveness Ratio (ACER), dan rumus Incremental Cost Effectiveness Ratio (ICER). Hasil dari penelitian menunjukkan bahwa terapi antidiabetik oral tunggal yang paling cost-effective yaitu glimepirid dengan nilai ACER Rp.4.523.- dan nilai ICER Rp.1.755,- dari alternatif penggantian pioglitazon ke metformin, sedangkan pada antidiabetik oral kombinasi diperoleh nilai ACER Rp.2.843,- dari penggunaan kombinasi metformin dan glimepirid serta nilai ICER Rp.2.722,- diperoleh dari penggunaan alternatif terapi kombinasi pioglitazon dan levemir ke terapi kombinasi metformin, levemir, dan novorapid.
Analisis Kadar Hidrokuinon pada Handbody Lotion dengan Metode Spektrofotometri UV-Vis Sindy Febriani Propita Sari; Eka Trisnawati; Pudjono Pudjono
Jurnal Farmasi Universitas Peradaban Vol 1 No 2 (2021): Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban
Publisher : Prodi Farmasi Fakultas Sains dan Teknologi Universitas Peradaban

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Abstract

Tujuan dilakukan penelitian ini untuk mengetahui kandungan dan kadar hidrokuinon pada handbody lotion yang beredar di pasar induk Bumiayu. Penelitian ini merupakan penelitian deskriptif non eksperimental. Tempat dan waktu penelitian dilakukan di Laboratorium Kimia Jurusan Farmasi Fakultas Sains dan Teknologi Universitas Peradaban Bumiayu pada tanggal 31 Mei sampai dengan 10 Juni 2021. Identifikasi hidrokuinon dilakukan secara kualitatif menggunakan uji organoleptis dengan pereaksi FeCl3 dan reagen Benedict kemudian dilanjutkan dengan KLT, plat yang digunakan sebagai fase diam adalah plat silika gel F254 dan fase gerak berupa kloroform:metanol (1:2) yang menghasilkan noda bercak gelap jika dilihat dibawah sinar UV254. Setelah itu dianalisis secara kuantitatif dengan menggunakan metode Spektrofotometri UV-Vis. Dimana sepuluh sampel handbody lotion yang beredar di pasar induk Bumiayu diperoleh dengan menggunakan teknik simple random sampling. Hasil penelitian menunjukkan bahwa enam sampel handbody lotion positif mengandung hidrokuinon dengan kadar masing-masing yaitu sampel A = 0,23 %, sampel C = 0,25 %, sampel D = 0,23 %, sampel E = 0,26 %, sampel G = 0,05 % dan sampel J = 0,24 %. Dengan demikian dapat disimpulkan bahwa adanya hidrokuinon yang terkandung dalam sampel menandakan bahwa handbody lotion yang digunakan sebagai sampel penelitian ini tidak aman untuk digunakan sebagaimana tercantum dalam BPOM Nomor 18 tahun 2015 tentang persyaratan teknis bahan kosmetik.

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