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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 15 Documents
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Search results for , issue "JKKI, Vol 14, No 1, (2023)" : 15 Documents clear
Managing fractures in geriatrics: Current approaches and update Tito Sumarwoto; Dhimas Hartanto; Pamudji Utomo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art11

Abstract

Geriatric fractures refer to fractures that occur in older people, typically resulting from low-energy trauma and accompanied by osteoporosis. The bone remodelling process imbalance significantly contributes to age-related bone loss in geriatric, which reduces bone mass, making them more susceptible to fractures. Managing geriatric fractures poses unique challenges due to the presence of other comorbid conditions that can interfere with the healing process. Thus, restoring stability is prioritised over reversing anatomy and biology. The use of medication is often helpful in treating osteoporosis. Diagnosing and managing geriatric fractures is a complex process that requires careful consideration of various comorbid factors associated with older patients. Both non-operative and operative management requires thorough preparation. The primary goal of fracture management in older people is to achieve patient independence. Factors such as age, gender, comorbid conditions, pre-fracture functional abilities, and fracture type can impact the outcome regarding ambulation, daily activities, and quality of life. Therefore, it is essential to consider all these factors while managing geriatric fractures.
The potential of sweet orange (Citrus sinensis) in cardiovascular health: A literature review Gabriella Stephanie Minami; Ellya Catharine Lumbantoruan; Puteri; Risa Nuraini; Joan Carmen Harianto; Andhi Fahrurroji
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art12

Abstract

Consumption of fast food and sedentary lifestyles has recently developed in society. This activity is one of the causes of various degenerative diseases, including cardiovascular disease. Therefore, efforts are needed to prevent it. Sweet orange (Citrus sinensis) is one of the most common types of citrus fruit, with total production reaching 70% of all types. This type of fruit is the most widely produced and consumed by the world’s population. Sweet orange is known for its bioactive compounds that have many benefits in cardiovascular health, such as alkaloids, flavonoids, tannins, phenols, vitamins C, B1, B2, and B3, glycosides, coumarin glycosides, folic acid, some organic acids, essential oils, and saponins. Flavonoids are components of secondary metabolites that play a role in the cardiovascular system. The main components of these compounds are hesperidin and naringenin. Various studies have shown that these compounds are active in reducing hyperlipidemia, improving endothelial function, acting as an anti-inflammatory and anti-atherosclerotic agent, preventing myocardial infarction, and preventing cardiac hypertrophy through various mechanisms with low toxicity.
Growth hormone administration and exercise combination increase serum IGF-1 levels in perimenopausal wistar rats Ni Luh Kadek Alit Arsani; Luh Putu Ratna Sundari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art9

Abstract

Background: Growth hormone (GH), Insulin-like growth factor 1 (IGF-1), and exercise play a crucial role in female reproductive function. At the perimenopausal age, there is a decrease in GH, estrogen, and testosterone levels. In previous studies, the impact of physical activity on serum IGF-1 levels in geriatric was inconsistent and needed further investigation. Objective: The purpose of this study was to look into the effect of GH and exercise on serum IGF-1 levels in perimenopausal Wistar rats. Methods: It is an experimental study with a randomized posttest-only control group design using 24 perimenopausal Wistar rats aged 14 months as the sample. The control rats (C) were given 0.1 ml of distilled water subcutaneously every day for 30 days. Treatment group 1 (T1) rats swam for 30 minutes at a time five times per week. Meanwhile, rats of T2 were given 0.016 IU/0.1ml GH daily injection subcutaneously only for 30 days and T3 were given combination both of GH injection in same dose and swam for 30 minutes at a time 5 times a week for 30 days Data analysis used One-Way ANOVA.Results: The finding revealed that the mean serum IGF-1 levels in the T3 (588.50 84.04 ng/mL) were significantly higher than the control (242.03 ± 46.08 ng/mL), T1 (334.23 ± 75.90 ng/mL) and T2 (428.69 ± 95.10 ng/mL). Conclusion: Our study shows that GH administration and exercise combination increases levels of IGF-1 serum higher than only administrated GH or exercise.
Relationship between age, education and blood zinc levels, with cognitive function in menopausal women Gea Pandhita; Martiem Mawi; Mieke Nuryani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art6

