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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 14 Documents
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Search results for , issue "JKKI, Vol 13, No 3, (2022)" : 14 Documents clear
The role of selenium on autophagy Febriana Kurniasari; Hanna Goenawan; Astrid Feinisa Khairani; Sunarjati Sudigdo Adi; Ronny Lesmana; Setiawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art10

Abstract

Selenium (Se) deficiency is associated with certain abnormalities, such as Keshan disease, cancer, cardiovascular disease (CVD), viral infections, infertility, immune system abnormalities, metabolic diseases, neurological disorders, and growth retardation. Its antioxidant properties are integrated into various selenoenzymes, mainly glutathione peroxidase (GPx) and thioredoxin reductase (Trx). These selenoenzymes act as a protective mechanism to prevent oxidative stress-induced cellular injury, regulate DNA transcription, and cell proliferation. Decreased levels of antioxidants induce reactive oxygen species (ROS) accumulation resulting in loss of mitochondrial structure and function. The antioxidant properties of selenium could depress ROS and modulates autophagy by interfering initiation of autophagy and phagophore formation. Inhibition at the initiation stage not only involves mTOR and AMPK, an autophagy-related regulators, but also autophagy markers, including Beclin 1, Atg5, LC3, and p62; thus, phagophore and autophagosome are not formed. This review will discuss the role of selenium in modulating autophagy in various organs.
Practical support for breastfeeding mothers in achieving exclusive breastfeeding: A scoping review Nur Intan Kusuma; Nidatul Khofiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art11

Abstract

Breast milk is the best food for babies aged 0-6 months and can be given until two years old with complementary food after the baby is 6 months old. Exclusive breastfeeding is a condition when a baby only receives breastmilk for six months. Exclusive breastfeeding is still a global problem because of the low coverage of exclusive breastfeeding. It can be optimized through social support, especially practical support. This scoping review aimed to map the literature, identify knowledge gaps, and review scientific evidence on practical support for breastfeeding mothers in achieving exclusive breastfeeding. The method of this review applied the Arksey and O'Malley’s framework. Four databases such as PubMed, Wiley Online Library, EBSCO, ScienceDirect and grey literature from google scholar were used to search relevant articles by using PEOS. The articles obtained were 1384 articles, and five articles matched the inclusion criteria. The critical appraisal for the five articles indicated four Grade A articles and one Grade B article. The research methods found in the articles were qualitative (60%), quantitative (20%) and mixed method (20%). In addition, three themes of the articles were found in this scoping review, namely the diverse forms of practical support, the benefits of practical support and the expected practical support. Practical support from husbands, families, health workers and communities is suggested for the mothers to achieve exclusive breastfeeding.
Characteristics, microorganism, and antibiotic profile of patients with Fournier’s gangrene in a tertiary care centre in Indonesia: A retrospective analysis of 43 cases Jeremy Thompson Ginting; Gampo Alam Irdam
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art2

Abstract

Background: Fournier’s gangrene (FG) is a fatal condition that often leads to death if not treated properly. To this date, there are no data regarding FG in Indonesia. Objective: This study aims to investigate the characteristics of patients with FG.Methods: A cross-sectional study design was used to evaluate the medical records of patients admitted to Cipto Mangunkusumo Hospital between January 2012 and December 2017.Results: The median age of the subjects were 51 (2-81) years. All of the subjects were male and presented with scrotal pain. The scrotal abscess was found in 38 (88.4%) cases. Type II diabetes was found in 10 (23.3%) subjects. E. coli was the most dominant causative agent in 28 (65.1%) cases. Meropenem was administered in 16 (37.2%) subjects, and 16 (37.2%) subjects had antibiotics administered for ≤7 days. Conclusion: Although the mortality rate has decreased, those with FG tend to have a long hospital stay, which implies a high risk of complications. All males presenting with scrotal pain should be suspected of FG. Further studies on long-term hospitalisation complications in those with FG are required.
A rare primary liver tumour case report: 53-year-old man with primary hepatic leiomyosarcoma Triyanta Yuli Pramana; Paulus Kusnanto; Aritantri Darmayani; Didik Prasetyo; Rahmat Nugroho; Brian Wasita; Widiastuti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art12

