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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
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Search results for , issue "Vol 7 No 1 (2021)" : 12 Documents clear
RATIONAL DRUG USE (RDU) BASED ON PATIENT CARE INDICATOR IN PRIMARY HEALTH CENTER IN SEMARANG Nisa Febrinasari; Arifin Santoso; Abdur Rosyid; Aditya Dwi Meilani
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3021

Abstract

Rational Drug Use has several indicators, one of which is service indicators, where service indicators will play a role in increasing rational drug use so that it can support the success of treatment to achieve a better quality of life and patient welfare. The purpose of this study was to determine rational drug use in the city of Semarang based on service indicator parameters. This research is a descriptive-analytic with a cross-sectional design, data collection is done prospectively with a direct observation approach and direct interviews with respondents. The number of respondents was 744 patients (372 at Puskesmas N and 372 at Puskesmas TK who were taken by consecutive sampling. The data were processed using the Mann-Whitney statistical test with a p-value <0.05. The results of this study indicate that the use of drugs in Puskesmas N and Puskesmas TK There is a significant difference with a p-value <0.05. In the meantime of medical consultation 5-11 minutes; the average time for drug preparation 10-16 minutes; the percentage of drug delivery suitability is 100%; the percentage of adequate labeling is 100% and the percentage of knowledge Patients at the puskesmas approach rationality and there are differences in services between the two Puskesmas. The government needs to increase the number of pharmacists and improve infrastructure, especially in terms of drug counseling at each puskesmas so that it is hoped that patient knowledge of the drug regimen to be consumed will increase.
IMPACT OF SINGLE BULB GARLIC (ALLIUM SATIVUM VAR. SOLO) ON THE NUMBER OF LEYDIG AND SERTOLI CELLS IN RATS Ika Buana Januarti; Fadzil Latifah; Nur Fidia Fatmawati
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3056

Abstract

Single garlic bulb has been studied as aphrodisiac, this is related to the presence of secondary metabolites flavonoids, alkaloids, and saponins. The metabolite content of single garlic tuber ethanolic extract (EEUBPT) will be investigated for its effect on the histopathological picture and the number of Leydig cells and testicular Sertoli cells in rats. Sample research consist of 25 Wistar rats aged 3-4 months divided into 5 groups. Group I was negative control given 0.5% Na-CMC; group II (positive control) was given Jamu Pasak bumi. Groups III, IV, and V were each given EEUBPT at doses of 450 mg/kgBB, 900 mg/kgBB, dan 1350 mg/kgBB of body weight. Each group was given treatment for 14 days, then the testes were taken on the 14th day. The results were analyzed using the One Way Anova parametric test (p <0.05) and post hoc. The ethanolic extract of a single garlic bulb affected the number of Leydig cells at a dose of 1350 mg of body weight but did not significantly influence the number of Sertoli cells.
THE INFLUENCE OF SOCIODEMOGRAPHIC FACTORS ON KNOWLEDGE AND ATTITUDES ABOUT THE USE OF ANTIBIOTICS IN RURAL COMMUNITIES: OBSERVATIONAL STUDY IN CEMPAKA BANJARBARU DISTRICT Rahmayanti Fitriah; Nurul Mardiati
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3181

Abstract

Antibiotics are examples of drugs that are often used incorrectly. Such misuse is often influenced by the lack of knowledge and attitudes towards the use of antibiotics, so in this study we want to know what sociodemographic factors have an influence on knowledge and attitude on antibiotic use in rural communities at Cempaka Banjarbaru District, South Kalimantan, Indonesia. This type of research is descriptive analytic with a sampling technique that is proportional stratified random sampling using a questionnaire. There are 380 respondents taken as a sample. Analysis data used is univariate and bivariate with chi-square test. The result of public knowledge research on the use of antibiotics included in the good category that is 58.2 % and attitudes included in the positive category that is 98.4 %. Statistical test results show that there is a significant influence between sociodemographic factors of recent education and income on the level of knowledge, while sociodemographic factors of age, sex and occupation on the level of knowledge have no significant effect. On the results of statistical tests sociodemographic factors (age, sex, occupation, last education and income) on attitudes do not have a significant effect.
QUANTITATIV ANALYSIS AND PHARMACOECONOMICS OF ANTIBIOTIC USE IN COMMUNITY-ACQUIRED PNEUMONIA (CAP) IN PKU MUHAMMADIYAH GAMPING Ayunda Putri Hadiningrat; Akrom -; Risdiana Irma
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3251

