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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 9 Documents
 1 
Search results for , issue "JKKI, Vol 8, No 1, (2017)" : 9 Documents clear
Global challenge of early detection and management of chronic kidney disease Ana Fauziyati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art1

Abstract

No Abstract
The effect of Tumeric Rhizome (Curcuma Longa L) on radial arm maze and passive avoidance test in Trimethyltin-induced rat models Sapto Yuliani; Leni Setiani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art2

Abstract

Backround : Oxidative stress can cause death of hippocampal cells associated to the deficit of learning and memory function. Turmeric rhizome contains curcuminoid which has antioxidant activity that can prevent oxidative stress, thus it was expected to prevent the deficit of learning and memory function on trimethyltin (TMT)-induced rat models. Objectve : This study aimed to determine the effect of turmeric rhizome extract on cognitive learning and memory fuction which was tested using radial arm maze and passive avoidance tests on Wistar rats injected with TMT. Methods : A total of 30 Wistar rats, male, 8-12 weeks of age were divided into 6 groups. The first (normal) group was given CMC-Na, the second (TMT) group was given CMC-Na, the third-the fifth groups were given turmeric rhizome extract (TRE) orally in the dosage of 120mg/kgBW (TRE120), 240 mg/kgBW (TRE240) and 480 mg/kgBW (TRE480), respectivelly. The sixth (P500) group was given piracetam in the dosage of 500 mg/kgBW. Treatments were given for 8 days orally. At day-9th, excluding the first group, all rats were injected with 12 mg/kgBW TMT solution intraperitoneally. One day after TMT injection, the cognitive learning and memory function was measured using radial maze and passive avoidance tests. The datas of cognitve function tests were analyzed statistically by ANOVA test followed by LSD test at significance level 0.05. Results : The results of radial maze and passive avoidance tests showed that the TRE240 group was not statistically significant different with TMT group(p>0.05). However there were significant difference between TRE120 and TMT groups, as well as between TRE480 and TMT groups (p<0.05). The administration of 480 mg/kgBW of TRE showed that its cognitive function was not significantly different with the administration of Piracetam (p>0.05). Conclusion : It can be concluded that the administration of 480 mg/kgBW of TRE can improve cognitive learning and memory function of Wistar rats injected by TMT.
Effects of ethanolic extract of arrowroot tubers (maranta arundinacea l.) on the level of MDA, SGPT and SGOT in ethanol induced rats Muhammad Reza Ramadhani; Mochammad Saiful Bachri; Wahyu Widyaningsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art3

Abstract

Background : The exposure of free radicals can induce oxidative stress. In the liver, this process will cause impaired liver function. Oxidative stress can be inhibited by antioxidants. Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids and saponin compound that are potential as antioxidants. Objective : Determine the effect of ethanolic extract of arrowroot tubers (Maranta arundinacea) against oxidative stress using the parameter of MDA, SGPT and SGOT level in ethanol-induced rats. Methods : Animal models were divided into 5 groups, in which each group contained 6 rats. Group I (normal) and group II (control) was induced with CMC Na 0,5%. Group III, IV and V were given ethanolic extract of arrowroot tubers in the dosage of 125, 250 and 500 mg/Kg/day respectively. The extract was administered orally for 14 days. Induction of ethanol 5 gram/ KgBW was administered orally 1 hour after the last administration on day 14th except for group I. On day 15th, the animal blood was drawn to measure the levels of SGPT and SGOT, then the animals were sacrificed and their organs were analyzed to measure the levels of MDA in the liver. Data obtained in the form of MDA, SGPT and SGOT levels were statistically analyzed using ANOVA. Results : There is statistically significant difference between the utilization of ethanolic extract of arrowroot tubers (Maranta arundinacea) group with the control group in reducing the concentration of MDA (p<0,05), SGPT, and SGOT (p<0,05). Conclusions : The ethanolic extract of arrowroot tubers (Maranta arundinacea) is able to reduce the concentration of MDA, SGPT and SGOT in ethanol-induced rats.
D-galactose-induced animal model of male reproductive aging Evy Sulistyoningrum
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art4