Abstract

Primary hepatic leiomyosarcoma (PHL) is a very rare primary liver tumour. These tumours usually arise from intrahepatic vascular structures, gallbladder, or ligamentum teres. The pathogenesis of this disease is still unknown. We report a 53-year-old man with complaints of intermittent right upper abdominal pain for one month, decreased appetite, nausea, weight loss, and tea-coloured urination. The patient denied any complaints of defecation pattern. On physical examination, jaundice was present in both eyes and the whole-body skin, tenderness in the right hypochondriacal region, and enlarged liver with a lumpy surface. The laboratory examination demonstrated increased transaminase enzymes and bilirubin, while hepatitis B and C were negative. The patient underwent several tests for tumour markers, such as CA 19-9 50 (<37 U/mL), AFP 1.23 (<5.81 IU/mL), and CEA 0.83 (<3 ng/mL). Ultrasound demonstrated an enlarged liver, multiple liver nodules, and cholelithiasis. Meanwhile, the abdomen’s computerised tomography (CT) scan shows a solid heterogeneity image with an irregular border in segments 1 and 4b and a tumoral thrombus in the inferior vena cava. The diagnosis was confirmed by biopsy and immunohistochemistry (IHC); vimentin and smooth muscle actin (SMA) results were positive, while CD 34, CD 117, and cytokeratin were negative. Our patient was diagnosed with PHL stage IVa (T4N2M0). PHL is a particularly rare tumour with a poor prognosis. The patient died after one month of diagnosis. Diagnosis of PHL is challenging. It was based on clinical features, physical examinations, laboratory examinations, and other supporting investigations.
Neutrophil-Lymphocyte ratio as a predictor of haemorrhagic stroke outcomes Rohmania Setiarini; Subagya; Ismail Setyopranoto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art6

Abstract

Background: Haemorrhagic stroke causes high disability and mortality. Moreover, the prevalence is increasing. There is evidence of the involvement of the inflammatory process in haemorrhagic strokes. The neutrophil-lymphocyte ratio (NLR) is a strong and easily assessed marker of inflammation. Objective: This study aims to determine the NLR during hospital admission as a predictor of neurological deterioration in acute haemorrhagic strokes.Methods: This study was a prospective cohort study. The subjects were acute haemorrhagic stroke patients treated at the Stroke Unit of the RSUP Dr. Sardjito between March and November 2018. The demographic and laboratory test data, including NLR and National Institutes of Health Stroke Scale (NIHSS) measurement upon admission, were investigated. Logistic regression was performed to identify independent risk factors of neurological deterioration.Results: A total of 65 haemorrhagic stroke patients were included in this study. There were 21 subjects experiencing neurological deterioration, and 44 subjects did not. In bivariate analysis, there was a significant association between hyperglycaemia and neurological deterioration (RR=3.073; 95%CI=1.772-5.329; p=0.011). Glasgow Coma Scale (GCS) at admission was significantly associated with neurological deterioration (RR=2.732; 95%CI=1.455-5.131; p=0.006) as well as the NLR (RR=3.750; 95%CI=1.229-9.4441; p=0.005). The logistic regression results demonstrated that the variables that independently influenced neurological deterioration were NLR (RR= 4.424; 95%CI=1.196-16.369; p=0.026) and GCS (RR=7.461; 95%CI=1.711-32.526; p=0.007).Conclusion: High NLR can predict deterioration in acute haemorrhagic stroke.
Differences of alt-ast level and snail gene expression between patients with metastasis and non-metastasis colorectal cancer Chrisna Budi Satriyo; Hendra Susanto; Adeodatus Yuda Handaya; Nurcahya Setiawan; Imam Sofii; Agus Barmawi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art5