Abstract

Antibiotics are therapies used in cases of infection. Inappropriate use of antibiotics will cause the impact of resistance. Antibiotic use studies need to be done as a step to reduce this impact. The purpose of this study was to determine the practice of using antibiotics by measuring the quantity using the Defined Daily Dose (DDD) and DU90% method in inpatients with a diagnosis of Community-Acquired Pneumonia (CAP) at PKU Muhammadiyah Gamping Hospital. This study is a retrospective study on inpatients of PKU Muhammadiyah Gamping Hospital in 2016-2018. Data was obtained from patient medical records. The results showed a change in the pattern of antibiotic used in 2016-2018. Ceftriaxone and ceftazidime are the most widely used antibiotics. Ceftriaxone with a DDD value of 12.59; 22.49; 23.53 / 100 bed-days and ceftazidime with a DDD value of 17.09; 12.98; 10.59 / 100 bed-days. Antibiotics that are included in DU 90% are Ceftriaxone, Ceftazidime, Cefixime and Levofloxacine. The conclusion of this study is that there is a change in the pattern of antibiotic use in cases of Community-Acquired Pneumonia (CAP) in 2016-2018.
TEST THE POTENTIAL OF PINEAPPLE (Ananas comosus L.) JUICE TO REDUCE CONTENT OF COPPER (Cu) METAL BY ATOMIC ABSORPTION SPECTROPHOTOMETRY (AAS) Dinna Fitria; Devina Inggrid Anggraini
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3511

Abstract

Accumulation of copper (Cu) metal in the body causes tissue damage. Metals that can’t be excreted into the blood or bile by the liver can cause cirrhosis, so the body needs antidotes to reduce metal content. Pineapple (Ananas comosus L.) contains 78% citric acid of total acid. Citric acid was able to form complex compounds with metal. The aims of this research were to know the ability of pineapple juice (Ananas comosus L.) to reduce content of copper (Cu) metal and the concentration of pineapple (Ananas comosus L.) juice that can reduce the highest content of copper (Cu) metal. Pineapple juice was made in five series of concentration (20%, 40%, 60%, 80%, and 100%). Copper metal of 20 ppm was given the addition treatment of each concentration series of pineapple juice. The solution of each concentration was separated using chloroform. The water phase which was the residual copper (Cu) metal that does not react with citric acid, was analyzed using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 324.7 nm. The results of this research were showed that the concentration of pineapple juice 80% can reduce the content of copper (Cu) metal of 24.6896 %.
OPTIMIZATION ANTIBACTERIAL PRODUCTION TIME OF ACTINOMYCETES ISOLATES (TE 235 ISOLATES) AGAINS ANTIBACTERIAL ACTIVITY ON ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS Sutiara Prihatining Tyas; Alfian Syarifuddin; Ni Made Ayu Nila Septianingrum
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.3547

Abstract

The search for new Antibiotics is needed in the hospital because of the multi-resistance Antibiotics that result in an increase in deaths due to Antibiotic abuse in dealing with infectious diseases, so it is necessary to explore to get potential new antibiotics. Actinomycetes are microorganisms that can produce is antibiotics. Actinomycetes isolate (isolate TE 235) has been isolated from rizosphere soil of sugarcane root crops. This study aimed to determine the optimal time of TE 235 isolates in producing secondary metabolites in the form of antibiotics that can test bacteria Escherichia coli and Staphylococcus aureus and the growth profile of TE 235 isolates were reviewed based on the production of cell biomass. The activity test method used in this study is a suitable test method. The results showed that the liquid culture of Actinomycetes isolates (isolate TE 235) had an optimal time to produce secondary metabolites (Antibiotics) against Staphylococcus aureus bacteria after incubation for ten days with inhibition zone diameter of 6.67 ± 0.94 mm, whereas against Escherichia coli bacteria on the seventh day with a diameter of inhibitory zone of 10.00 ± 0.82 mm. The results of research on the growth of Actinomycetes bacteria isolate TE 235 based on the weight of cell biomass that underwent the stationary phase on the 9th day. The incubation time of the culture of Isolate TE 235 to obtain optimal approval of antibiotics after ten days of incubation in terms of antibiotic activity on Staphylococcus aureus and Escherichia coli and the growth phase of TE235 isolates as the stationary phase.
ANALGESIC ACTIVITY OF TRANSDERMAL PATCH ETHANOL EXTRACT PIPER NIGRUM L FRUCTUS WITH SOME ENHANCERS ON MICE Lucia Hendriati; Iwan Sahrial Hamid; Teguh Widodo; Regiskha Hermandanie Surya; Alif Ekacahya Wahyudi; Dwi Damayanti Rasdianto
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4033