Abstract

Aging is a complex biological process involving molecular, cellular and organic changes. Aging process is not merely caused by chronological age but it can be accelerated by environmental factors contributes to oxidative stress. Aging in male reproductive system is characterized by many conditions such as terticular atrophy, decreases testicular function of spermatogenesis, decreased testicular function of testosteron production which can lead to a serious clinical condition, infertility. Management of male infertility with excellent outcome is still a challenge and therefore new strategies need to be examined. Because of difficulties and ethical issues in human research, animal models of male reproductive aging are useful research tools for this purpose. Rodent models of male reproductive aging are the first choice because similarity of metabolism system and short lifespan. D-galactose animal model for aging seems to be closer to human aging of male reproductive system. It is an advantageous model for testing potencies of pharmacological agent and natural compounds on aging.
Fusion gene bcr-abl: From etiopathogenesis to the management of chronic myeloid leukemia Tri Agusti Sholikah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art5

Abstract

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm. CML is relative frequent disorder. Most of CML patients have Philadelphia chromosome (Ph),which is derived from a reciprocal translocation between chromosome 9 and 22, t(9;22)(q34;ql1), generating the BCRABLfusion gene. In general, there are 3 breakpoint cluster regions in BCR gene : mayor(M-bcr), minor (m-bcr) and micro (μ-bcr). The BCR-ABL gene encodes proteins that vary in size depending on the breakpoint in the BCR gene. However, these proteins share a high tyrosine kinase activity. In the absence of activating stimuli, BCR-ABL tyrosine kinase able to transferphosphate from ATP (autophosphorilation) to tyrosine residues on various substrates in the cell. It actives intracelluler signaling pathways. These pathways cause increase proliferation or decrease apoptosis and differentiation of a hematopoietic stem cell; and defect in adherence of myeloid progenitors to marrow stroma resulting in CML. These discoveries determined that BCR-ABL fusion gene is critical event in etiopathogenesis of CML and a ideal target for therapy. Therapy of CML patients with BCRABL fusion gene-positif is by block autophosphorilation mechanism by Tyrosine Kinase Inhibitor (TKI), example imatinib. Molecular method to detect BCR-ABL transcript is necessary for monitoring response to TKI in CML pateints.
Kerley a line in an 18-year-old female with acute pulmonary edema and chronic kidney disease stage V Agus Nur Salim Winarno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art6

Abstract

The incidence of chronic kidney disease (CKD) continues rising recently. Chronic kidney disease is associated with many multiple complications. One of the complications related to the emergency situation is acute pulmonary edema (APE). Acute pulmonary edema is a condition where there is acute fluid accumulation in the lungs. Acute pulmonary edema can cause respiratory distress and severe hypoxia. Early recognition and initial treatment shall be considered to prevent further morbidity and mortality. This will be presented a case of 18-year-old female who came to the hospital with progressive dyspnea. After further diagnostic procedures, diagnosis of APE and CKD are constructed. Initial treatment in the emergency room did not give a good response. Then, the patient referred to the higher level hospital to receive possible dialysis treatment.
Histopathological diagnostic criteria of barrett esophagus and its association with endoscopy findings Ukhti Jamil Rustiasari; Diah Rini Handjari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art7

Abstract

Background : In the last decades, the incidence of esophageal adenocarcinoma has significantly increased. Barrett Esophagus (BE) is widely known as a precursor lession of esophageal adenocarcinoma, and it could increase the risk of adenocarcinoma to 30-120 times higher than non-BE patient. The controversy about BE definition is still a problem amongst pathologist. BE is defined as the transition of normal esophageal squamous epithellium into metaplastic columnar epithellium that can be seen through endoscopy at the upper region of gastroesophagus transitional area, and confirmed with hystological examination. Objective : To re-evaluate hystopathological presentation of BE and the classification of dysplasia as well as its association with clinical finding in the form of endoscopy results. Methods : Clinical and hystopathological datas of 71 cases of BE was collected and re-evaluated based on British Society of Gastroenterology Guidelines 2005 criteria, as well as re-evaluating the grade of dysplasia based on WHO Classification of tumours of the digestive system 2010. Results : 51 cases of BE were obtained with male:female ratio 33:18 patients. BE cases were predominated by 51-60 years old age group, in which the mean of patients age was 55 years old. The results of dysplasia grade re-evaluation showed 72,55% non-dysplasia BE case, 3,9% was BE indefinite; 23,53% was BE with low grade dysplasia; and 1,97% was BE with hard grade dysplasia. There were 15 cases (21,12%) that were changed in diagnosis, from BE to non-BE cases. Conclusion : The diagnosis of BE could be made if there are compatibility between endoscopy examination and hystopathological examination, in which BE presentations was found, either in category 1, 2 or 3based on British Society of Gastroenterology Guidelines 2005 and endoscopy indicated supicion of BE. Changes in diagnosis of BE cases into non-BE cases could happen not because there are incompatibilities of the results of these examinations. This might happen due to nescience regarding the importance of the results of endoscopy examination and its compatibility with the results of hystopathological examination.
Risk factors sharp injury among healthcare workers in Sleman State Hospital Yogyakarta province Indonesia Sani Rachman Soleman; Taufiq Nugroho
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art8