Abstract

Background: Colorectal cancer (CRC) is a malignant epithelial tumour in the colon and rectum, and its main cause is distant metastasis. The main process of distant metastasis is the epithelial-mesenchymal transition (EMT) that may cause mesenchymal phenotype and malignant capabilities of tumour cells. Then it is regulated by one of transcription factors, the Snail.Objective: This study aims to determine differences between Snail gene expression in CRC that has not metastasized and Snail gene expression in CRC that has metastasized. Methods: The subjects of this study consisted of two groups of patients. The first group consisted of 20 patients with CRC (tumour), and the second group consisted of 12 patients with CRC with metastasis (metastasis tumour). The Snail gene expression was measured in both groups by using the RT-qPCR method and supported by laboratory examination to measure ALT and AST. Then all obtained data were analysed by using a statistical software analysis.Results: This study indicated that there were differences of the Snail gene expression between both the groups, and the highest expression was in the metastatic tumour group with a significance level of 0.002 (p<0.05). This was also supported by AST and ALT which were significantly correlated between both the groups. The correlation value on the AST was 0.506 with a significance level of 0.003, and the ALT correlation value was 0.532 with a significance level of 0.002. Conclusion: This study suggested that the Snail was a potential marker of metastasis in the CRC. Therefore, further research is needed to determine the role of Snail regulation in the CRC metastasis.
Determinan Akses Layanan Kesehatan bagi Orang dengan HIV/AIDS di Indonesia Afief Mulyawijaya; Afrizal Adi Nugroho; Dinda Alsayla; Hasnadya Fathin; Anindya Nurshifa; Titik Kuntari; Benyamin Tri Dharma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art7

Abstract

Background: HIV/AIDS is a global health problem, including in Indonesia. PLWHA's access to health services has not been evenly distributed. Only about 63% of PLWHA received initial antiretroviral therapy, 18% died, and 25.4% experienced drug withdrawal. Therefore, research is needed to determine the factors influencing the access of PLWHA to health services.Objective: This study aims to determine the factors related to access to health facilities in Indonesia for people living with HIV/AIDS (PLWHA) in Indonesia.Methods: This study uses secondary data from the 2017 IDHS. The case group was PLWHA, who had not visited a healthcare provider in the last six months. The control group was PLWHA patients who visited a healthcare provider during the last six months. The variables were the patient's and their partner's education level, types of residence, occupation, health insurance, type of health facility, and access to health facilities in the last six months. Multivariate analysis was performed by logistic regression.Results:The PLWHA access to health services was not significantly related to education level, spouse's education level, type of residence, occupation, and type of health insurance (p-value >0.05). The access is significantly related to the health facility types (OR= 4.04; 95% CI 1.173-13.955).Conclusion: The factor determining access to health services for PLWHA in Indonesia is the type of health facility. The government must make various efforts to improve the quality of facilities and services in all health facilities types to increase the number of PLWHA who undergo tests and therapy.
HUBUNGAN RIWAYAT KEHAMILAN, STATUS ASI EKSKLUSIF DAN IMUNISASI DENGAN STUNTING Aisyah Lahdji; Hema Dewi Anggraheni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art8