Abstract

Piper nigrum L fructus with active compound piperin had been known have an analgesic effect. Ethanol extract of Piper nigrum formulated to transdermal patch to reduce side effect of analgesic oral. The aim of this research was to know the effect of sodium lauryl sulphate, Tween 80, isopropyl myristate as enhancer of transdermal patch ethanolic extract of Piper nigrum L. Analgesic effect of Piper nigrum L. carried out by writhing method after acetic acid induction in mice. Parameters used were the number of writhing and macrophage from peritoneal fluid of mice at the end of this study. Based on this study, ethanol extract of Piper nigrum had an analgesic effect. The used of sodium lauryl sulphate 5%, Tween 80 5%, isopropyl myristate6% as enhancer increased the analgesic effect of Piper nigrum L.
THE CORRELATION BETWEEN ACID FAST BACILLI OF THE INTENSIVE AND CONTINUATION PHASE IN PULMONARY TUBERCULOSIS PATIENTS’ CATEGORY 1 Oki Nugraha Putra; Widyananda Kartikasari; Hardiyono _; Ana Khusnul Faizah
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4039

Abstract

Tuberculosis (TB) is a communicable disease caused by M. tuberculosis and known as Acid Fast Bacilli (AFB). The purpose of this study was to analyze the correlation between AFB at the end of the intensive phase and continuation phase and to analyze the variables that associated with sputum conversion at the end of continuation phase in pulmonary TB patient’s category I in several primary public health in Surabaya. This was an observational analytic with a retrospective cohort design. Data were collected by medical records of TB patients from January 2017 to December 2019. One hundred twenty-four of TB patients met the inclusion criteria with 69 male and 55 females, and mean of age was 44.09 ± 12.05 years old. The initial AFB was mostly 1+ (41%). There was a significant correlation between AFB at the end of intensive phase and continuation phase (p-value=0.000; r=0.657) by Kendal-Tau test. Age was significantly associated with sputum conversion at the end of continuation phase (p-value=0.022). The conclusion of this study that there was a significant correlation between AFB at the end of intensive phase and continuation phase
ALPHA-GLUCOSIDASE INHIBITORY ACTIVITIES OF KEDABU FRUIT (Sonneratia ovata BACKER) ETHANOL EXTRACT AND FRACTION Rahma Dona; Haiyul Fadhl; Mustika Furi; Tyasakti Viryana
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4165

Abstract

One of the antidiabetic activity tests is carried out through inhibition testing of the ɑ-glucosidase enzyme. Sonneratia ovata Backer is a mangrove plant that has been used traditionally in medicine. The antidiabetic activity of the fruit samples of Kedabu (Sonneratia ovata Backer) was tested by measuring the inhibition of the ɑ-glucosidase enzyme in vitro. The test sample used ethanol extract (EE) and 3 fruit fractions of Kedabu. The calculation result of the IC50 value obtained at EE was 1.86 µg / mL, the calculation result of the IC50 value obtained in the n-hexane (FH) fraction of Kedabu fruit was 193.32 µg / mL, the calculation result of the IC50 value obtained in the ethyl acetate fraction (FE) of fruit Kedabu is 2.32 µg / mL and finally the calculation result of the IC50 value of water fraction (FA) is 2.29 µg / mL. The positive control in this study, Akarbose, obtained an IC50 result of 0.75 µg / mL. Based on the results obtained, the ethanol extract of Kedabu (Sonneratia ovata Backer) fruit is very active and has the potential as an inhibitor of the ɑ-glucosidase enzyme, followed by the water fraction and ethyl acetate fraction, while the potentially inactive sample is in the n-hexane fraction.
POTENTIAL OF MATOA FRUIT EXTRACT (POMETIA PINNATA) AS ANTIOXIDANT SOURCE Widya Rahmah; Hasyrul Hamzah; Siti Hajar; Sylvan Septian Ressandy; Erlisa Maharani Putri
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4240

Abstract

Pometia pinnata or commonly known as matoa is a typical plant of Eastern Indonesia or Papua that grows throughout the Papua archipelago. Matoa contains alkaloids, saponins, tannins, flavonoids, phenolic compounds, terpenoids, and vitamins A, C, E which can boost the immune system. The study aims to examine whether the matoa (Pometia pinnata) has acted as a source of antioxidants where one of the functions of the antioxidants themselves is to increase the body's immune system by fighting free radicals. This study uses a narrative review approach, which is a secondary research method that does not have specific guidelines in its preparation (non-systematic review) using data collected assembled with research topics from various electronic and non-electronic libraries. Based on the results of the study using comparisons with other foods such as lime, spirulina, and carrots, it turns out that the fruit and fruit skins of Matoa contain more vitamin C. It is known that the skin of the fruit and matoa fruit contains vitamin C which works as an antioxidant to increase the body's immune system by fighting free radicals. Also, based on several studies, it is known that the extract of the stem and matoa bark obtained an IC50 value of more than 70 ppm where this value is classified as strong antioxidant activity.

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