Abstract

Background : The sharp injury is the most burden problem among healthcare workers. The prevalence slightly increased as consequences spreading blood-borne pathogen. Some researchers had found several variables associated sharp injury among medical workers in the hospital. Objective : The objective of this research was to identify variables that significantly correlated sharp injury among healthcare workers in Sleman State Hospital, Yogyakarta Province, Indonesia. Methods : A cross-sectional study was conducted with total sampling as the method to collect respondents. Total population including a doctor, nurse, midwife, laboratory assistant has been selected based on inclusion criteria such as length of work more than one year and approved to be respondents, amounted 133 samples research. The analysis used chisquare for bivariate and logistic regression test for multivariate. Results : There were nine variables had identified that were age, gender, the level of education, the length of work, salary, occupation, employment status, body mass index, and the marital status. According chi-square analysis obtained gender, the level of education, salary, occupation, employment status and body mass index which were significantly correlated sharp injury (p-value > 0.05). Therefore, only two variables based on logistic regression had statistically related sharp injury. Those variables were salary <1.388.000 IDR (p-value 0.008, aOR 0.135, CI 0.031- 10.594) and abnormal body mass index (p-value 0.000, aOR 6.218, CI 2.552-15.147). Conclusion : In summary, there were two variables had correlated sharp injury among healthcare workers in Sleman state hospital Yogyakarta province, Indonesia; salary and body mass index.
Effects of co-chemotherapy ethyl acetate fraction of eurycoma longifolia jack roots and doxorubicin against apoptosis through expression p53 mutant and Bcl-2 Galih Dwi Mulyati; Laela Hayu Nurani; Sitarina Widyarini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 1, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss1.art9

Abstract

Background : It was found mutations of p53 gene in Breast cancer. Mutant p53 protein caused a decrease in cell apoptosis mechanisms through increased expression of Bcl-2. Breast cancer therapy is commonly used chemotherapy using Doxorubicin. However, effectiveness of the use of this chemotherapeutic agent is limited due to the emergence of side effects and toxic to normal cells. Therefore, it is necessary to develop new drugs for combination of chemotherapy. Eurycoma longifolia Jack roots has the potential as co-chemotherapy of breast cancer and it is not toxic to normal cells. Method : Rats were divided into 5 groups. Each group consisted of four female white Sprague Dawley rats. Group 1 (Normal), group 2 (DMBA 20 mg/kgB.W), group 3 (DMBA +Doxorubicin 1.12 mg/kgB.W), group 4 (DMBA +fractions 100 mg/kgB.W), group 5 (DMBA+Doxorubicin +fractions). All the rats were sacrificed at weeks 16 and to be taken their breast tissue. Immunohistochemistry was performed using a mouse monoclonal antibody mutant (BioGenex) and Bcl-2 (BIOSS). Results : expression of mutant p53 percentage obtained for group I (9.35 ± 0.32)%, II (21.65 ± 1.60)%, III (10.72 ± 2.52)%, IV (11.63 ± 3.39)%, V (12.72 ± 3.44)%, While the percentage of Bcl-2 expression obtained for I (20.62 ± 10.09)%, II (52.83 ± 3.61)%, III (24.38 ± 3.54)%, IV (38.01 ± 6.25)%, V (27.99 ± 4.27)%. The data was statistically tested by Kruskal Wallis test (p< 0.005). Conclussion : Co-chemotherapy of E. longifolia Jack roots and Doxorubicin can stimulate apoptosis through decreased in the expression of mutant p53 protein and Bcl-2 in breast tissue of rats induced by DMBA.

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