Abstract

Background: The increase in life expectancy results in an increase in the number of elderly, especially menopausal women. Aging can have an impact on the decline of cognitive function. The decline in cognitive function and being influenced by age can also be affected by education and blood zinc levels. However, various research results still need to be more conclusive regarding how much influence age, education, and blood zinc levels have on cognitive function.Objectives: To determine the relationship between age, education, and blood zinc levels with the cognitive function of elderly menopausal women.Methods: This research is analytical research with a cross-sectional design. The subjects of the study were menopausal women aged 60 years and over who was able to walk without help, as well as being able to read and write. Study subjects who suffered from a stroke, heart, kidney, mental function disorders, and used drugs for mental disorders, were not included in this study. Research subjects who met the eligibility criteria were carried out with physical examinations (age, height, weight, blood pressure) and laboratory examinations (blood sugar ad random and blood zinc levels), as well as undergoing cognitive function tests using MoCA-INA.Results: A total of 65 study subjects met the eligibility criteria. Multivariate statistical analysis showed that there was a correlation between the cognitive function of the attention domain with age (r=0.278, p=0.030), the cognitive function of the visuospatial domain with education (r=0.528, p=<0.001), the cognitive function of the language domain with blood zinc levels (r=-0.279, p=0.019) and the cognitive function of the orientation domain with education (r=0.319, p=0.012).Conclusions: The results of this study show that there is a meaningful relationship between age, education, and blood zinc levels, with cognitive function in elderly menopausal women.
Association between melanin and vitamin D: A systematic review Andre Colin Hartono; Veronika Maria Sidharta; Yunisa Astiarani; Regina Regina
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art13

Abstract

Globally, there is an increasing prevalence of vitamin D deficiency, including in Southeast Asia, which ranges from 6% to 70%. Vitamin D plays an important role in calcium metabolism and bone health. Melanin is one factor that contributes to vitamin D deficiency. It has photoprotective properties that inhibit vitamin D synthesis, but the mechanism has not been fully understood. To determine the mechanism of the association between melanin and vitamin D, this systematic review was conducted on 11 articles, including cross-sectional studies, cohort studies, and randomised controlled trials published from 2010 to 2020. The search included Pubmed, EBSCO, and Proquest databases, and data were synthesised from 11 studies. This critical review found nine of the 11 studies reported a significant association between melanin and vitamin D, while two reported non-significant results. Of the nine significant studies, eight reported that people with higher melanin have lower vitamin D levels, while one study suggested that melanin levels do not necessarily associate with lower vitamin D levels. In conclusion, the review establishes a significant association between melanin and vitamin D.
The effect of murottal Al Qur'an on the dysmenorrhea intensity among senior high school students Fathimah Az Zahra; Tri Wahyuliati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art3

Abstract

Background: Dysmenorrhea or pain during menstruation is due to excessive contractions during the sloughing of the uterine wall with symptoms of cramping pain in the lower abdomen. The incidence of primary dysmenorrhea in Indonesia is 54.89%. However, many teenagers do not know how to manage the pain. The pharmacological therapy of dysmenorrhea includes painkillers and anti-prostaglandin, while the non-pharmacological approach includes distraction therapy. One of the distraction therapy that is easy to do is murottal Al-Qur’an.Objective: This study observed the role of listening to murottal Al-Qur’an on the intensity of dysmenorrhea among senior high school students.Methods: The design of this study is a quasi-experimental pretest-posttest with a control group design. There were 100 subjects aged 15-18 years old. The sampling technique applied purposive sampling. Data analysis of this study applied Wilcoxon, Mann-Whitney, relative risk (RR), and number needed to treat (NNT) test.Results: The mean pain level in the experimental and control group were 5.42 and 5.56 before intervention. After therapy, the pain level decreased to 2.86 and 5.30 in the experimental and control group, respectively. There was a significant difference in the pain level before and after in the experiment group (p <0.001). Relative risk showed that murottal intervention decreases the pain level by 3.267 times. NNT of the study was 1.467.Conclusion: Murottal Al-Qur’an significantly reduced the degree of pain with a p-value <0.001
Successful combination therapy of low-dose aspirin and unfractionated heparin in recurrent pregnancy loss: A case report Adhi Pribadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art14

Abstract

Habitual abortion, defined as more than two consecutive pregnancy losses, affects approximately 1% to 2% of women. This pathological condition undoubtfully frustrates a woman, yet this condition still has a chance to be treated and achieve a favorable pregnancy outcome. This case report aims to describe the success of a pregnancy with a history of recurrent miscarriages (five times of baby loss). The administration of a combination of low-dose aspirin and unfractionated heparin offers a 72-80% chance of having a good pregnancy outcome. We present a P2A5 woman with Thalassemia Minor and thrombocytosis. Preventive treatment, prenatal diagnosis, pregnancy outcomes, and complications were reviewed. Combination therapy of 80 mg aspirin and 2 x 5000 U unfractionated heparin subcutaneously during the last two pregnancies were able to maintain the pregnancy and prevent early pre-eclampsia or Fetal Growth Restriction (FGR) but not late-onset one. In the 6th pregnancy, the patient experienced late-onset FGR with a minor congenital anomaly. In the 7th pregnancy, severe pre-eclampsia appeared. However, administration of combination of heparin and aspirin could maintain pregnancy and fetal viability in Thalassemia Minor patients with recurrent abortus and thrombocytosis.
Bahasa Inggris Caecielia Makaginsar; Meta Maulida Damayanti; Yuniarti; Siska Nia Irasanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art7