Abstract

Background: Stunting is one of the global problems that can increase morbidity, mortality, poor development, and infections in children. Some risk factors that escalate stunting incidence are pregnant women, insufficient breastmilk, infection, and the environment.Objective: This study aims to determine the association between pregnancy history, exclusive breastfeeding, and immunisation status with stunting incidence.Methods: This observational study employed a case-control design. The independent variables were pregnancy history, exclusive breastfeeding, and immunisation status. Meanwhile, the dependent variable was stunting incidence. The study subjects were 40 respondents, consisting of 20 respondents diagnosed with stunting and 20 respondents of control.Results: This study revealed an association between a history of low birth weight (p=0.028), too early provision of complementary food in addition to breast milk (p=0.011), no antenatal care (ANC) examination (p=0.000), and exclusive breastfeeding (p=0.028). However, these factors are not significantly different from the immunisation status (p=0.548).Conclusion: This study concluded an association between pregnancy history and exclusive breastfeeding with stunting.
Kadar Plasma 25-Hydroxyvitamin-D (25-OHD) pada Pasien Age-related Macular Degeneration (AMD) Stadium Akhir di Yogyakarta: Studi Korelasi Supanji Supanji; Dewi Fathin Romdhoniyyah; Ayudha Bahana Ilham Perdamaian; Anindita Dianratri; Muhammad Bayu Sasongko; Angela Nurini Agni; Tri Wahyu Widayanti; Firman Setya Wardhana; Dian Caturini Sulistyaningrum; Mohammad Eko Prayogo; Masashi Kawaichi; Chio Oka
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art3

Abstract

Background: Age-related Macular Degeneration (AMD) is a degenerative disease caused by multiple factors, including inflammation. This condition may lead to irreversible macular damage. Vitamin D has anti-inflammatory and immune-modulating qualities, therefore, is expected to protect against the development of AMD.Objective: This study aimed to evaluate the correlation between plasma 25-hydroxyvitamin D (plasma 25-OHD) levels and neovascular Age-Related Macular Degeneration (nAMD).Methods: This was a case-control study involving AMD and control subjects. All subjects underwent a standardized eye examination to check for eligibility by a retinal specialist. Blood samples were drawn for analysis using a DRG Elisa Kit to determine the plasma 25-OHD (Total). Plasma 25-OHD levels were categorized into deficiency (<12 ng/mL), insufficiency (12 - <20 ng/mL), adequate (20 – 50 ng/mL), and high (>50 ng/mL).Results: Total subjects were 39, which consisted of 20 AMD subjects and 19 controls. There were 17 male subjects (43.6%) and 22 female subjects (56.4%). The mean age for the case and control group was 69.35±7.04 and 68.26±6.83, respectively (p=0.612). Those in their 70s dominated the age distribution with a percentage of 56.41% of all participants. The mean plasma 25-OHD in the case group was 32.30±17.10 ng/mL, while the control group was 50.63±11.95 ng/mL (p=0.066). There was no significant association between AMD and plasma 25-OHD levels in all groups (p>0.05).Conclusion: Plasma 25-OHD levels did not correlate positively with nAMD in our study population.
Infective endocarditis due to Achromobacter xylosoxidans: A case report and a literature review Oktania Candrawati; Indah Kartika Murni; Osman Sianipar
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art13

Abstract

Congenital heart disease (CHD) and invasive cardiac procedures are risk factors for infective endocarditis (IE) in children. IE with Achromobacter xylosoxidans is a rare case and has a high mortality rate. This case report and literature review aim to understand the risk factors, diagnosis, therapy, and outcome of IE wirh Achromobacter xylosoxidans. We observed a 14-months-old boy with ventricular septal defect (VSD), a history of cardiac catheterization, 9 days fever and febrile convulsion; and tachycardia and pansystolic murmur on the tricuspid valve were found. Transthoracic echocardiography revealed vegetation on the tricuspid valve. Monomicrobial clinical isolates of Achromobacter xylosoxidans were consistently found in three samples of aerobic blood culture bottles. The patient was treated with definitive antibiotic therapy with 200 mg/8 hours of ceftazidime for 21 days. Bacterial growth was not found in the blood culture evaluation which was performed after 48 hours of the therapy. Also, it was found that in the follow up period the patient had no fever on the sixth day, and the vegetation size was reduced. A patient with CHD, especially with VSD as an underlying condition who had a history of cardiac catheterization and accompanied by fever and heart murmur, should be suspected of having IE. Then the definitive antibiotic therapy with ceftazidime contributed to a better clinical outcome.

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