Abstract

Background: Good knowledge and behaviours are crucial to prevent coronavirus disease (COVID-19) transmission in boarding school communities during the pandemic.Objective: To evaluate the relationship between sociodemographic characteristics, knowledge, and behaviours to prevent COVID-19 among students in an Islamic boarding school. Methods: A descriptive cross-sectional study was conducted in March 2021 at the Manarul Huda Islamic Boarding School on 39 students who met the inclusion criteria. Sampling was employed using the total sampling technique. Variables analysed were students’ age, education level, knowledge, and behaviour on COVID-19 prevention as measured using a closed questionnaire. Data were then analysed univariately using frequency distribution and bivariate using the Chi-Square (χ2) and Fisher’s Exact test. Results were considered significant if the p-value was < 0.05.Results: No significant relationships were found between age and knowledge of COVID-19 (p = 0.97); education level and knowledge of COVID-19 (p = 0.619); age and behaviours to prevent COVID-19 transmission (p = 0.136); and education level and behaviours to prevent COVID-19 transmission (p = 0.399) among of the Islamic boarding school students. In contrast, knowledge was significantly (p = 0.035) linked with behaviours to prevent COVID-19 transmission among students.Conclusion: There is a relationship between knowledge and behaviours in preventing COVID-19 among students. However, no relationship was found between demographic characteristics of age and educational level and knowledge and behaviours to prevent COVID-19 in our study participants.
HASIL FUNGSIONAL PADA OSTEOARTRITIS LUTUT SETELAH INTERVENSI PROLOTERAPI DEKSTROSA: STUDI PILOT BERBASIS KEPARAHAN Yose Waluyo; Sari Rajwani Artika; Insani Nanda Wahyuni; Endy Adnan; Budu; Agussalim Bukhari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art8

Abstract

Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as a gold standard to determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known to be effective in treating pain in knee osteoarthritis, but none has compared the efficacy between mild and moderate-severe knee osteoarthritis. Objective: This study aims to compare the effectiveness of prolotherapy based on its radiological and symptomatic severity in knee osteoarthritis.Methods: In this pre-post study, the participants who underwent dextrose prolotherapy injection (25% intra-articular and 15% periarticular) for three sessions with four weeks intervals were grouped into mild (grade 1-2) and severe (grade 3-4) groups. Participants’ functional status was measured with Western Ontario and McMaster Universities’ arthritis index scores at baseline and week 12.Results: A total of 21 patients (average age 61.42 ± 8.33, BMI 26.81± 3.72) received three therapy sessions. Both groups had significantly better Western Ontario and McMaster Universities arthritis index scores than baseline (-22.57± 11.9; p = 0.002 and -15.42 ± 15.75; p = 0.003). All parameters were improved significantly (p <0.05) in both groups, except the stiffness score (p = 0.292; p = 0.057). There were no differences in functional outcome improvements in both groups (p > 0.05; CI 95%: -21.3 – 7.05).Conclusion: Prolotherapy effectively improves functional outcomes in all stages of knee osteoarthritis.
Analysis of C-reactive protein/albumin ratio as a predictor of mortality in sepsis patients Uswatun Hasanah; Irda Handayani; Asvin Nurulita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 1, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss1.art4

Abstract

Background: Sepsis is a leading cause of death among critically ill patients with infections. Abnormal levels of C-reactive protein (CRP) and albumin in sepsis patients have been shown to predict mortality. Combining the two markers can increase the predictive value of mortality.Objective: The aim of this retrospective cohort study was to determine the cut-off value for the CRP/albumin ratio that could be used to predict mortality in patients with sepsis. Methods: Secondary data from 63 medical records of sepsis patients treated in the ICU of RSUP dr. Wahidin Sudirohusodo Makassar from January 2018 to December 2020 was used. Statistical analysis was performed using the Kolmogorov-Smirnov and Mann-Whitney tests. The prognostic value of the CRP/albumin ratio was analyzed using the ROC curve to obtain a cut-off value. A p-value < 0.05 was considered significant. Results: The sample included 43 deceased and 20 living patients with sepsis. The CRP/albumin ratio was significantly higher in the deceased patients (15.4) than in the living patients (2.4) (p<0.001). The ROC curve analysis revealed a CRP/albumin cut-off value of 4.3 with a sensitivity of 81.4%, specificity of 75.0%, positive predictive value (PPV) of 87.5%, negative predictive value (NPV) of 65.2%, and an accuracy of 79.4%. Conclusion: The study suggests a significant relationship between the CRP/albumin ratio and mortality in patients with sepsis. A CRP/albumin ratio of 4.3 can be used as a predictor of mortality in sepsis patients.

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